In his preceding paper, the author stated that chick erythrocytes agglutination of mumps virus was inhibited considerably by human mother blood serum and human umbilical cord blood serum, and that the inhibitory action of the former was much stronger than that of the latter. The titres of chick erythrocytes agglutination were lowered to the same level by the action of crude culture filtrate of V. cholerae (R. D. E. by Burnet and others), but were not so much affected by heating at 60°C for 20 minutes. The complement fixing antibody in these sera seemed not to exist. At least, no definitely positive result were obtained.
In view of the above findings, it was considered that the so-called non-specific inhibitor was abundantly contained in the mother blood sera.
Further, the residuall inhibitor after R. D. E, treatment was also discussed.
The hemagglutination inhibition titre of human and experimental animal sera were found lowered by the R. D. E. treatment, but the residual inhibitory action was simultaneously noted to certain extent in almost all sera. But, when these sera were mixed with rabbit mumps virus immune serum, the effect of the R. D. E. treatment was not recognized in most cases. Since the so-called hemagglutination inhibitory antibody was least affected by the R. D. E. treatment as was in the case of influenza virus, the author was led to believe that the residual inhibitory titre of human serum is a natural antibody. However, the author failed to believe immediately that the residual inhibitory titre of animal serum is an antibody.
Criticizing the above facts, it was not necessarily easy to learn without further study that the human residual inhibitor means. It seemed very difficult for the author to regard the human residual inhibitory titre as the genuin hemagglutination inhibitory antibody unlesss the inhibitor in the non-mumps serum was completely destroyed by the R. D. E, treatment.
The experimental data on the control tests relative to the hemagglutination inhibition by mother and umbilical cord blood sera are scheduled to be published at a latet date.

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Wistar albino female rats were poisoned by intraperitoneal administration of 50 mg/kg lead acetate after 48 hours' starvation, and they were hematologically observed to obtain the following results.
1) The hemoglobin concentration in the animals which were held under 48 hours' fasting remarkably fell by the administration of lead acetate, and its recovery of the normal level required an extremely long period of time.
2) The increase in the circulating reticulocytes after the administration of lead was. manifested later in the fasting animals.
3) The eisinopenic response due to the administration of lead acetate was significantly marked in the fasting animals.
Consequently, it could be concluded that starvation promoted the stressor effect of lead acetate, and inhibited the recovery from lead poisoning.

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“Dots counting” tests were given to high school boys and girls before and after physical exercise and terminal examination. There recognized a marked effect of training on the time required for counting in this test, but it was shortened even by only one, experience.
After the terminal examination, errors of counting showed a tendency to overcounting, and this was probably due to mental tension.
After physical exercise, errors in counting showed a tendency to miss-counting, but., the time required for counting was remarkably shortened.

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Three healthy adults were exposed to high temperature (38°C, 40°C and 43°C) and high humidity (60%) environment for 90 minutes 3 times at 3 or 4 days' intervals in winter. The number of circulating eosinophils and 17-ketosteroid excretion in the urine were determined before, during and after each heat load. The following results were thus obtained.
1) Due to exposure to each heat load, circulating eosinophil count was found decreased without any connection with heat level, but, after repeated exposures, an increase in the basal level of circulating eosinophils was observed.
2) After repeated exposures to heat, an increase in the excretion of 17-ketosteroid during exposure to heat was noted, but a decrease in the total amounts of 24 hours' excretion was recognized with repetition of exposure to heat.
3) After each exposure to heat stress, a marked increase in the hemoglobin concentration was noted, but the basal level was found lowered with repetition of exposure to heat.
In view of the above, it may be concluded that pituitary adrenocortical function has been altered through exposures to heat stress, and that this alteration is connected with the acclimatization to such high temperature-humidity environment.

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Sodium citrate has been in use to remove lead or redioactive elements from bones. The process of effects of sodium citrate injection is assumed as the co-deposition of sodium citrate with bone salts on the surfaces of apatite crystal and depolymerization and dissolution of glycoprotein ground substance of bone.
Administration of sodium citrate in rats led to a rise of bone citrate. However, no significant changes was observed in mucoprotein content of bone and serum in rats treated with sodium citrate as compared with rats injected with physiological sodium chloride solution. These facts would indicate that the effects of sodium citrate on the mobilization of foreign substance deposited in bones are due primarily to its ability to form complexes with rations, but not due to the depolymerization and dissolution of glycoprotein matrix.

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The case is a 37 years old male. Under the suspicion of rectal carcinoma, biopsy was taken. The examinations on this biopsy revealed the presence of lymphocytes, eosinophils, reticulocytes, marked fibrosis and formation of lymph-follicles centering in the submucosa tissue, suggesting so-called Crohn's disease. Otherwise, no picture of carcinomatization was recognized. The case was clearly proved to be rectal carcinoma. Histologically, in addition to the above findings, carcinomatized mucosa and mucosa partly substituted by carcinomatous cells were recognized. In view of the above findings, the case was considered to be a case of rectal carcinoma, which was induced by the preceding of Crohn's disease of rectum. Though any definite conclusion cannot be drawn due to lack of serial biopsies, the case should be regarded as a note-worthy case.

