昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
31 巻, 7 号
選択された号の論文の5件中1~5を表示しています
  • 1.脳シンチグラム
    北原 隆, 宗近 宏次, 菱田 豊彦, 会田 巌, 馬場 康弘, 志村 秀夫, 古賀 靖, 土屋 武郎, 平林 晋一, 許 端光
    1971 年 31 巻 7 号 p. 333-341
    発行日: 1971/07/28
    公開日: 2010/09/09
    ジャーナル フリー
  • 山口 明志
    1971 年 31 巻 7 号 p. 342-352
    発行日: 1971/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    本態性高血圧に対する中枢神経性機序すなわち中枢神経系の血圧変動への影響を検討する目的で本態性高血圧患者18名, 正常血圧者9名, 計27名の自然睡眠時における脳波, 血圧, GSR.眼球運動, 呼吸, 体温, 脈波, 心電図を同時かつ連続的に行ない, ポリグラフを作成し各相関について検討した, その結果本態性高血圧患者は脳波的睡眠深度に平行して著明に血圧下降しこの血圧変動と同様に脈拍, 脈波, 呼吸, 体温も変動することを認めた.GSRはこれらと逆相関を示し, なおかつ深睡眠時には手背に頻度, 振幅ともに優勢であつた.またparadoxical sleepにおいて眼球運動はrapid eye movementが出現し血圧は10mmHg前後の変動が細かく生じる同時にこの時期において脈拍, 呼吸は増加するGSRは僅かな頻度となる.正常血圧者の血圧は下降するがその下降は著明でない.moderately deep sleep, very deep sleepになると血圧下降は, より僅かな下降で本態性高血圧患者と明らかな違いを示した.また脈拍, 脈波, 呼吸, 体温, GSR, 心電図等も本態性高血圧患者が示した経過と同様な変動を認めるが, その変動はすべて本態性高血圧患者に比し著明でないことを認めた.これらのことからも中枢には血圧調節機構に関してHomeostasisがあつてそれはとりもなおさず血圧のリズム形成につながつていると考えられる.
  • 宝樹 啓掌
    1971 年 31 巻 7 号 p. 353-360
    発行日: 1971/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    In order to know and understand the mode and mechanism of action of gold containing drugs pathological studies on resorption, removal and discharge of the drug from the kidney should prove to be value.
    Method of experiment:
    Sorganal (Schering A. G. CO., Germany) containing organic gold was administered by intramuscular injection into rabbits which were divided into three groups.
    i) group A......... (12.0 ml, 80 mg in all)
    ii) group B......... (23.1 ml, 154 mg in all)
    iii) group C......... (7.1 ml, 539.1 mg in all)
    The morphological changes observed in the kidney were as follows:
    1. Swelling of Malpighi tufts and exudate in Bowman's space were found in a slight grade in all cases of group A, but in groups B and C, these changes were of moderate grade with also edematous changes of intercapillary space.
    2. Slight deposition of gold granules in glomeruli were seen in most cases of group A, but in groups B and C, all cases demonstrated deposition being marked in some cases.
    3. Granular degeneration on proximal tubules were observed in all cases of each group being most conspicuous in group C.
    Vacuolar degeneration occurred in some cases in group A slightly, but in groups B and C mostly, moderately.
    4. Vacuolar degeneration of distal tubules was found in all groups. This change was especially remarkable in groups B and C. Two cases in group B revealed atrophy of tubular epithelia and 4 cases in group C showed necrosis.
    5. All cases showed deposition of gold granules in epithelia of proximal tubules. This was especially remarkable in one case in group B, 3 cases in group C, and moderate in 4 cases in group C.
    6. Deposition of gold granules in epithelia of distal tubules was of a milder degree as compared to that in proximal tubules.
    7. Desquamation of necrotic epithelial cells containing gold granules was observed in the lumen of distal tubules in 2 cases.
    8. The main changes in the present experiment were found in tubular epithelia being composed of vacuolar degeneration, atrophy and necrosis.
    This condition was interpreted to be compatible with nephropathy accompanied by a stimulatory invasion to blood vessels.
  • 森元 博久, 鄭 彰義, 細田 典夫, 金光 武彦
    1971 年 31 巻 7 号 p. 361-373
    発行日: 1971/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    Studies were performed on the effect of fat metabolism on a relapse of Vitamin B2 deficiency disease, and effectiveness of various kinds of Vitamin B2 preparation against such relapsed conditions.
    Results were obtained as follows :
    1) Symptoms of Vitamin B2 deficiency could be detected much earlier in the group of rat with relapsed Vitamin B2 deficiency disease as compared with those of incipient B2 deficiency disease.
    Also gain in weight and recovery from symptom of B2 deficiency after administrating Vitamin B2 preparation were observed to be delayed in former group.
    2) Total amount of Vitamin B2 in whole blood showed 4.5γ/dl (ester type, 3.5γg/dl) on the average on the first day of study in the convalescent stage.
    However, the average level of Vitamin B2 increased to 6.7γ/dl (ester type 5.7γ/dl) 25 days later, which revealed less lower than the average of 7.2γ/dl (ester type 6.4γ/dl) measured in the convalescent phase of the first experiment reported before. In case of dead specimen, total amount Vitamin B2 contained in whole blood showed average of 3.5γ/dl (ester type 2.5γ/dl) .
    3) After diet for relapse of Vitamin B2 deficiency food was given, the increasing rate of lipid in serum was much larger as compared with that of the first experiment which reported before.
    Especially, the group of rats fed by food which contained high amount of fat showed extremely higher level in serum lipid than those of groups which fed by medium and low amount of fat contained.
    Significant difference of variation in amount of lipid in sera among these three groups, however, was not observed.
    4) When Vitamin B2 preparation was given to the rats with relapsed Vitamin B2 deficiency disease, the delayed recovery from clinical aspects and improvement of fat metabolism were seen. Some of the rats died without showing any reactions even Free B2 daily or B2-Butylate every four days.
    As the conclusion, daily dispense of B2-Butylate for B2 dificiency disease is believed to be an excellent prescription.
    5) When symptom of B2 deficiency disease relapses, it tends to get worse very quickly and a high degree of B2 deficiency can be observed.
    Thus, if the B2 preparation is not given at a proper time, it will be longer be effective and complete recovery could not be expected when B2 preparation is dispensed after tissues have already changed.
  • 太田 宏, 安藤 彰彦, 前田 洋, 李 雅弘, 李 鴻謨, 尾上 保夫, 青木 隆一, 高場 利博, 岩堀 嘉和, 松下 功, 唐沢 弘文 ...
    1971 年 31 巻 7 号 p. 374-379
    発行日: 1971/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    Two cases of penetrated wound was reported.
    First case, 37 years old man, was shoted with peg, intraperitoneal cavity and liver injury was existed.
    In the another case, 22 years old man, the foreign body was existed in the right ventricular muscle, and it was taken off using heart-tung by pass.
    They were all survived.
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