One case of stenosis of pulmonary cone (Keith's infundibulum) autopsied recently at the Tokyo-to Medical Examiner Office is reported. The cardiac malformation under discussion was encountered in a 22-year-old student dier suddenly and in this heart the ventricular septum was closed. In the narrowed site of the pulmonary cone, the myocardium of ventricular wall was strongly hypertrophied and even the well developed abnormal trabecle was bridged across the narrowed pulmonary cone and no inflammatory changes were there evident. The authors have assumed, therefore, that the stenosis in this case might have occurred rather on the basis of congenital developmental anomaly than as a result of bacterial endocarditis.
On investigating the uropepsin (U. P.) content of varying disorder, especially, gastric disorders, U. P. values were found to have a diagnostic value on gastric cancer and at the same time to give some valuable information for the treatment of various disorders, especially, gastric disorders. 1. U. P. values of cancerous disorders were mostly low, while those of ulcers were high with broader distribution. Patients of gastritis sometimes showed low values with fairly broad distribution. Patients of appendicitis were divided into two group of low and high U. P. values. Mild cases of pulmonary tuberculosis, moreover, were found to have broad distribution. Accordingly, U. P. values were found to be valuable not as a measure for differential diagnosis but as that of knowing the clinical status of individual patient. 2. In the patients of gastric disorders, gastric pepsin (G. P.) changes in parallel to U. P. in most cases, but in some cases it does not, which might probably due to the influence of adrenal functions and such cases were the patients of gastric cancer or ulecr. 3. Gastric acidity has a lesser degree of parellel relationship to the U. P. content than it does to G. P. Most cases showing nearly no pararellism. 4. Those who showed abnormality in Thorn Test possessed low U. P. values and those without any parallelism between G. P, and U. P. were found to have some disorders of the adrenal functions. Thorn Test abnormal cases were predominant among the patients of gastric cancer. 5 In contrast to appendectomy, U. P. values after gastrectomy show larger increase for longer period. No specific tendency was recognized, however, on the appearance of the peak of this increese. Patients of cancerous disorders showed small deviation in U. P. values.
Investigations were made on the influence of several drugs on uropepsin (U. P.) as well as on the relationship between urodiastase and U. P. 1. Imidalin : Influence of Imidalin injection was investigated by the changes produced in the gastric acidity and U. P. content. U. P. showed an increase when the acidity at the time of hunger was above 20 even though the maximum acidity by the injection of Imidalin was above 31-61. While all the others, showed a decreasing tendency instead. 2. Adrenochrom, c preparation: U. P. content decreased by the administration of adrenochromic preparation temporarily but increased thereafter. 3. E, nzynolum: U. P, showed a moderate increase 2 days after administration of Enzynolum. 4. Urodiastase and U. P.: Both Urodiastase and U. P. showed a tendency to increase after operationn though there existed no parallelism between them.
1. Among barbiturates used in conjunction with the electrical shock treatment, methylhexabital is found to be the most practical in terms of deepness of the narcotic effect, degree of reducing the convulsion, affecting time, ect. 2. The strength of the convulsion can be acculately grasped by measuring the length of the convulsion time, as the strength is quite proportional to the length of its duration on the kymogram, led from the biting muscles in convulsion. 3. By making necessary changes in the amount of an injection or the injection speed, the strength of the convulsion can be adjusted at will. Therefore, a full consideration must be exercised in deciding the amount of an injection and the injection speed appropriate to a specific purpose in applying the electrical shock treatment under narcosis. 4. By using methylhexabital with the precautions mentioned above a fracture of bone and other undesirable side effects are avoided, and at the same time, this will enable a safe treatment even on a patient suffering from hypertension, thus the scope of applications of the electrical shock treatments is expanded. 5. It was found that reducing the convulsion centrally by using barbiturate would result in the lessening of various biological changes, and concureently with this the effectiveness of the treatment will also decrease. 6. To administer the narcosis using barbiturates to a patient only for the purpose of removing the fear of the electrical shock or preventing the refusal, it is advisable to apply the electrical shock treatment after a proper period of time (according to my estimate, about 5 minutes after the patient was administered methylhexabital) or when the effect to reduce the convulsion is expired. 7. In order to prevent the psychomotor excitement after the convulsion, an injection of arbiturate after unmodified electrical shock is effective. 8. when d-tubocurarine chloride is used in the electrical shock treatment, the convulsion will decrease. In this case as the central impulse in the brain will not decrease, biological changes will not be lessened in proportion to the extent of decrease in convulsion. Thus the therapeutic effect is better than that of the electrical shock under narcosis with barbiturates, however, as a full control of the convulsion using this medicament would involve a risk of causing a paralysis in respiratory muscles and is therefore practically imposible, it is considered that this treatment is after all not better than the electrical shock treatment under narcosis using methylhexabital. 9. The non-convulsive electrical stimulation therapy is not so effective as the usual electrical shock treatment, and even though there is some value in applying it for an acute poisoning from hypnotica and apnoea after the electrical shock, the treatment is not in the same category as the electrical shock treatment in respect to the mechanism.
