The author extracted water soluble substances from 10 months placenta, 3 months chorionic villi and from vesicular mole by Matsubara's method, and confirmed the presence of their active component by means of qualitative reactions and intracutaneous reactions. Upon the above confirmations, these substances were injected into developing hen's eggs in order to investigate their influence on the growth and the liver of the developing chick embryos. The following results were thus obtained. 1. The injection of fraction P.X extracted from 10 months placenta acted on the growth of chick embryo neither promotingly nor inhibitorily. Further, no histological findings in the liver suggesting any toxic changes were noted. 2. The injection of fraction P.X extracted from 3 months chorionic villi acted on the growth of the chick embryo promotingly at the concentration of 5 mg, but acted inhibitorily at the concentrations of more than 5 mg. However, no influence was recorded at the concentrations less than 5 mg. In this case, pathological changes were recognized in the liver at a high concentration (10mg), which were considered primarily to be venous circulatory impediment due to direct absorption of fraction P.X. 3. The injection of fraction P.X extracted from vesicular mole acted on the growth of chick embryo promotingly at a relatively low concentration (0.625mg), but inhibitorily at higher concentrations. However, it did not cause any pathological changes in the liver.
The case is a 18 year-old male, who was suffering from the thrombosis of Sinus transversus, Glomus venosus juguli and V. jug. int. following pearl tumor. The case, however, had been given treatment under a mis-diagnosis of Griesinger's syndrome, and was completely cured by Grunert's operation.
Relative to the results of “Koha” treatment of the oto-rhino-laryngological diseases, reports have heretofore been published very scarcely. The author has been very much interested in the “ Koha” treatment since the time when he was a student of the former Army Medical College. The author was given “Koha” by one of his friends, and administered the preparation to several hundred cases, mostly per orally. In the present paper, the author makes a statistical observations on these cases. The author also takes this opportunity to express his sincere appreciation to Dr. Koba of the Baltimore Municipal Hospital for his kind advice to this work.
The author succeeded to protect the local skin against radiation damages applying 10-3M glycerin solution of cysteamine in the cases of post operative x-irradiation of mammary cancer. By the method described in the present paper, the author was able to increase the doses up to 1.5 times as much as those given in the control cases. Regarding the optimal concentration of the agent and the restoration and treatment of the erosions, favorable reports are being prepared to be published soon after.
Case 1. A 29 years old female. Since 1 week, she had been complaining of a feeling like a foreign body and pain on her larynx. Swelling and redness were observed on the right lingual surface of epiglottis, The ailment healed after incision under indirect laryngoscopy. Case 2. A 35 years old male. The case had been complaining of itching on the pharynx since 2 days. On examination, yellowish-red swelling was observed on the ligual surface of the epiglottis. The lesion discharged pus spontaneously and healed. Case 3. A 51 years old female. Since 10 days, the case had been complaining of a feeling like a foreign body on her larynx and pain in swallowing. On examination, redness and swelling were observed on the right lingual surface of the epiglottis. The lesion was cured by the treatment with antibiotic preparation. The present paper deals with the statistical observations on the above 3 cases in addition to 39 cases reported in the literatures in Japan regarding their causes, inducement, age, sex, prognosis and treatment.