昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
13 巻, 4 号
選択された号の論文の13件中1~13を表示しています
  • B1, Thiamine-Propyl-Disulfide並にThiamine-Allyl-Disulfideに就て
    武藤 壽剛, 本多 進, 森田 俊夫, 藤内 奈良雄, 藤沼 隆, 山口 滋嗣, 山田 篤, 野呂 文彦, 林田 健憲
    1953 年 13 巻 4 号 p. 217-230,285
    発行日: 1953/12/01
    公開日: 2010/09/09
    ジャーナル フリー
    In the present paper, experiments on the general actions and absorption of vitamin. B1, thiamine-propyl-disulfide and thiamine-allyl-disulfide (abridged hereunder as B1, TPD and TAD) are reported.
    When mice were injected intravenously with 3.5 mg of TAD or 3 mg of TPD, they immediately become fatal. However, with 1 mg of TAD or TPD, there were, generally, . no remarkable actions found. No remarkable changes in the temperature of rabbits were recognized with a moderate amount of TAD or with TPD.
    In the Shioya's 3 rd Method, the amplitude of the isolated toad heart was not changed by these drugs at their lower concentrations. They also did not cause any changes. in the number of pulsation, amplitude or in the amount of infusion liquid of the isolated guinea .pig heart at their lower concentrations. Although the application of these drugs inn a small amount or in a moderate amount did not show remarkable changes in the blood pressure or in the respiration of rabbits, a large amount (10mg/kg) of TAD or TPD caused a moderate lowering of blood pressure and stimulation of respiration. They also cause aa transient contraction of the blood vessel in the posterior extremity of toad but this action was observed somewhat stronger in the case of TPD. TAD or TPD did not demonstrate inhibitory actions on the vascular actions of adrenalin. No changes in the intestinal movement of the isolated intestine of rabbit were caused by TAD or by TPD. A slight tendency of erythropenia and leukocytosis in the hemogram when a large amount of TAD or TPD was applied. In the hemogram, a transient decrease in the percentage of lymphocytes and an increase in the percentage of pseudo-eosinophiles with lobulated nucleus were recognized. As to the absorption of B1, TAD and TPD, the absorption of TAD and TPD from the stomach and the large intestine was found evidently more rapid than B1.
  • 小河原 四郎
    1953 年 13 巻 4 号 p. 231-232,286
    発行日: 1953/12/01
    公開日: 2010/11/19
    ジャーナル フリー
    From one length and three breadths of the stem, the formula of the stem was originated, of which the quantitative measurements were:
    1) Stem-length: the vertical distance to the vertex from the tuberosity of the Ischium, namely, sitting height,
    2) Stem-breadth I: maximum head breadth direct distance between the euryon of the right and left sides,
    3) Stem-breadth II: breadth of shoulders direct distance between the acromion of the right and left sides,
    4) Stem-breadth III: maximum hip breadth direct distance between the most projected hips of the right and left sides.
    From these four quantitative measurements, the following six indices were derived:
    I) Stem index I (= steam-breadth I. 100/stem-length),
    II) Stem index II (= stem-breadth II. 100/stem-length),
    III) Stem index III (= stem-breadth III. 100/stem-length),
    IV) Stem-breadth index A (= stem-breadth I. 100/stem-breadth II),
    V) Stem-breadth index B (= stem-breadth III. 100/stem-breadth II),
    VI) Stem-breadth index C (= stem-breadth I. 100/stem-breadth III) .
    These indices were sought from the anthropological ages of many cases of men and women, and centered around their respective arithmetical averages; indices were, classified into five or six types taking standard and other factors into consideration.
    These types were symbolized simply from one to five or six, which in turn were charted in parallel arrangements in the order of indices I II III A B C, producing a form which was named the Formula of the Stem.
