アレルギー
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
16 巻, 6 号
選択された号の論文の14件中1~14を表示しています
  • 原稿種別: 表紙
    1967 年 16 巻 6 号 p. Cover16-
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 表紙
    1967 年 16 巻 6 号 p. Cover17-
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 付録等
    1967 年 16 巻 6 号 p. App14-
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 吉田 康三
    原稿種別: 本文
    1967 年 16 巻 6 号 p. 385-395,445
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
    The duration of parabiotic union is under the control of genetic relationship between each partner. For example, after parabiosing parental mice with F_1 hybrid mice (Their H2-loci are one-sidedly different), F_1 usually develop to have parabiotic disease and separation of parabiotic union occurs. According to studies of passive transfer of immunity and those of complement, we could recognize mutual exchange of humoral factors between parent and F_1. However, it was clearly shown that recolonization of cells only occurs from parental animals to F_1. And cellular chimera from F_1 to parental animals can not be established. When skin grafts from F_1 were transplanted to parental animals while they were joined in parabiosis, parent rejected those grafts in early stage by the second set phenomenon. From these results, it may be considrable that recolonization of cells from F_1 to parental animals are interrupted. This may be caused by immunological reactions of parental animals against tissue antigen of F_1. Histopathological examinations on dead F_1 showed that "parabiotic disease" might be results of immunological reactions (graft-versus host-reactions) of parental cells transferred into F_1. From these observations, we can deny the old concept that parabiotic union at least brings partial tolerant condition.
  • 松原 寛
    原稿種別: 本文
    1967 年 16 巻 6 号 p. 396-413,445-44
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
    It was already reported by our collaborators that the antihemolytic titers (ACL-θ) of the sera against the hemolysin (θ-toxin) of Clostridium perfingens (one of the normal bacterial flora) were shown to be markedly high in some patients with hepatic or renal diseases, and some definite changes could be induced in experimental animals by the sensitization of animals with Clostridium perfringens. Present author further studied on the significance of Clostridium in various diseases from the standpoint of allergy, through the researches including the isolation and identification of Clostridium from the feces of patients, and the measurement of ACL-θ of their sera. 1) The incidence of the positive cultures of Clostridium was 30%, and it was higher in the elder patients. Clostridium perfringens was found most frequently, followed by Clost. histolyticum or lentoputrescens. Positive cultures were obtained more frequently in the patients with liver or kidney diseases, especially in those with congestive liver disease, cholecystopathy, collagen diseases, chronic hepatitis, etc. 2) ACL-θ titers were found to be definitely higher in the group of the patients with hepatic or renal diseases compared to the control group. Particularly in those diseases, such as cholecystopathy, collagendiseases, acute hepatitis, congestive liver diseases, chronic hepatitis, chronic nephritis, etc. the patients with high titers of ACL-θ were found frequently. 3) Serum cholesterol or bilirubin had some influences on the titers of ACL-θ, but no definite correlation could be shown between them. 4) Titers of ACL-θ showed the tendency to decline in accordance with the improvement of the disease. 5) Between clostolysin-θ, streptolysin-O, ACL-θ, and ASLO, there may be some cross-reactivities.
  • 中村 晋
    原稿種別: 本文
    1967 年 16 巻 6 号 p. 414-425,446-44
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
    In 213 cases of bronchial asthma treated and observed in our Allergy Centre during the period from July 15, 1964 to January 14, 1967, the results of clinical studies are as follows:- 1) As to the sexual distinction, male/female ratio of the adult patients (127 cases) with bronchial asthma is 1.59, and that of the pediatric (86 cases) is 2.58. 2) 70.9% of the adult patients and 53.5% of the pediatric have the hereditary diathesis of allergic diseases. 3) According to the complaint of the patients, we investigated what is thought as inductive to asthmatic attacks. It is considered that house dust, smoke, insecticides, paints, woods, etc. have inductive relation to asthmatic attacks; and likewise do egg, milk, chocolate, chicken; yam, taro, spinach, sweet glutinous 'sake', bambooshoot, egg-apple, buckwheat; curry, mustard, etc. The attack frequency of asthma is heightened in October, September, November, March, April, for the year; and from midnight to dawn for the day. Weather before rain, menstruation, overworking, overeating, want of sleep, exitement, irritation, strain, physical exercise or laugh also proved to have some relation to induce asthmatic attacks. 