Further investigations were made on the pharmacology of S-benzoylthiamine O-monophosphate (BTMP) and the results obtained were as follows: Intracisternal injection of BTMP in a dose of 2.5-5.0 mg/kg produces the excitement of respiration and the increase of blood pressure. In the rabbit, BTMP solution above the concentration of 10-3 gives an inhibitory influence on the auricles of the heart. In the rabbit, intravenous injection of BTMP gives no influence on the body temperature but gives a diuretic action. Absorption of BTMP from the large intestine by enema is good.
Employing the method of Guthmann and that of Martius, pelvic pictures were taken on a total of 357 pregnant women. Besides, pubic pictures were taken on 96 non-pregnant women. Measurements on the films thus taken were converted into actual measurements by proportional calculation. Sacral shapes were classified into 5 groups of 14 types and the shapes of pelvic inlet were observed following the clasfication of Caldwell. Morphological and clinical findings thus obtained were subjected to the stochastic disposition. Results obtained were as follows: 1. Arcate sacrum was predominant followed by linear, navicular and second promontory in the order listed. 2. Frequency of the appearance of flat sacrum was 30%, tubif orm pelvis 6.7%, funnel pelvis 16.5% and long pelvis 9.9%. Tubiform pelvis was mostly observed with nevicular sacrum and funnel pelvis with navicular and linear sacrum. 3. Advanced funnel pelvis was often found with the pelvic inlet of platypelloid or anthropoid type in the rear portion of the pelvic inlet. 4. Most of those with relatively narrow public arch angle were found with advanced flat sacrum. 5. Mean of the obstetrical conjugate was from the 11.60 cm for BB type to the 12.69 cm of 6F type. 6. Some of the women possessed navicular or linear sacrum showed a mean of the conjugate of pelvic expansion shorter than the obstetrical conjugate. 7. In the present study, it was difficult to recognize any significant difference between the sacral flatness, long pelvis, tubif orm pelvis, funnel pelvis etc and normal labor, forceps labor, cesarean section etc. Incidences of cearean section and forceps labour, however, were predominant among the women with linear pelvis or second promentory pelvis. 8. Incidence rate of cesarean section was high among the women with obstetrical conjugate less than 10.5 cm and the conjugate of pelvic expansion 11.2cm. In view of the findings stated above, it is concluded that particular cares should be taken as to the placement of the fetal cranium in the pelvic inlet at the beginning of labor for the women with contracted pelvis, linear sacrum or with second promontory.
Histpathological investigations were made on the surgical disorders of the anorectum, namely, 27 cases of non-cancerous disorders, 77 cases of rectal cancer and 1 case of rectal monopolypoid cancer. Histological survery was made on the rectum and the anus of the 27 non-cancerous cases. No significant difference was recognized by the difference of age. While, remarkable difference was recognized on the epithelium between the non-cancerous cases and the cases of rectal cancer. In contrast to a total of 67 polyps found on the 17 cases (22.0%) of rectal cancer, of which 20 found on 6 cases (30%) were malignant, not a single polyp was found among the patients of non-canerous patients. Pictures of inflammation were recognized on the 11 cases (14.3%) of rectal cancer, but there was not a single case among the non-cancerous patients. Epithelial metastasis of the mucous membrane was recognized on 3 cases (11%) of non-cancerous patients, while 31 cases (40.5%) were found to have this metastasis among the patients of rectal cancer. Anal disorders were present in both of them but the incidence rate of non-cancerus patients was slightly higher. Statistical observation and histopathological survey were made on the frequency of the apperance age, symptoms, duration, diagnosis, operation and the distal result of the patients of rectal cancer. In connection with the histogenesis of rectal cancer, moreover, pathohistological investigation was made on the basal ground for the development of cancer through the survey made on the possibility of the malignant change of the polyp accompanying rectal cancer, monopolypoid cancer, ulcer, metastasis etc.