  • 小河原 四郎
    1953 年 13 巻 4 号 p. 232-234,286
    発行日: 1953/12/01
    公開日: 2010/09/09
    ジャーナル フリー
    From one length and four widths of the lower limb, the formula of the lower limb was originated, of which the quantitative measurements were:
    1) Length of lower limb: iliospinal height +Symphysion height/2,
    2) Width I of lower limb: Width where the thigh is largest in circumference,
    3) Width II of lower limb: Width where the thigh is smallest in circumference,
    4) Width III of lower limb: Width where the leg is largest in circumference.
    5) Width IV of lower limb: Width where the leg is smallest in circumference. From these five quantitative measurements, the following six indices were derived:
    I) Lower limb index I (= Width I of lower limb. 100/length of lower limb),
    II) Lower limb index I I (= Width II of lower limb. 100/length of lower limb),
    III) Lower limb index III (= Width III of lower limb. 100/length of lower limb),
    IV) Lower limb index IV (=Width IV of lower limb. 100/length of lower limb),
    V) Lower limb width index A (= Width III of lower limb. 100/width I of lower limb),
    VI) Lower limb width index B (= Width IV of lower limb. 100/width II of lower limb) .
    These indices were sought from the anthropological ages of many instances of men and women, and centered around arithmetical averages of indices; six types of classifications were made with considerations for standard variations.
    These types were symbolized simply from one to six which in turn were charted in parallel arrangements in the order of indices I II III IV A B, producing a form which was named the First Formula of the Lower Limb.
  • 小河原 四郎
    1953 年 13 巻 4 号 p. 234-235,287
    発行日: 1953/12/01
    公開日: 2010/09/09
    ジャーナル フリー
    From one length and three circumferences of the trunk, the second formula of the trunk was originated, of which the quantitative measurements were:
    1) Trunk-length : the vertical distance to the suprasternale from the symphysion.
    2) Trunk-circumference I: the circumference of shoulders,
    3) Trunk-circumference II: the horizontal circumference passing the substernale, namely, lower circumference of the chest,
    4) Trunk-circumference III: the pelvic circumference.
    From the above four quantitative measurements, the following six indices; namely,
    I) Trunk length-circumference index I (LUI) : = Trunk-length. 100/trunk-circumference I,
    II) Trunk length-circumference index II (LUII) : = Trunk-length. 100/trunk-circumference II,
    III) Trunk length-circumference index III (LUIII) : Trunk-length. 100/trunk-circumference III,
    IV) Trunk circumference index A (UA) : = Trunk-circumference I. 100/trunk-circumference II,
    V) Trunk circumference index B (UB) : = Trunk-circumference I. 100/trunk-circumference III,
    VI) Trunk circumference index C (UC) : = Trunk-circumference II. 100/trunk-circumference III.
    These indices were sought from the anthropological ages of many cases of men and women, and centered around arithmetical averages of indices; five or six types of classifications were made with considerations for standard variations.
    These types were symbolized simply from one to five or six which in turn were charted in parallel arrangements in order of indices LUI LUII LUIII UA UB UC, producing a form which was named the Second Formula of the Trunk.
  • V.B1, 塩酸塩TPD並びにPASの大腸内吸収に就て
    岩倉 理雄, 本多 進, 森田 俊夫, 黒田 恒治, 松元 英輔, 野呂 文彦
    1953 年 13 巻 4 号 p. 236-242,288
    発行日: 1953/12/01
    公開日: 2010/09/09
    ジャーナル フリー
    Previously, Muto, Honda and others conducted experiments on the absorption of vitamin B1 hydrochloride and TPD in the large intestine, and recognized that the amount of these substances absorbed were quite small when they were administered alone as enema. Further, Sekiya performed experiments on the absorption of PAS in the large intestine, and reported that almost no absorption was recognized when PAS alone was administered as enema.
    In the present paper, the authors investigated as to how the absorption of vitamin B1 hydrochloride, TPD and PAS in the large intestine is affected by those absorption promoting substances, which were hitherto taken up in the authors' Department. The followings are the conclusions briefly summarized.
