巻号一覧
17 巻, 7 号
選択された号の論文の10件中1～10を表示しています
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原稿種別: 表紙
1968 年 17 巻 7 号 p. Cover15-
発行日: 1968/07/31
公開日: 2017/02/10
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原稿種別: 付録等
1968 年 17 巻 7 号 p. App16-
発行日: 1968/07/31
公開日: 2017/02/10
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伊藤 幸治, 青木 良雄, 進藤 宙二, 大城 晶子原稿種別: 本文
1968 年 17 巻 7 号 p. 551-557,619
発行日: 1968/07/31
公開日: 2017/02/10
ジャーナル フリー1) Anti house dust sera were prepared by injecting the concentrated extract of house dust into three rabbits. Two sera out of three formed three precipitin bands against the same extract in double diffusion test. Another serum formed four bands against the extract, but produced only two bands against another lot of house dust. These two bands fused with two of four bands formed by the house dust used immunization. 2) The main component of the house dust extract migrated more slowly than human serum albumin or egg albumin through Sephadex G 200 column. 3) When the mixture of house dust extract and ^<131>I labeled house dust was filtrated through Sephdex G 200 column, the peak of redioactivity appeared before the peak of optical density at 280 mμ. 4) By redioimmunoelectrophoresis, it was shown that ^<131>I labeled house dust reacted with IgG of rabbit. However, there were nonspecfic reaction of ^<131>I labeled house dust with albumin and α-globulin of both immunized and normal rabbit sera. The use of anti rabbit Fab instead of anti rabbit serum succeeded in clearly demonstrating only specific reaction of ^<131>I labeled house dust with immunoglobulins. 5) Invisible complex of ^<131>I labeled house dust and anti house dust antibody was also detected by radioautography.抄録全体を表示PDF形式でダウンロード (1359K) -
木村 郁郎, 守谷 欣明, 西崎 良知, 谷崎 勝朗原稿種別: 本文
1968 年 17 巻 7 号 p. 558-561,619-62
発行日: 1968/07/31
公開日: 2017/02/10
ジャーナル フリーChanges of basophil leucocyte counts of the peripheral blood in bronchial asthma were investigated mainly by our improved method of Kovacs. The results are as follows. 1) The basophils in bronchial asthma generally show a higher count than in healthy controls. 2) During the interval of repeated asthmatic attacks the basophil count is higher than in the asymptomatic period. 3) Particularly in an episode of asthmatic attack, the basopils increase immediately before the attack and decrease to the normal level or lower after the attack has begun. 4) During asthmatic attacks it may be possible to expect a next attack, if the basophil count again tends to increase from the previous low count. 5) This counting method of basophils is easy enough for the routine examination like caluculation of peripheral leucocytes. 6) Observation of the changes of peripheral basophils appers to be a useful laboratory aid for the diagnosis and therapeutic evaluation of bronchial asthma, making possible an early detection of the future attack.抄録全体を表示PDF形式でダウンロード (598K) -
宮本 昭正, 可部 順三郎, 松村 行雄, 斎藤 恒子原稿種別: 本文
1968 年 17 巻 7 号 p. 562-570,620
発行日: 1968/07/31
公開日: 2017/02/10
ジャーナル フリー2. From the investigation with beta-adrenergic blocking agent. Some believed that the constitutional abnormality common to all atopics, especially asthmatics, is inherited of acquired partial blockade (reduced functioning or availability) of the beta-adrenergic receptor. Others stated, however, that partial blockade of the beta-adrenergic receptors is not as important in asthmatics as believed. To assess their points, 17 asthmatic patients, 10 normal subjects and 11 asymptomatic subjects with skin sensitizing antibody were studied. After intravenous injection of propranolol, 6 out of 17 asthmatic patients developed asthmatic attack, and other 4 showed more than 10% reduction of FEV_1, but no significant changes of FEV_1 was noted in normal and asymptomatic subjects. Bronchial sensitivity to aerosolized aceptylcholine increased after injection of propranolol in normal and asymptomatic subjects but their sensitivity did not reach to the range of asthmatic patients. Inhalation provocation test was carried out in 11 asymtomatic subjects before and after propranolol injection but none showed positive even with the presence of skin sensitizing antibody. On the other hand, provocation test became positive in some cases of bronchial asthma after intravenous injection of propranolol. Consequently it is our feeling that the blockade of the beta-adrenegic receptor is not essential but makes subjects predisposed to asthmatic condition. Pliability of respiratory tract might be more important in asthma, however.抄録全体を表示PDF形式でダウンロード (1368K) -
石崎 達, 梶野 宗幹原稿種別: 本文
1968 年 17 巻 7 号 p. 571-574,620
発行日: 1968/07/31
公開日: 2017/02/10
ジャーナル フリーDilution threshold of skin reaction to the solutions of histamine and compound 48/80 were determined on the patients of chronic urticaria, asthma as well as normal subjects. The results show that the patients of chronic urticaria are markedly hypersensitive to histamine and compound 48/80 injected into the skin, meanwhile asthmatic patients reacted mostly as same as normal subjects. The cause of hypersensitivity in the patients of chronic urticaria is considered not to be due to the increase of histamine release from the skin tissue. Through the testing by Yatabe-Gilford questionaire, chronic urticaria due to psycho-somatic factor showed a different pattern from the usual type;the former showed a psychological disturbance, but the latter appeared almost normal. In addition, patients of psycho-somatic type showed nearly normal sensitivity to histamine.抄録全体を表示PDF形式でダウンロード (641K) -
