VITAMINS

Online ISSN : 2424-080X
Print ISSN : 0006-386X

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Volume 16

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 175-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_175_1

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 175-176
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_175_2

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 176-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_176_1

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 176-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_176_2

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 176-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_176_3

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 177-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_177_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 177-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_177_2

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 177-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_177_3

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 177-178
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_177_4

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 178-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_178_1

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 178-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_178_2

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 178-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_178_3

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 178-179
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_178_4

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 179-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_179_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 179-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_179_2

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

Article type: Article
1959 Volume 16 Pages 179-180
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_179_3

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 180-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_180_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 180-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_180_2

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 180-181
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_180_3

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 181-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_181_1

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 181-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_181_2

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1959 Volume 16 Pages 181-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_181_3

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 182-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_182_1

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 182-183
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_182_2

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 183-184
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_183

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 184-185
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_184

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 185-186
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_185

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METAL AND THIOL REQUIRING VITAMIN B_6 ENZYME

Kozo YAMADA, Syunzi SAWAKI, Chuya YAZAKI

Article type: Article
1959 Volume 16 Pages 187-192
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_187

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 192-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_192_1

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 192-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_192_2

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ON THE DISTRIBUTION OF THIAMINE IN THE ANIMAL BRAIN

Yanao OGURO

Article type: Article
1959 Volume 16 Pages 193-196
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_193

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In the brain of normal cattle and horse, the thiamine content in the grey matter is about twice as much as that in the white matter. The thiamine content in the brain of the normal rabbit varies with its regions. It is low in the cerebrum and spinal cord and high in the brain stem and cerebellum. This variation seems to be due to the differnce in the proportion of the grey and white matters in each part.

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MECHANISM ON THE EFFECT OF INTRASPINAL INJECTION OF THIAMINE IN TREATMENT OF NERVOUS DISEASE

Yanao OGURO

Article type: Article
1959 Volume 16 Pages 196-201
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_196

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Thiamine content in the brain of the rat increases slightly, following intravenous injection of thiamine. Urinary excretion of thiamine injected intraspinally to the patients with nervous disease delays extremely, compared with intravenously injected. Directly after injection of thiamine into the cisterna cerebellomedullaris of the rabbit, thiamine content in brain and cerebrospinal fluid increases markedly, and maintains high level for about 4 hours. It is explained that large dose of thiamine is necessary for treatment of the patients with nervous disease by intramuscular or intravenous injection, but few dose by intraspinal injection, because thiamine penetrates very slowly to the brain from the blood.

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 201-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_201

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PHARMACOLOGICAL STUDIES ON OXYMETHYLPYRIMIDINE : (IV) SITE OF OMP ACTION IN THE BRAIN

Yukihiko ENOMOTO, Chung-taek KIM, Kimiko MOTONISHI, Keizo TAKAHASHI, T ...

Article type: Article
1959 Volume 16 Pages 202-209
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_202

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The site of OMP action in the brain of rabbit is considered to locate in the mesencephalon and diencephalon, especially in the hypothalamus. However, it has been clarified that complete OMP convulsion does not occur without the cortex cerebri. The central nervous system of embryo is not influenced by 5 mg of OMP. The OMP convulsion is antagonized by chloral hydrate but never antagonized by sodium glucuronate, glucuronolactone, β-hydroxy-γ-aminobutyric acid nor 1-amino-2-oxypropane sulfonic acid.

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 209-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_209_1

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 209-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_209_2

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PHARMACOLOGICAL STUDIES ON OXYMETHYLPYRIMIDINE : (V) EFFECT OF CENTRAL NERVOUS SYSTEM DEPRESSANT ON THE CONVULSIONS INDUCED BY OMP, INAH OR THIAMINE

Yukihiko ENOMOTO, Chung-taek KIM, Kazuta NAGASHIMA, Kimiko MOTONISHI, ...

Article type: Article
1959 Volume 16 Pages 210-214
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_210

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The OMP convulsion and the death was completely antagonized by the administration of a proper dose of chloral hydrate and sodium diethylbarbiturate. Ether and urethan controlled the convulsion, but most of the treated mice died. Magnesium sulfate, potassium bromide, nicotinamide and pantothenic acid had little antagonistic effect. γ-Aminobutyric acid in the brain was decreased with OMP, and this decrease was not recovered by chloral hydrate treatment. The INAH and thiamine convulsion was depressed by a proper dose of sodium diethylbarbiturate. Ether and magnesium sulfate controlled INAH convulsion but the animal died. Potassium bromide had no influence on INAH convulsion.

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 214-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_214_1

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 214-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_214_2

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PHARMACOLOGICAL STUDIES ON OXYMETHYLPYRIMIDINE : (IV) ON THE PRINCIPAL CAUSE OF ACUTE TOXIC DEATH BY OMP

Yukihiko ENOMOTO, Masutaro SANO, Kazuta NAGASHIMA, Hiroshi SHIMOYAMA, ...