    1) Simple combination of PAS with vitamin B, hydrochloride or with TPD did not promote the absorption.
    2) The absorption was remarkably promoted in every cases when the combination of PAS with vitamin B1 hydrochloride or with TPD further combined with cattle bile, glycocoll, histidine, calcium chloride or with glucose. Histidine demonstrated specifically favorable absorption.
    3) When administered as enema, either alone or in combination, the amount of. vitamin B1 absorbed in the case of TPD was found larger compared with that in the case of vitamin B1 hydrochloride.
  • 広田 孝之
    1953 年 13 巻 4 号 p. 243-260,289
    発行日: 1953/12/01
    公開日: 2010/11/19
    ジャーナル フリー
    It has been clarified by Tomosaburo Ogata and members of his school that salivary gland is secreting internally as well as externally. The salivary gland hormon was named “parotin.”
    It has already been reported that parotin is very closely related to the development of bone and dental tissues, and that it is related to the calcium metabolism. It is also known by the microscopical and macroscopical investigations on the embryonal stage of animals that parotin in an adequate amount acts promotingly on the general development and the development of feathers of chick embryo, and that the development inhibitory action of calcium chloride on the chick embryo is eliminated by parotin.
    In the present paper, the author attempted to trace from the pharmacological standpoint the correlationships between salivary gland hormon (parotin) and calcium employing fertilized eggs of white leghorn.
    Eggs of white leghorn weighing approximately 50 g were selected. Solutions of, parotin were prepared with physiological saline to contain 0.2 mg, 0.01 mg, 0.1γ and 0.01γ of parotin per 0.1 cc of physiological saline. Eggs of each group received 0.1 cc of the white by usual tech-parotin solutions prepared as above respectively within the egg nique. Each egg of the control group was injected with 0.1 cc of physiological saline in a similar manner, and each egg of another group was left untreated. Eggs of the above S groups were incubated, and 5 eggs were taken out at random from each group after 9 days, ' 12 days' 15 days' and 18 days' incubation as samples. The calcium content of allantoic fluid the calcium content of the whole embryo and the amount of ash residue of each of these eggs thus taken out were estimated. As the results, the followings were obtained.
    The calcium content in the allantoic fluid was found only minute after 9 days and 12 days. Futhermore, the results could not be compared due too large experimental error .in the determination technique.
    After 15 days' incubation, a remarkable differences in the calcium content of the allantoic fluid, were recognized, showing a significant difference by statistical study. In the cases of the group which received a highly concentrated parotin solution (0.2 mg per 0.1 cc), a large amount of calcium was proved to be present, but no difference was recognized from the control group which received physiological saline. In the cases of the group which received parotin solution of low concentration (0.1γ and 0.01γ), the values were found smaller compared with those with solution of high concentration and with the control groups. In other words, the calcium content of the allantoic fluid vlas found decreased when an adequate amount of parotin was applied.
    Due to scarcity in the calcium content in the whole embryo after 9 days' incubation, 5 eggs had to be tested at one time, thus making statistical analysis of the results impossible. However, an arythmetic average indicating decrease in the higher concentration and increase in the lower conceentration was obtained.
    A statistically significant difference in the calcium content of the whole embryo way recognized after 12 days' incubation. The calcium content of the embryo received parotin solution of high concentration was found smaller than that of the physiological saline control group, and the value for the lower concentration group was found larger compared with that for the higher concentration group. But the increment in this case did not show any statistically significant difference with that for the physiological saline control group.
    No statistically significant difference was recognized in the calcium content of the whole embryo after 15 dais' and 18 days' incubation. Considering from the arythmetic average, the low concentration group demonstrated the largest increment.
