昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
29 巻, 2 号
選択された号の論文の6件中1~6を表示しています
  • 松永 〓
    1969 年 29 巻 2 号 p. 67-77
    発行日: 1969/02/28
    公開日: 2010/09/09
    ジャーナル フリー
    The ureter of guinea pig was stimulated by the rectangular pulse, and the effect of stimulation was detected by the appearance of the action potential as an indicator.
    Relation between the voltage of rectangular pulse and excitation time (t) was favored of Weiss's experimental formula. The values of chronaxie were 18 msec and 22 msec, which were considerably longer than that of nerve or skeletal muscle fiber. But if the values of respective chronaxie were adopted as the unit of excitation time, the V-t relation of ureter was similar to other excitable tissues. There is no essential difference in the process of excitation among those tissues.
    But the excitability is not the same along the entere length of the ureter. V-t relations are different from part to part along the ureter. It is supposed, as the results, the velocity of the propagation of action potential is not constant along the ureter, and that fact was proved experimentally.
    The strength of action potential at the stimulated part is weak, however it grows up to its full strength in the way of proagation.
    The true latency which means, according to the present author, the time from the end of the excitation time to the appearance of action potential at the stimulated part, was measured. The true latency was several hundred msec.
    If the voltage of the stimulating current is kept at constant, the true latency shortens depending on the duration of the current. Relation between the true latency and the duration of stimulating current is hyperbola, and is favor of Weiss's experimental formula.
  • 高尾 利国
    1969 年 29 巻 2 号 p. 78-87
    発行日: 1969/02/28
    公開日: 2010/09/09
    ジャーナル フリー
    Sodium nitrite which is known as an important agent in causing hemoglobinopathia was administered to rabbits by injection in a daily dose of 40 mg, 60 mg and 80 mg/kg, and the changes of the brain from the acute to chronic stage were studied histopathologically. Acute swelling of nerve cells of the cerebral cortex in the acute stage was more remarkable than in the chronic stage in all groups, but liquef actives, vacuolar and def ormative changes of nerve cells in the chronic stage of 60 mg group were more significant than in the others.
    Vacuolar degeneration of choroidal epithelium and edema of the interstitium were as remarkable as in the meninges in the acute stage, but the changes in the large dose and those of long term group were of the highest grade.
    The pathologic changes induced by the disturbance of secretion and circulation of cerebrospinal fluid reflected the hypoxic influence of this drug rather than those of the nervous tissue in varous areas of the brain.
    The hypoxic lesion induced by the drug was most striking in the liquor-blood barrier.
    The hypoxic influence in brain occurs as a result of methemoglobin formation, and is relatively pure and standard type compatible with the secondary indirect type according to the classification (G. Watanabe) of disturbance by chemical substances.
    It is considered that this will be useful in estimating the pureness of toxic hypoxidosis.
  • 永友 知恵子, 北条 稔
    1969 年 29 巻 2 号 p. 88-94
    発行日: 1969/02/28
    公開日: 2010/09/09
    ジャーナル フリー
    The value of neutrophile alkaline phosphatase (N-A.P) of patients with diabetes mellitus was investigated and the results obtained were as follows.
    1) High value of N-A.P was observed in diabetic patients with hight blood sugar, much urine sugar and complication.
    2) N-A.P value obtained by addition of sugar in the blood was low in vitro study.
    3) N-A.P had no particular relationship between duration of disease, age, number of neutrocytes and cholesterol value.
  • 第VII報DM1→DMT1変異
    福留 勇, 野村 房子, 黒川 叔彦, 山田 耕一郎, 山野 幹雄
    1969 年 29 巻 2 号 p. 95-104
    発行日: 1969/02/28
    公開日: 2010/09/09
    ジャーナル フリー
    DM1 (Mucoid M) grown from Mutabile-type variant Murase originates a galactose resistant mutant of dwarf colony type. This mutant is resistant to galactose and differed from DM1 which is very sensitive to galactose. This kind of mutant was also found in Escherichia as well as in Salmonella. From the above reasons, this mutation is believed to be common among enteric bacteria and so it was designated as DMT1 in relation to DM1. Various characters of this mutant were investigated. The results obtained were as follows.
    1) Colonies of DMT1 on plane agar plate and even on galactose agar plate are dwarf type in size.
    2) Differed from DM1, DMT1 does not absorb galactose from the medium.
    3) DMT1 is not motile as well as DM1.
    4) In the acidagglutination reaction of Michaelis, the result of DMT1 is quite comparable to that of DM1.
    5) In fermentation test with various carbohydrates, the results of DMT1 show the similarity to those of DM1.
    6) DMT1 has tendency to restrain gas production in the fermentation of carbohydrates. And this kind of character is not influenced by the kinds of carbohydrates.
    7) Sensitivity of DM1 to Na2SO3 is transmitted to DMT1, just as it is.
    8) DMT2 originates MT-like mutant.
    9) It is not easy to explain directly the relationships between DM1 and DMT1 from the serological point of view, but MT-like organism which was grown from DMT1 seems to belong to the same species with DM1 in the agglutination reaction in case of Salmonella. This also explains the relationships between DM1 and DMT1 indirectly.
    From the above findings, it is believed that DMT1 is a new type of mutant which belongs to the Mutabile-type variation of Murase.
  • 前田 正雄
    1969 年 29 巻 2 号 p. 105-118
    発行日: 1969/02/28
    公開日: 2010/09/09
    ジャーナル フリー
    In an attempt to study the effect of mechanical loading on a developing hip joint, the hip joints of young rabbits were fixed in a flexed, abducted and externally rotated position admitting of some motion and subsequently were examined for changes macroscopically, histologically and roentogenologically as well as by utilizing tetracycline labelling technique, contactmicroradiography and microangiography. The results were summarized as follows:
    i) There were flattening of the articular head of the femur, steepening and enlargment of the posterior portion of the acetabular roof, retroversion of the femoral neck and thickening of the joint capsule noted. These changes were considered to represent dysplasia occurring to sustain competence of the joint in such an unusual position. The dysplasia of the head of the femur was preceded by the deformation of the acetabular roof.
    ii) Histological changes were most prominent in the epiphyseal plate, followed by the articular cartilage. The acetabular roof and the articular cartilage of the femur, which constitute the articulation, showed degenerative and atrophic changes without demonstrable pressure necrosis. The epiphyseal plate of the femoral head responded to the exercised pressure with gradual enchondral dysostotic changes.
    iii) The first 5-week period was marked by degenerative and atrophic changes of a mild degree, while the subsequent periods were characterized by regressive degeneration of increasing intensity.
    iv) Tetrcycline labelling and microradiography provided biophysical evidence of impaired ossification.
    v) Whereas the fixation of a young hip joint in non-functional position causes the joint to develop in the direction of forming an articulation which is competent for such unusual conditions, its fixation in a position which allows the movement of the joint diminishes the risk of necrosis of the head of the femur.
  • 主として椎体侵襲による治療成績について
    安藤 公信, 佐藤 哲平, 大野 貞夫, 稲生 勝司, 阪本 桂造, 上村 正吉
    1969 年 29 巻 2 号 p. 119-122
    発行日: 1969/02/28
    公開日: 2010/09/09
    ジャーナル フリー
    The authors reported in two times on the statistical observation on the treatment and prognosis of the tubercurosis of the spine treated in our clinic during the past 25 years. This time the authors report the statistics on our experiences of the past 30 years of the treatment of the tubercurosis of the spine and prognosis of the patient treated by curettage operation arriving directly in the focus. In the present time the authors beleave the focal debridment is the best treatment under progressed narcosis and chemotherapy today.
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