昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
26 巻, 9 号
選択された号の論文の7件中1~7を表示しています
  • 藤沢 竜一
    1966 年 26 巻 9 号 p. 497-506
    発行日: 1966/09/28
    公開日: 2010/09/09
    ジャーナル フリー
  • 高尾 利弘
    1966 年 26 巻 9 号 p. 507-517
    発行日: 1966/09/28
    公開日: 2010/09/09
    ジャーナル フリー
    In the present experiment daily subcutaneous injections of either a 10 % or 30 % solution of naphthalene were given to rabbits consisting of 4 groups. Group I, II, III and IV received 0.1 g/kg of a 10 % solution 0.3 g/kg of a 10 % solution, 0.3 g/kg of a 30 % solution and 1.0 g/kg of a 30 % solution respectively. These rabbits were further divided into 3 groups according to the number of injections received ; group A (up to 10 injections), group B (up to 30 injections), and group C (more than 30 injections) .
    In the group given only a small amount of naphthalene and the group given a large amount during short period of time (group IV-C), edematous changes, swelling and thickening of the alveolar septum were in general mild On the other hand, the group given a large amount during a long period demonstrated marked changes.
    The alveolar wall was covered by PAS positive material, which in extreme cases escaped into the alveolar lumina. This change closely resembles to that found in hyaline membrane in infants and may help in understanding its developmental mechanism.
    Dilatation and iecomplete expansion of alveoli are probably due to hypoxia, and this phenomenon has a reactive significance in suplementing oxygen under an anoxic state. This finding was observed from the beginning in all groups.
    There are two types of incomplete expansion. The first type was found in the groups receiving only a small amount of naphthalene with only minimal morphologic changes of the alveolar septum. This type of atrophic lesion probably results from a respiratory disturbance under a hypoxic condition. The other type of lesion was found in the groups receiving a large amount of naphthalene during a long period.
    These consisted of cellular proliferation in the alveolar septum, distortion and narrowing of alveoli, which further accelerated the poor gas-exchange. The alveolar epithelia took an oval shape in both types.
    Accummlation of cells were found in the atelectatic areas, and these chiefly consisted of round originating from alveolar epithelial cells, adventitial cells and a small number of lymphocytes. Multinucleated giant cells were also encountered in some areas.
    Rarefaction of alveolar septum and the surrounding tissue of blood vessels, and edema are the basic changes found in hypoxia, while cellular proliferation is considered as a secondary change following edema and toxicity of naphthalene. The proliferation of cells in the alveolar septum is presumed to accelerate the development of pulmonary fibrosis.
  • 南雲 祐司
    1966 年 26 巻 9 号 p. 518-527
    発行日: 1966/09/28
    公開日: 2010/09/09
    ジャーナル フリー
    Results of macroscopic observation on the fetal chorionic vasculature of 76 cases of human placentas are described in this paper. This has been done with the aid of corrosion anatomical preparations.
    1. Umbilical veins concentrated most frequently in 3-branched form at the root (48.6±5.55 %) .
    2. On the running-type of chorionic arteries and veins, I type (radiant type) was seen in 39.2±5.91 % (artery) and 38.2±5.57 % (vein), II type (antler type), III type (outspread fan type), and branched tree type succeeded in order.
    3. As regards to the branching-type of blood vessels, radiant type was most frequently seen on the placentas of central of insertion of umbilical cord, and antler type and outspread fan type were relatively frequent on the lateral insertion.
    4. The communication between two umbilical arteries was situated near the insertion of umbilical cord at the placentas. The communication was absent in 3.9±2.22 %.
    5. As to the communication between two arteries, two types were seen : (1) the one with adhesive fusion between two arteries. Communication-branch was devided into 3 groups, and the fusion into 2 groups.
    6. The type with double communication-branch (never has been described) was seen in 2 cases (3.5 ± 2.45 %), which had one communication-branch between two main arteries with the communication-branch between one main artery and the second branch of the other main artery.
    7. Two umblical arteries had the communication for the most part near the insertion of umbilical cord and inside of placenta. Communications in the umbilical cord were rarely seen.