4) The intracutaneous test by inhalatory allergen extracts was tried to examine the sensitivity in each subject. The frequency order of positive reaction was as follows: house dust (62.3%, the highest of all), aspergillus mould, common ragweed pollen, cat's tail pollen (typha angustata), old mat, silk, cottonwool, buckwheat husks, and so on. As to the intracutaneous test by food allergen, positive reaction in children for white of egg and yolk was conspicuous. In 31.5% of all patients, positive reaction to intracutaneous test using these substances coincided with more than one cause stated by subjects. And in 22.0%, positive reaction was proved to some of these substances although subjects did not state any causes of astmatic attacks. Especially in the test by house dust allergen, positive reaction was approved in 69.3% who affirmed the relation to these substances, and as well in 57.1% who denied the relation. 5) From the results of routine clinical examinations, following points are noticed:- a) On summarizing the results of various kinds of examintion, the diagnosis of hepatitis was given in 6 cases with bronchial asthma, and the disorder of hepatic function did not run parallel to the seriousness of asthma. b) In 21 of 60 cases examined by means of electrocardiography, some abnormal curves were noticed. c) Some increasing tendency of WBC was observed in cases of asthmatic attacks, and considered to be related with the infection. Eosinophilia was also noticed in 78.8% of 193 cases during the whole period of observation, and ti seemed to become remarkable simultaneously with astmatic attacks. d) The hypofunction of adrenal cortex was seen in 2 of 12 cases with bronchial asthma, but the number of cases examined was too small to prove the definite tendencies of adrenal function. e) Serum total protain, A/G ratio and protein fraction were normal in large majority of the subjects with bronchial asthma. Only in one case, remarkable hypo-γ-globulin fraction was noticed, and it seems that the interpretation of such abnormality would be a task to be done in the future.
  • 斗ヶ沢 弥
    原稿種別: 本文
    1967 年 16 巻 6 号 p. 426-438,447
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
    For the purpose of investigating the antigenicity of ACTH, the skin test, Prausnitz-Kustner reaction, the leukocytolysis in vitro and the sensitized hemagglutination test with ACTH were performed in the healthy persons without ACTH administration and the patients with or without ACTH administration in their past. The leukocytolysis in vitro, the sensitized heamgglutination test and Schultz-Dale reaction with ACTH were performed in the guinea pigs sensitized with ACTH. The results obtained were as follows: 1) In the skin test, the rate of positive reaction defined with more than 20 mm in the diameter of erythema appeared 20 minutes after intradermal injection of 0.02 ml of ACTH Solution containing 0.1 unit per milliliter was 51.6% in the patients administered ACTH in their past, while positive reaction was not found in healthy persons and the patients in both of. the case given no ACTH Among the patients administered ACTH in their past, the rate of positive reaction in the skin test with ACTH solution was 44.4% in those without the experience of allergic phenomenon related to ACTH, while all those, who had had an allergic reaction against ACTH, showed positive reaction in this test. 2) In the patients administered ACTH in their past, a significant correlation was observed between the reactions in ACTH skin test and histamine skin test. 3) Prausnitz-Kustner reaction and the leukocytolysis in vitro revealed negative in healthy persons and positive in 66.6% and 37.5% respectively of the patients administered ACTH in their past. No definite relationship was found between Prausnitz-Kustner reaction and the leukocytolysis in vitro in the patient with or without allergic reaction against ACTH. No difinite positive reaction in healthy persons was shown in the sensitized hemagglutination test, but it was apparently positive in the patients who had had an allergic reaction against ATCH. 4) In the guinea pigs sensitized with ACTH, the leukocytolysis in vitro showed a positive reaction in all cases with 49.7% of mean decreasing rate, and the sensitizedh emagglutination test as well as Schultz-Dale reaction gave a clear-cut positive reaction. From the results mentioned above, it was considered that ACTH had an antigenicity and hypersensitivity to ATCH was caused by the antigen-antibody reaction due to ACTH.
  • 真下 啓明, 堀内 淑彦, 光井 庄太郎, 佐々木 高之輔, 中村 隆, 小野 康夫, 七条 小次郎, 小林 節雄, 笛木 隆三, 松村 龍 ...
    原稿種別: 本文
    1967 年 16 巻 6 号 p. 439-443
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 赤坂 喜三郎, 小野 康夫, 無江 秀次
    原稿種別: 本文
    1967 年 16 巻 6 号 p. 444-
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 松村 龍雄
    原稿種別: 本文
    1967 年 16 巻 6 号 p. 444-
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 文献目録等
    1967 年 16 巻 6 号 p. 445-447
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 付録等
    1967 年 16 巻 6 号 p. App15-
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 文献目録等
    1967 年 16 巻 6 号 p. Misc2-
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 付録等
    1967 年 16 巻 6 号 p. 1-
    発行日: 1967/06/30
    公開日: 2017/02/10
    ジャーナル フリー
feedback
Top