Article type: Article
1959 Volume 16 Pages 215-225
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_215

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The principal cause of the acute toxic death of animals with OMP was the cardiovascular disturbance due to the repeated convulsions, except in the case of small animal such as mice. The death with INAH convulsion was led by the respiratory paralysis. If an adequate dose of sodium diethylbarbiturate was injected to the rabbit in convulsion before the rabbit fell into shock, the convulsion was mitigated and the animal survived.

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 225-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_225_1

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 225-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_225_2

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STUDIES ON VITAMIN C METABOLISM : (II) THE EFFECT OF THE ADMINISTRATION OF ACID AND BASE ON THE URINARY EXCRETION OF ASCORBIC ACID

Junya TERUUCHI, Hiroko MOCHIZUKI

Article type: Article
1959 Volume 16 Pages 226-234
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_226

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The effect of dosed various acids on the urinary excretion of L-ascorbic acid was investigated. The effect was found to be related to the blood content of ascorbic acid. When the blood level of ascorbic acid was 0.6-0.8 mg%, the effect of acids on the excretion was so little as the control. But when the same doses of acids were administered to subjects saturated with ascorbic acid, the urinary excretion of ascorbic acid, increased markedly. Organic acids, such as citric and acetic acid, produced a marked increase in the excretion of ascorbic acid, but HCl and NaHCO_3 had only a slight influence. In addition, the effect of the same acids on the urinary excretion of various acids was measured, and it was noted that these results were different from the result of ascorbic acid. This observation is of considerable interest since it suggests the possibility of the difference of mechanism between the effect of acids on ascorbic acid excretion and the acid base balance in the body.

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ASCORBIC ACID CONTENT IN FISHES

Choten INAGAKI, Hiroyasu FUKUBA, Akemi KANOH

Article type: Article
1959 Volume 16 Pages 234-236
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_234

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The ascorbic acid contents in fishes were reexamined. For this purpose, the 2,4-dinitrophenylhydrazine method was found to be the excellent one. It was ascertained that the content of this vitamin in fishes is small varying from 0.3 to 2.0 mg%

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 236-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_236_1

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 236-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_236_2

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STUDIES ON THE NUTRITIVE EFFICIENCIES OF THIAMINE DERIVATIVES : (V) ABSORPTION AND EXCRETION OF THIAMINE DICETYLSULFATE IN RATS

Yasuto WATANABE

Article type: Article
1959 Volume 16 Pages 237-239
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_237

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Increasing amounts of thiamine dicetylsulfate or thiamine hydrochloride were given orally to rats and the absorption and excretion of these thiamine derivatives were studied. No significant difference was found between the two derivatives. Both of these derivatives were found to be absorbed almost completely up to 20γ per 100g body weight per day, and not absorbed more than 80γ per 100g body weight.

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SEVERAL BIOLOGICAL ACTIVITIES OF THIAMINE TETRAHYDROFURFURYL DISULFIDE

Yoshitomo ARAMAKI, Tadayuki KOBAYASHI, Koji FURUNO, Ichiro ISHIKAWA, Z ...

Article type: Article
1959 Volume 16 Pages 240-244
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_240

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Thiamine tetrahydrofurfuryl disulfide (TTFD), a new analogue of allithiamine, was studied on its several biological activities comparing with thiamine and thiamine propyl disulfide (TPD). TTFD showd equivalent curative activity as thiamine in the rat growth assay. TTFD, when administered intravenously to rabbits caused a marked elevation of blood thiamine level, especially in the blood cells, and sustained this high level. The results of toxicity tested by intraperitoneal and oral routes, suggested the better gastrointestinal absorption of TTFD than that of thiamine hydrochloride. Local irritability of TTFD was neglisible compared with that of TPD.

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[title in Japanese]

[in Japanese]

Article type: Article
1959 Volume 16 Pages 244-
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_244

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CHRONIC TOXICITY OF THIAMINE TETRAHYDROFURFUYL DISULFIDE

Yoshitomo ARAMAKI, Ichiro ISHIKAWA, Kyo KAZIWARA, Motoi ISHIDATE

Article type: Article
1959 Volume 16 Pages 245-249
Published: 1959
Released on J-STAGE: December 22, 2017

DOIhttps://doi.org/10.20632/vso.16.0_245

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Chronic toxicity of thiamine tetrahydrofurfuryl disulfide (TTFD) in rats for 6 months has been studied. Rats were fed on the basal diet, to which 0,40,200,or 1,000 ppm of TTFD or thiamine hydrochloride was added. Even at the highest level of TTFD or thiamine hydrochloride, the body weight increase, food intake, food efficiency and organ weight of the rats have not been affected. Any anatomical and histological changes have not been checked. It was concluded that the chronic toxicity of TTFD in rats at a dose of over 2,500 times of usual human dosage in relation to body weight had been neglisible.

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