    8. Communication-branch and adhesive fusion between two umbilical arteries mostly had the length under 1.0 cm.
    9. As regards to the relation between first branch and communication-branch of umbilical artery trunk, the first branch started mostly after making the communication (82.2±4.51 %) .
  • 土肥 寿夫
    1966 年 26 巻 9 号 p. 528-542
    発行日: 1966/09/28
    公開日: 2010/09/09
    ジャーナル フリー
    Studies on the titer of Antistreptolysin-0 (ASL-O) with bacterial culture of streptococci from the throat swab were performed on 182 patients with streptococcal infections among children, 49 cases of non streptococcal infectious group with 148 cases of control during 1964 and 1965.
    Results were as follows :
    1) Ninety two percent of non-streptococal infectious group showed the titer of less than 100 units in ASL-O.
    2) In the control group, seasonal variation of positive rate on the culture for streptococci showed 28 % in winter while approximety 40 % in other three seasons. Highest rate for positive results of streptococci culture were obtained in the age of 8 years group.
    The highest rate in the titer of ASL-O was observed in summer followed by fall, spring and winter in order. Also higher frequency of positive rate was seen among the age of 4 to 7 years in age.
    3) In the streptococcal infectious group, following positve rsults were obtained :
    Acute respiratory illness : bacilli 90.9%
    ASL-O 24.1%
    Scarlet fever : bacilli 70.6 %
    ASL-O 29.4%
    Poststreptococcic state : bacilli 60.6 %
    ASL-O 72.7 %
    Rheumatic fever : bacilli 37.5 %
    ALS-0 87.5%
    Acute glomerulonephritis : bacilli 43.5 %
    ASL-O 78.4%
    Vascular purpura : bacilli 66.7 %
    ASL-O 62.0%
    The average of titer showed highest in rheumatic fever followed by vascular purpura, poststreptococcic state, nephritis, scarlet fever and acute respiratory illness accordingly.
    4) Whithin 4 th week of illness, titer raised up more than 250 units in 70.2 % of infectious group.
    It started to decrease within one to four weeks after beginning the treatment and reached normal value within 11 months thereafter.
    5) More rapid decreasing rate of, ASL-O titer was seen in the group treated with steroid and antibiotics than antibiotics only.
  • ―特にその心音図経過の観察―
    小沢 正博, 土肥 寿夫
    1966 年 26 巻 9 号 p. 543-549
    発行日: 1966/09/28
    公開日: 2010/09/09
    ジャーナル フリー
    It has been accepted genrally that three fourth of patients with chorea minor were proceeded by rheumatic fever. In such a case, it is seldom that patient appears to be seen with physical findings of chorea minor more dominant than rheumatic fever because of apparent findings.
    It is the purpose of this paper to present 2 cases of patients with the chief complaints considering chorea minor, discovering the carditis and were followed phonocardiographically.
    These 11 and 6 years old females were seen in our clinic because of incoordination of the extremities, emotional instablility and/or speech desturbance. The first case was noticed to have carditis upon first visit, while the latter to have carditis by the follow-up study.
    Clinical findings, phonocardiographic examination and other laboratory studies revealed the diagnosis of rheumatic fever in these two patients.
    The phonocardiographic studies were performed weekly in these cases employing a “Multifilter system phonocardiograph”. The recordings were made in a supine position at the end of expiration on the apex, pulmonic, aortic and Erb's area. Also, the recordings were made during normal respiration on the pulmonic area to examine the (respiratory) splitting of second heart sound.
    The specific features were as follows : pan-systolic decrescend murmur, mid diastolic murmur in acute stage, galloping rhythm of apical area and relatively fixed splitting of pulmonic second sound. Effective results were obtained by the treatment of glucocorticosteroid in both cases.
  • 藤沢 竜一, 金子 和義, 高場 利博, 中田 幸之介, 岡部 伸弥, 藤井 浩一, 唐沢 弘文, 森本 和大, 石井 淳一, 小河原 当元 ...
    1966 年 26 巻 9 号 p. 550-555
    発行日: 1966/09/28
    公開日: 2010/09/09
    ジャーナル フリー
  • 菱田 豊彦
    1966 年 26 巻 9 号 p. 556-559
    発行日: 1966/09/28
    公開日: 2010/09/09
    ジャーナル フリー
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