X-ray pictures of the pelvic inlet were taken following the methods of Martiu and Guthmann. Measurements on the films thus taken were converted into actual measurements by proportional calculation to obtain mean measurements and their deviations of varying conjugations. Shapes of the pelvic inlet were classified into 5 groups of 14 types for the stochastic obseruation of the morphological and clinical findings. Results obtained were as follows. 1. Regarding the shapes of pelvic inlet, frequency of the appearance of gvnecoid type was 73.3% platypelloid-gynecoid type 12.2%, gynecoid-android type 3.6%, platvpelloid type 3.3%, android-gynecoid type 1.3%, platypelloid-anthropoid type 1.0%, anthropoid type 0.7%, anthropoid-gynecoid type 0.7%, and platypelloid-android type 0.3%. 2. Gynecoid and anthropoid types showed low pelvic index. All cases of platypelloid type showed high index in the front but 25.5% of them showed low index in the rear portion. While, android type showed low index in the front but high index in the rear portion. 3. When the space available for the fetal cranium in the plane of the pelvic inlet was expressed in the term of the maximum circumference, the most favorable type was gynecoid. Platypelloid type was narrow in the vertical conjugate, android type was defficient in the vertical conjugate in the rear and also in the horizontal conjugate of the front, and anthropoid type was insufficient in the horizontal conjugate. 4. Platypelloid and android types, in the plane of the pelvic inlet, have no association with the platypelloid sacrum. Side curve of the first sacral vertebra does not run in parallel with the vertical curve of the sacrum. There was no practical difference, moreover, in the frequency of the appearance of tubiform pelvis and funnel pelvis by the difference of the shape of pelvic inlet. Of funnel pelvis, however, those with platypelloid or anthropoid type in the rear portion of the pelvic inlet were strongly funnel shaped in many cases. 5. Mean of the vertical conjugate was from the 12.39cm of anthropoid-gynecoid type to the 9.21cm of the android-gynecoid type. Mean of the horizontal conjugate was from thel2.92cm of platypelloid-android type to the 10.18cm of anthropoid type. 6. Those flat in the rear portion of the pelvic inlet showed higher incidence rate of cesarean section and generally required longer period of labor. 7. Those with pelvic conjugate less than 10.5cm were found to show higher incidence rate of cesarean section.
Per os administration of glucuronoamide was found to have an inhibitory influence against the development of hepatic disturbance induced in mice by the administration of carbon tetrachloride. Carbon tetrachloride was injected in combination with either one of glucuronoamide, glucuronolactone or sodium glucuronate and the inhibition of the development of hepatic disturbance was recognized with the combination of tetrachloride and sodium glucuronate. Hepatic disturbance induced by carbon tetrachloride was moderately inhibited by glucuronoamide injections repeated for 5 times and considerably by repeating the injections for 7 times.