    The ratio of the amount of ash residue to the calcium content of the whole embryo was investigated
  • 山本 一朗, 鳥井 津平, 谷崎 雄彦
    1953 年 13 巻 4 号 p. 261-264,291
    発行日: 1953/12/01
    公開日: 2010/09/09
    ジャーナル フリー
    The authors report the clinical observations relative to the mediastinal shifts before and after the induction of pneumothorax by serial chest roentgenograms of 190 cases at authors' clinic, which were made during the period between January 1946 and August 1953. Of the entire 190 cases, 136 were unilateral, 26 were bilateral and 28 were with contralateral thoracoplasty. The follow-up observations were conducted for more than 6 months.
    Exacerbations of tuberculosis among the cases of unilateral Group were as follows:
    Reactivates of contralateral lesions (Group A) were 23 out of 76 cases (30.2%), and spreads of contralateral lung (Group B) were 2 out of 58 cases (3.4%) .
    Mediastinal shifts:
    Exacerbations in Group A: The mediastinal shifts to the operated side were 15 out of 18 cases (83.3%) ; normal mediastinums were 2 out of 19 cases (10.5%) ; mediastinal shifts to the contralateral side were 6 out of 39 cases (15.3%) .
    I. Group B: The mediastinal shifts to the operated side were 15 out of 58 cases, in which spreads were 13.3%, and no exacerbation was observed in the Group of the normal mediastinum and the Group of the mediastinal shifts to the contralateral side.
    Duration of pneumothorax:
    Exacerbations occurred in 100 of the cases belonging to the Group of mediastinal shifts to the operated side, which received pneumothorax over 4 years. The Group of normal mediastinum and the Group of mediastinal shifts to the contralateral side often exacerbated comparatively in an early stage. However, no definite relationships of the mediastinar shifts and the duration of pneumothorax to the incidence of spread of the disease were recognized.
    Exacerbation of disease in the bilateral Group were 2 out of 26 cases (7.6%) and with contralateral thoracoplasty were 2 out of 28 cases (7.1%) .
    Exacerbations in contralateral lungs with thoracoplasty were observed in 13% of the cases in authors' clinic. When this percentage is compared with 30.2% observed in Group A, a remarkable difference is noted. It is well recognized that mediastinal shifts may have been the cause of these exacerbations. For that reason, although the mediastinal shifts to the contralateral side of the pneumothorax were 44.7% and to the same side of the pneumothorax were 24.6%, those to the contralateral side of the thoracoplasty were as many cases as in 80.5%
    Incidences of new lesion in the contralateral side were mostly found in the Group of mediastinal shifts to the pneumothorax side, and exacerbations of the disease were found not affected by the mediastinal shifts.
    According to the clinical observations, streptomycin-PAS treatment seems to be effective to prevent the spread of the diseases, though these chemotherapeutic measures were often useless when new spreads were once established.
  • 諸動物脾藏の血液凝固促進並に抑制因子に就て
    河合 常雄
    1953 年 13 巻 4 号 p. 265-281,292
    発行日: 1953/12/01
    公開日: 2010/09/09
    ジャーナル フリー
    Following the investigation by Yoshimatsu on the blood coagulation promoting substance and blood platelet increasing substance contained in the splenic component, the author attempted to conduct experiments on the crystaline substance and extracts isolated from the fraction, which is left untouched, of cattle spleen, and to clarify the presence of the fraction containing strong coagulation promoting substance by a similar method to Yoshimatsu's experiments. Further, the author prepared splenic extract of horse and cattle for his experiments by a different procedures from that hitherto adopted by the author's Department. The author further investigated the behavior of the blood coagulation promoting substance contained in the human spleen (patients suffering from Banti's disease, hemolytic jaundice, laryngeal tuberculosis and esophagus cancer) and compared the results with those from the spleen of animals. The results obtained are as follows.
    1) Among the crystaline substances isolated from the 94 % alcohol insoluble fraction of cattle spleen, Crystal [I-R-1] and Crystal [II-R-1] have blood coagulation promoting activity and blood platelet increasing activity. Further, stronger activity is demonstrated when these two crystals are applied in combination, or when these two crystals combined with 94 % alcohol soluble extract of cattle spleen is applied. Crystal [I-R-M-2] possesses only weak activity.
