Employing a total of 29 female dogs, partial nephrectorny was applied (success in 21 and failure in 8 cases) for the observation of the postoperative recovery of renal functions as well as for the observation of the influence, when the operation was given on one side, on the other side of the kidney by individual renal clearance. An investigation was made also on the techniques of operation. In most cases, the suture of the cut surfaces was done by the suture of the fibrous capsule alone. Three different groups were provided, namely, (1) sutures given after insertion of a piece of muscle, (2) sutures given after insertion of a piece of fat, and (3) sutures given without any insertion, for the comparison of the state of recovery in their renal functions. For collection of the separated urine, a balloon catheter of special made was used. For renal clearance test, morever, 20 cc of 10% sodium- p-aminohippurate and 100 cc of 10% sodium thioslfate were given by continuous interavenous instillation the obtain the renal plasma flow (RPF) from the former and the glomerular filtration rate (GFR) from the latter. Filtration fraction (FF) was calculated from GFR/RPF and the renal blood flow (RBF) from the formula RPF × 100/100-Ht
Following conclusions were drawn from the finding of the experiments stated above:
1. As preliminary experiment, normal individual clearance was determined. In the right kidney, GFR was 42.38-62.43 cc/min with the mean of 52.38 cc/min with the mean of 52.38 cc/min ; RPF was 218.84-142.37 cc/min with the mean of 179.42 cc/min ; and RBF was 212.49-347.36 cc/min with the mean of 269.36 cd/min While, in the left kidney, GFR was 45. 72-68.52 cc/min with the mean of 57.72 cc/min ; RPF was 161.58.227.52 cc/min with the mean of 192.13 /min ; RBF was 241.16-361.24 cc/min with the mean of 289.26 cc/min indicating that in the dog renal functions of the right kidney are higher than those of the left side.
2. On applying partial nephrectomy, the renal functions become lowest on the 3rd after operation. Improving function gradually thereafter they are restored to the normal values of before operation on the 21st day. Lowering of renal functions similar to the side received operation can also be observed on the normal kidney of the other side, this lowering, however, is much milder than side received operation.
3. Functional lowering of GFR is the lowest in the goup received no insertion.
4. Lowering of the renal function RPF is most remarkable in the group received muscule insertion, and its recovery too is much retard in this group than in the other two groups.
5. Recovery of the renal function RBF is the most retard in the group received fat insertion and even 21 days after operation it was still lower than that before operation.
6. Generally speaking, of the three groups undergone the present experiment, the one received no insertion showed adequate recovery and much milder lowering in renal functions than other groups.
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