Stated in the folliwing are the findings of the statistical observation made on a total of 7, 702 female students covering all the districts in Okinawa. 1. Mean age of menarche was 14 years and 7 month and it was observed mostly in the age of 14 years followed by 13 years. This mean age was equivalent to most of the post-war reports made in the Japan proper. 2. Staistical significant difference was observed in the age of menarche by district, namely, it was rather early in Yaeyama district, urban district of the main island and also in the southern, northern and middle parts of the main island, while it was rather retard in Miyako island. 3. Significant difference was also observed by the difference in family occupation. Namely, the menarche appeared earlier in the families of general salaried people, free occupation, mineral industry and commerce, while it was retard in the families of agriculture, forestry and fishery. These findings were in agreement with previous reports. 4. Menstrual cycle was mostly 30 days type occupying 45.930 followed by 28.47% of 28 days type. Its mean was 29.28% and was in agreement with other reports. There was no significant difference by district or age. 5. As for the regularity of menstrual cycle, 85.12% were regular and 14.88% were irregular. The rate of irregular cases was lower than that of the other reports. There was no difference by district. 6. Mostly, the menstrual amount was medium occupying 75.77%. There was no significant difference by age or district. 7. The period from menarche to the second menstruation was mostly 1 month being observed in 32.63 %. In most cases, moreover, the second menstruation was observed within 6 months. The period from menarche to the second menstruation was shorter among younger girls than that of the elder ones and this relationship had statistic significance. 8. Menstrual duration was mostly 4-5 days being observed in 59%. Those with the period lasting 1-3 days and 6-7 days were found in nearly 20% each. Those with lesser menstrual amount showed shorter menstrual duration and this relationship was staistically significant. There was no difference by age and district. 9. Menstrual distresses were observed in 84.83%. This figure was relatively high in comparison with that of the other reports. As for the intensity of those distresses, those unable to work were found in 4.19%, lower abdominal pain in 46.41% and the others were general fatigure, lumbar pain and headache in the order listed.
Mucoid colony variants and dwarf colony variants were isolated from the Mutabile type variants of enteric bacteria by mutation and investigations were made on their mutual relationships. Appearance of the Muc. colony was recoenized when pure cultures of the Mut. variants of Seim. typhi-murium and E. eoli were seeded and incubated on Endo' s plates or galactse-Endo' s plates for 24 hours and then left stancing in the room temperature for 2-3 days. This colony was mucoid on Endo' s or galactose-Endo' s plates but formed D colony on plain agar plates becoming non-mucoid. It was discovered that when Muc. type undergoes reverse mutation to Nonmuc. type, it becomes the starting Mut. variant and at the same time loses the characters of D type. On titrating the sensitivity of each variant against galactose, it was founc that the Muc. variant shows a rather low titer in comparison with that of the starting Muet. variant or reversed Mut. variant but its lactose sensitivity remains unchanged (Muc. varian of E. Coli Mut. variant) . Muc. type, of course, undergoes variation to the galactose resistant form MT of Murase. This MT, however, is D type and not Muc. type. It was discovered, further, that this D type MT undergoes variation to the same MT as that of the starting Mut. variant. Moreover, MRT mutation of Fukutome et al was recognized on the Muc. type of the Mut. variant of E. coli. This RT formed the mucoid colony also on plain agar plates. Non-mucoid D type was discovered by mutation from a strain of the Mut. variant of salm. enteritidis. This variant was highly sensitive against galactose. Both MT and RT of this variant were also D type. In view of the findings stated above, it can be said that the mucoid character observed on the Muc. variant of the Mut. variant is liable to accompany the dwarf character and becomes relatively resistant against galactose but not against lactose. Reverse mutant of this mucoid type is no more D type nor Muc. type. The newly appeared characters (mucoid or dwarf) of the Mut. variant seem to be transmitted to the following generation of the mutation (to MT or RT) whether or not they are disposed at the time of this reverse mutation.
On comparison of the mortality of chick embryos between INHG and INAH, the toxicity of INHG was found to be lower than that of INAH and the growth inhibition due to the administration of INAH was found to be moderated by its administration in the form of INHG. On quantitative determination of INAH contained in the allantoic fluid, in either case of the administration of INAH or INHG, the amount of excretion was found to increase following the increase in the dose administered and the maximum excretion during the course of incubation was observed in the middle stage. Increase in the hepatic weight was better among the embryos administered of INHG than those received INAH but the amount of INAH contained in the liver was larger among the embryos administered of INAH than those received INHG.
752 benzene workers were medically examined. The following results were obtained. 1) The young fellow occupied an overwhelming majority in benzene work. 2) The mean of the specific gravidities of blood and plasma and the numbers of red cells and leucocytes is slightly lowered, and the width of its distribution is larger than that of the health. 3) Anemia is frequently appeared among young and old workers, coproporphyrinuria is frequently appeared in youth. 4) Expecting age difference, benzene poisoning is appeared in an early stage, and its adaptability is clear.
