It was already ascertained through our former reports that the sea-squirt asthma is a typical inhalative one caused by the components of the squirt. And now it is to be reported that the following results concerning the refined antigen extracts of the squirt were obtained through clinical comparisons and examinations. The antigen extracts used here are, firstly the crude antigen extracts got through the D-P method, and secondly the refined antigen extracts got through the Yamamura-method, through precipitation and fractionation by using ethanol, or through the Hollister-Stier-method. 1) In the case of the intradermal test about the patients of the sea-squirt asthma, extraordinarily high percentage of positivity was observed concerning each kind of the above mentioned exrtacts. 2) In the case of the conjunctival test, the antigen extracts got through the D-P method showed high percentage of positivity; whereas, those got through the Yamamura-method or the ethanol method showed very low percentage of positivity. 3) In the case of the P-K test, the percentage of positivity was almost the same in each kind of the antigen extracts. Thus it may be concluded that the protein component of squirts is and important factor as an antigen, and that the low molecular weight of dialysable protein substances has also an effective power as an antigen.
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