野村 修三原稿種別: 本文
1968 年 17 巻 7 号 p. 575-596,621
発行日: 1968/07/31
公開日: 2017/02/10
ジャーナル フリーIn this present report, were investigated the histological changes in the brain caused by active immunization of autobrain extracts. On the experimental method, immunization in rabbits were performed with own brain suspension which were previously removed surgically, Each animals were received eight intraperitoneal injections, a three days apart, of the 5 ml. of the emulsions and were sacrificed and the histological changes of the brain were observed. The major patho-histological changes were found as follows. 1) in operative lesions, the formation of massive softening and liqefaction changes containing numerous fat granular cells. 2) at the distant brain tissue from operative part, the degeneration, atrophy of nervous cell, neuronophagia, glial proliferation, small softening and demyelinating lesions. On the contrary which left frontal lobectomies were only performed, organization were remarkably investigated and no significant changes were found. These patho-histological changes, predominantly the patenchymal tissue damage in brain were found similar to those in the previous experiment caused the reversed anaphylaxis by rabbit brain extract. (Report 1.) Based on these findings, the above mentioned histological changes with sever necrotic lesions in operative damage may be as result of allergic reaction by the auto-brain tissue, and it is suggested that the pathogenesis of encephalitis and demyelinating disease are caused by autoimmune mechanisms and its mechanisms could be exerted upon delay of organization. In addition to this experiment, was discussed about an autopsy cases of brain abscess that might be thought of similar pathogenesis with this study.抄録全体を表示PDF形式でダウンロード (5278K) -
浅野 誠一, Kikuo Marumo, Yoshiyuki Igaki, Eizo Toyoizumi, Michihito Okubo, ...原稿種別: Article
1968 年 17 巻 7 号 p. 597-609,621
発行日: 1968/07/31
公開日: 2017/02/10
ジャーナル フリーImmunological involvement in the pathogenesis of SLE has been suggested by demonstration of LE phenomenon and/or antinuclear antibodies in the serum, fixations of immunoglobullins and β1C-globulin to glomeruli detected by immunofluorescence technique, and fluctuation of the serum complement. Here, serum C'and C'1, and immunune adherence (IA) were estimated in 21 patients with SLE and 18 normals according to the methods of Mayer and Nelson-Nishioka, respectively. Extremely low levels of C'were observed in acute, untreated and clinically severe patients with pyrexia and/or exanthema, positive LE cell preparation, hypergammaglobulinemia, and renal lesion. Clinical remission induced by steroid therapy accompanied elevation of C'. Fluctuation of IA values in lupus patients parallelled well with that of C', while no conclusion could be drawn as to C'1 from the two estimations made in only one patient.抄録全体を表示PDF形式でダウンロード (1374K) -
佐藤 祐司, 小林 節雄, 七条 小次郎原稿種別: 本文
1968 年 17 巻 7 号 p. 610-618,622
発行日: 1968/07/31
公開日: 2017/02/10
ジャーナル フリーClinical and epideomiological observations of "Mabushi" Bronchial Asthma and Investigations of antigenic substance (s) were performed with the following results: 1. Incidence rate of "Mabushi" Bronchial Asthma is about 2 per 1000 of sericultural population, it corresponds to 14% of total bronchial asthmatic patients in the sericulturist. Among sericulturists, chronic respiratory disease are a little more frequent than among other agricultural populations, and this has been considered to be due to some irritating substance (s) contained in urine of the matured silk worm larvae, the offending allergen of "Mabushi" Bronchial Asthma. 2. Patients with "Mabushi" Bronchial Asthma can clinically be classified into 3 groups according to whether the disease is induced purely by the dust from "Mabushi", or by concurrent sensitization with the dust from "Mabushi" and some other allergen(s), or more strongly by other factors than the allergic one. It is considered therapeutically valuable to treat this disease according to this classification. 3. The irritating substance (s) contained in urine of the matured silk worm larvae is dialyzable against tap water, while the antigenic substance (s) in this urine can be soluted out with ammonium sulfate or detected in the fraction obtained by aceton treatment by Boatner's method. These fraction possessing antigenicity showed positive protein reaction by Lowry's method, therefore the antigenic substance (s) seems to be protein or protein coupling substance (s).抄録全体を表示PDF形式でダウンロード (1252K) -
原稿種別: 文献目録等
1968 年 17 巻 7 号 p. 619-622
発行日: 1968/07/31
公開日: 2017/02/10
ジャーナル フリーPDF形式でダウンロード (293K)
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