The preventive effect of glucuronic acid against aniline poisoning was investigated with rats. The following results were obtained. 1) The decrease of the body weight by aniline poisoning was somewhat protected by the administration of glucuronic acid. 2) Anemia by aniline poisoning was also protected, but the increase of methemoglobin ratio was not influenced by the administration of glucuronic acid. 3) Glucuronic acid protected the decrease of the glycogen content in the liver, and it also somewhat protected the decrease of reduced glutathion in blood.
95 benzene workers were clinicalcy examined 4 times during 2 years. The following results were obtained. 1) A single pathological symptom is frequently appeared in slight benzene poisoning. 2) Benzene poisoning makes frequent appearance in benzene workers and few individual difference was observed. 3) Leucopenia and coproporphyrinuria are appeared in the early stage and anemia is appeared in the late stage in the benzene poisoning. 4) The pathological cases in each clinical examination frequently have complicated symptoms.
Clinical and histopathological investigations ware made on the wall of the jejunum and related mesenteric lymph nodes of operation cases in whom the infestation of hook worms had been confirmed by the presence of eggs in their feces or by the detection of the hook worm on the intestinal wall. Stated in the following are the results obtained thereof: 1. Infestation of hook worms causes the development of subacute or chronic inflammatory changes on the upper jejunum. Histopathologically, those changes are characterized by the appearance of relatively marked infiltration of eosionophiles in each layer of the intestinal wall. 2. Following the changes produced on the intestinal wall, regional lymph nodes are found to be enlarged showing the state of sinus catarrh and chronic lymphadenitis histopathologically characterized by the marked infiltration of eosinophiles. 3. intensity of these changes appears in proportion to that of the infestation of the hook worms and they can be the cause for the development of various digestive symptoms such as epigastric pain, nausea, vomiting etc.
1) The author divised a modification of E S. T. in which the shock was given just at the moment when the effect of S. C. C. reached the peak and at the same time the central anticonvulsive action of Thiamylal Natrium, a ultra-short narcotic, vanisched. The timing of the administration of both agents and electrigation was determined accurately so as to fit this purpose. 2) In this method E. S. T. is administrated under complete musclar relaxation, nevertheless, the feeling of suffocation accompanying strong anxiety, besides the reduction of therapeutic effect and the danger of respiratory paralysis due to Barbiturates could be perfectly prevented. Therefore it is regarded not only as a ideal clinical procedure, but as a beneficial method for the investigation of central changes induced by E. S. T. without the influences of general convulsion. 3) The symptoms of autonomic nervous system i. e. pulse, blood pressure, pupilary finding etc. and the findings in C. B. C. observed in the course of this treatment were just the same as those in unmodified E. S.. This proves the fact that there is no central inhibition of convulsion, and that muscular convulsion has nothing to do with the changes described above. 4) The change of blood sugar induced by this method was far less than that by unmodified E. S. and less than that by E. S. under narcosis with Barbiturates. It was clarified that the change of blood sugar should be regarded as induced, not centrally as believed hitherto, but by the muscle action during convulsion. 5) The electrocardiogram showed tacnycardia and a little elevation of ST and T waves in V1 record, during convulsion. 6) The brain wave showed in complete spike and wave complex during convulsion. This finding, alike the electrocardiogram above mentioned, is significant as that gotten during electroshock therapy without influence of muscle discharge and narcosis. 7) It was recogneized that the therapeutic effect of this method was superior to that of unmodified E. S. and E. S. under narcosis with Barbiturates, judging from the numbers of treatments that were enongh to bring about full remission of depressive patients. It is presumed that the effectiveness tdepends upon the length of the duration of convulsion.