    2) Among extracts isolated from 94 % alcohol insoluble fraction of cattle spleen, [A] and [B] possess the above two activities, though they are weak, but [C] possesses almost no such activity.
    3) These two activities of extract treated by cadmium sulfate of horse spleen are weak.
    4) Activities of cattle spleen extract treated by acetone are stronger than those of horse spleen extract treated by cadmium sulfate.
    5) The blood coagulation inhibiting factor exists in the spleen of patients suffering from Banti's disease or hemolytic jaundice (acetone insoluble extract of dehematized spleen) .
    6) In the spleen of patients suffering from Banti's disease, anemia inducing factor is also contained.
    7) The blood coagulation inhibiting factor and anemia inducing factor are heat stable, and their activities are not lost even after a long standing.
    8) The blood coagulation inhibiting factor is not generally transfered to the blood.
    9) In the spleen of patients suffering from laryngeal tuberculosis of from esophagus cancer (acetone insoluble extract of dehematized spleen), blood coagulation promoting factor can be proven to the same degree as in the normal spleen of various animals. This substance is transfered to blood to certain extent.
    10) The activity of the blood coagulation promoting factor isolated from human spleen is far less active compared with that of Crystal [I-R-M-1] (C6H13O2N) isolated from 94 % alcohol soluble fraction of cattle spleen by Tsunoo et al.
    11) It is presumed that the blood coagulation promoting factor is not necessarily single, but the activity is demonstrated by the synergistic action of certain number of such active factors.
    In short, the author successfully isolated crystals or fractions possessing blood coagulation promoting activity from spleen of various animals, but their activities are found to be far less active when compared with that possessed by the Crystal [I-R-M-1] isolated by Tsunoo et al previously. Furthermore, the presence of the blood coagulation inhibiting factor in the spleen of patients suffering from Banti's disease or hemolytic jaundice was confirmed.
  • 山口 滋嗣, 山田 篤
    1953 年 13 巻 4 号 p. 282-284,293
    発行日: 1953/12/01
    公開日: 2010/09/09
    ジャーナル フリー
    The case had furuncle, and had it insufficiently incised by a surgeon. The lesion did not cured favorablly, therefore, the paticnt visited our Clinic with complaints of high fever and pain. At our Clinic, we learnt that the case is diabetic, and that, due to insufficient dranage of pus, the lesion had already caused an adjoining metastasis in the cranial periostium, thus causing a severe periostitis.
    For the treatment of this disease, which is generally considered to be of unfavorable prognosis, we extended the incision, and made a counter opening through which a large dose of penicillin and sulfa drug together with insulin. Thus the periostitis was successfully cured within a short period of time and, further, the diabetes became much milder.
  • 中沢 進, 新井 藏吉, 笠原 千鶴子, 沼尾 欣一, 月岡 三郎, 荏原 章悟, 松島 貞夫, 高野 修
    1953 年 13 巻 4 号 p. 295-296
    発行日: 1953/12/01
    公開日: 2010/09/09
    ジャーナル フリー
  • 主として血色素量を中心として
    渡辺 富雄, 岡 亨, 江連 しげ
    1953 年 13 巻 4 号 p. 297-298
    発行日: 1953/12/01
    公開日: 2010/09/09
    ジャーナル フリー
  • 吾妻 俊夫, 岡 亨, 渡辺 富雄, 江連 しげ
    1953 年 13 巻 4 号 p. 298-299
    発行日: 1953/12/01
    公開日: 2010/09/09
    ジャーナル フリー
  • 浜田 彰彦, 大内 繁, 中村 曉史, 梅津 吉治, 内村 良二, 中沢 進, 竹田 礼二郎, 田辺 子男, 福留 勇, 鈴木 茂, 坪井 ...
    1953 年 13 巻 4 号 p. 300-301
    発行日: 1953/12/01
    公開日: 2010/09/09
    ジャーナル フリー
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