With an intention of clarifying the relationship of functions between autonomic nerves and oirculatory organs at the time of pregnacy, Bickenbach test, Aschner test and cold pressure test were applied on a total of 69 pregnant women of normal pregnancy, pregnancy hypertension and pregnancy toxemia in combination with the recording of the blood pressure wave of the brachial artey and electrocardiogram for the observation of the autonomic nerve functions at the time of pregnancy as well as the changes produced by the loading of tests mentioned above on their circulatory functions. 1. As the result of Bickenbach test, the patients of pregnancy hypertension and pregnancy toxemia were frequently found to have vasomotor nerve disturbance. 2. Frequent appearance of abnormality in the arterial blood pressure waves of pregnancy toxemia indicated the increase in the cardiac load, increase in the peripheral resistance, lowering in the cardiac functions and the presence of spasms or sclerosis in the patients of this disease. 3. Aschner test positive cases were predominant among the patients of pregnacy toxemia and the influence of this test on the arterial blood pressure wave was the elongation of diastolic stage and the lowering of the minimum pressure resulting in the elevation of various portions of the wave. 4. Cold pressure test positive cases were predominant among the patients of pregnancy toxemia, especially, eclampsia. The main effect of this test on the arterial blood pressure wave was the appearance of the wave of elastic or the diminution of the diastolic stage. In view of the findings stated above, the patients of pregnancy toxemia were found to show a marked increase in the peripheral resistance and the instability of vasomotoric nerves. 5. As for the relationship with electrocardiogram, the time of wave transmission was found to be retard by the cold pressure test.
Blue and white globulin substances were isolated from 10 folds reclistilled water diluted dog plasma with acetic acid precipitation at pH 5.9. The effects of globulin substances on rabbits were hematologically investigated. The results were as follow. After intravenous injection of blue globulin substances to rabbits, red cells in peripheral blood became microcytic and it's osmotic-fragility weakened. Increase in serum caeruloplasmin value was observed with an advanced anemia following intra-venous injection of blue globuline substances which showed a marked fibrinolytic activity, moreover, oxidase activity of caeruloplasmin as diamine oxidase was investigated.
Aminosulfonic acid or its derivative such as 1-amino-2-oxy-propanesulfonic acid, 1-monomethyl-amino-2-oxy-propanesulfonic acid, 1-dimethylamino-2-oxy-propanesulfonic acid or the betaine of sulfonic acid was injected into the embryonating eggs either alone or in combination with nicotine and histological investigations were made on the heart, lung and the thyroid of the developing chick embryos for the observation of the influence of those preparations alone as well as the influence of their administration on the histological changes produced by nicotine. The results obtained were as follows: Administration of aminosulfonic acid or its derivatives generally causes the cellular infiltration in the pericardium and the proliferation of connetive tissue cells in the myocardial blood vessels. Their administration in combination with nicotine inhibits the development of myocardial vacuolar degeneration which can be observed by the single administration of nicotine. Generally, moderate cellular infiltration is recognized in the lung and the bronchus of the embryos received these substances. Formation of hydrops follows, moreover, the administration of the betaine of sulfonic acid or 1-dimethylamino-2-oxy-propanesulfonic acid. Their administration in combination with nicotine, however, results either in the alleviation or disappearance of such changes. Generally, 1-amino-2-oxy-propanesulfonic acid and its derivatives cause the proliferation of newly formed cells around the follicular epithelium of the thyroid. This change is especially remarkable when 1-amino -2-oxy-propanesulfonic acid is used and, moreover, the administration of 1-monomethylamino-2-oxy-propanesulfonic acid invites the loosening of the epithelial cells. Loosening of the epithelial cells is also seen when the betaine of sulfonic acid or 1-monomethylamino-2-oxy-propanesulfonic acid is used in combination with nicotine, but the combinations of nicotine with other substances produce no such severe changes. Namely, aminosulfonic acid and its derivatives generally produce similar histological changes on the homologous organs and there exists antagonism between those substances and nicotine.
Embryonating eggs received the injection of isonicotinyl hydrazide (INAH) and sodium glucuronate isonicotinyl hydrazone (INHG-Na) and the content of reduced glutathione (GSH) was determined on the eye ball, brain, liver and the muscle of the developing embryos for the comparison of the tissue GSH content between the administration of INAH and INHG-Na. Results obtained were as follows: 1. GSH content of the eye ball showed a tendency of moderate increase by the administration of INAH. Administration of INHG-Na showed no remarkable difference. 2. GSH content of the brain showed a tendency of slight increase toward the latter half of the incubation period by the administration of INAH. But the increase which followed the administration of INHG-Na was smaller. 3. GSH content of the liver and muscles showed an increase by the administration of INAH. But the administration of INHG-Na showed no remarkable influence. In short, both the administration of INAH and INHG-Na showed some influence on the glutathione metabolism of chick embryos but the influence of more toxic INAH was stronger than that of INHG-Na.
1. In the present experiment rabbits received the subcutaneous injection of diethyl-paranitropheny-thiophosphate in different doses of 4mg, 8mg and 12mg/kg body weight twice per week. Rabbits were classified into several groups by the difference in the dose administered, died or survived and further by the number of injections repeated for the comparison of the pathomorphological changes produced in relation to the concentration of the injection with emphasis on the ligual gland (Ebner gland) . 2. In both groups of died and survived, regressive changes of the glandular epithelial cells and the epithelial cells of the secretory duct became gradually severe following the increase in the number of injections repeated and the dose use. With the acticulum fibers of the basal membrane too, there was a slight enhancement in the findings such as crook. divergence, disconnection, disappearance etc. 3. Various retrogressive changes observed on the lingual gland in the present experiment are considered to be the result of tissue intoxicative influence dur to the hypoxydose caused by the administration of parathion. As for the mode of action of these toxic substances, they are considered to exert secondary immediate type action.
1. Normal pure bred rabbits were employed in the present experiment. They were divided into 4 groups of Group I intraperitoneal infusion of naphthaline-olive-oil, Group II vitamin C injection in combination with the intragastric infusion of olive oil, Group III administration of naphthaline powder mixed in vitamin C deficient diet (a) and normal diet (b) and Group IV subcutaneous injection of naphthalene -olive-oil. Then, histopathological studies were made on the heart of those rabbits. 2. Of the groups under long period observation, the myocardiac fibers of the rabbits in Group E showed fairly strong vacuolar degeneration and minute separation of the fiber as well as mild granular degeneration, swelling colliquative change, homogenization, atrophy, crumbling, irregular arrangement, hyaline degeneration etc. Those changes were slightly stronger than the changes observed on the group of vitamin C deficient diet. 3. Absorption of naphthalene administered by subcutaneous injection was poor in comparison with that of the oral administration and intraperitoneal infusion. This poor absorption is also indicated in the fact that the changes produced in the tissues by the changes produced in the tissues by the subcutaneous injection of naphthalene from the maximun dose of 30% (1g/kg) to the minimum of 10% (0.1g/kg) were extremely weak without too much difference.
1. In the present study, histopathological survey was made on the 8 fatal cases of 2 years to 70 years old of Folidol intoxication. 2. As for the sexual difference, there were 4 cases each of males and females. 3. Changes produced in the liver by the metabolic and circulatory disturbance are understood to be characterized by the histotoxic lesions developed by the hypoydotic action of the organic phosphorous. 4. Interstitial hydrops characterized by the interlobular collagenous fiber are understood as the basic picture for edemasclerosis, provided that the disease is prolonged, and it is considered to form an important factor for the advancement into sclerotic change in combi-nation with the reparative functions of tissue injury.
1. The author has introduced a newly devised procedure to cure various depressive states administering neuroleptics and psychotonics simultaneously, testified its effectiveness and discussedd the signification. 2. One hundred and forty cases were assigned to this study from those patients who received a complete course of this treatment under continuous and prudent observation. The results were as follows: improved 138 cases (98.5%), among them markedly improved 100 (71.4%), moderately improved 38 cases (27.1%) . Only 2 cases (1.5%) did not respond favorably. 3. Above mentioned super effects are presumably to be attributed to the fact that on this occasion by the combined administration of two kinds of agents which have apparently opposite action, undesirable side-effects are offset reciprocally, nevertheless favorable effects of the two mutiply each other. 4. The choice of drugs, their combination and dosage were determined in each case considering the etiologic factor and clincal feature at the beginning, but these were readily changed in accordance with the fluctuation of symptoms in the course of treatment. 5. By this method the depressive phase of affective psychosis could be remitted without shifting to manic phase. 6. The combined administration showed much higher ratio of improvement compared with that of single adminstration of so-called antidepresant such as Tofranil and monoamin oxidase inhibitors, and the psychopharmacological ground of this fact was discussed. 7. Though in some cases E. S. T, were applied, the numbers of application were very few, and in such cases the memory disturbances caused by E. S. T. which might often aggravate the hypochondric attitude of patients were recovered rapidly due to the action of psychotonics. 8. The psycherapeutic factors inevitably involved in the method were taken into full consideration.