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Up to the present, no definite conceptions were ever be given as to the difinition, classification or so-called lung cyst and especially its relation to bronchiectasia. The present authors investigated an operatively cured case placing the emphasis on its relation to bronchiectasia. Thus, the authors proved that the so-called lung cyst is nothing by the dystic bronchiectasia. The classification is : —
I. Bronchial lung cyst (including so-called cystic bronchiectasia and honey comb lung)
II. Bronchial alveolar lung cyst
III. Alveolar lung cyst
The authors considered it proper that a word like Blebs, Bulla or Pneumatocele indicating its originating tissue be placed before lung cyst, and that each of them should be further divided into “prenatal prenatal and postnatal” and “solitary and multiple” to give easily understandable classification.

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In the present paper, the authors briefly reported a case which became fatal due to post-operative cardiac loading induced by the hypertrophy and dilatation of right heart following the primary sclerosis of pulmonary artery described by Brenner and thrombosis of nulmonarv artery.
The authors also reported a case of typical post-operative embolism of pulmonary artery.

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Strains of mutabile type variants (Murase) were obtained from each of the original strain and its lactose fermenting variant of B. coli mutabile Massini. Though the pattern of the appearance of the variants were different according to the respective strains, but between the original and its variant strains, the patterns were coinciding.
Now this M type, MT (Murase) type and galactose formenting daughter type RT (Fukutome, and others) were obtained and were comparatively examined for their behaviors toward lactose and galactose. The results were as follows.
MT produced lactose fermenting variant in it, thus, it fermented lactose later as it is transformed into a para-coli strain. The RT produced from M type fermented galactose, and became a typical Massini type B. coli, which produces characteristic daughter type variants only on Endo's agar plate. On the other hand, the lactose fermenting variant 'from the original strain (VMT) was found fermenting lactose within as 24 hours, and later in most cases, made the medium alkaline. In addition, the RT produced from M type strain was found to be strongly lactose fermenting as the initial variant (V) was, and further it was galactose fermenting offering a difficulty to distinguish one from the ocher. The lactose fermenting strain (OMT-V) produced from the MT of the original strain showed the same behavior in the lactose fermentation as that of the MT of the variant strain (VMT) making one indistinguishable from the other. However, either of them were galactose non-fermentors suggesting that they were so-called MT. The above findings indicated that the behavior of M type toward lactose showed a strong tendency to coincide with that of the type from which the M type had been produced, though varying in degrees. Furthermore, when viewed from the behavior toward lactose, and others, the RT appeared as if it had returned to the type from which the M type was directly produced.

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Having bronchial epithelium theory and alveolar epithelium theory, opinions of various workers on the above subject has yet not come to the conclusion. The author conducted various investigations on the lung tumors induced in mice by the oral administration of 0.1% urethane. The following results were thus obtained.
(1) The greatest majority of the cases (102 out of 105 tumors) was alveolar epithelial. Nevertheless, though small in number (3 out of 105 tumors), bronchial apithelial tumors were definitely recognized.
(2) The existing theory that the tumors frequently induced subpleurally is the result of superficial observations. Actually, no significant difference was recognized between the two.
(3) Inflammation and atelectasis showed no particular causative relations with the formation of the tumors.
(4) As far as the experimental results over a period of 28 weeks, no malignant tumors have not yet discovered.

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In the present work, injection of aqueous solution of nicotine and solution of olive oil were given to mice subcutaneously to investigate histopathologically the toxicity of these solution on the liver.
When injections of nicotine solution exceeding 3.0 mg were given, general clonic convulsion was observed, thus deaths were caused among the animals of 3.0 mg group, 5.0 mg group and 7.0 mg groups at the rate of 10%, 25% and 20% respetively. These rates were higher than that treated with olive oil. As the histopathological changes in the liver, swelling, granular degeneration, vacuolar degeneration and nuclear degeneration of the liver cells were observed. The degree of these pathological changes was found mild up to the dosis of 3.0 mg, but it was found strong when the dosis was raised to 5.0 mg or 7.0 mg in every instance.
The vacuolar degeneration of the liver cells were observed not infrequently in combination with the granular degeneration. Only in the case with 3.0 mg nicotine oil solution, this change was noted at the rate of 48%, but in all other cases, the rate was 80-100% showing no parallelism with the increase in the dosis of nicotine.
Both of the granular and vacuolar degenerations of liver cells observed in the present experiments were understood as the morphological indication to the organ due to tissue intoxication induced by nicotine, and the vacuolar degeneration was considered the morphological picture of the edematous changes due to the obstruction in the water metabolism of the tissue cells.
The fact, that the accumulation of nicotine in the mice which were consecutively administered with nicotine was not so marked, was considered to be due to the fairly rapid excretion of nicotine by the mice, unlike the case of the formation of marked dermal edema of chick embryo, which posesses a specific excretory mechanism.
Both of the granular and vacuolar degenerations of the liver cells was considered a tissue intoxication, secondarily induced intoxication, which is belonging to secondary direct type.

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Remarkable advances and developments of the chemotherapeutic preparations were made in recent years. Simultaneously, reports on their side reactions are also beingg published quite frequently.
In the present paper, the author investigated histopathologically the influences of the single or combined administrations of INAH and Tibione on the kidney of mice.
In the cases of single administrations of INAH, an oral dosis of 10 mg/kg, subcutaneous doses of 10 mg/kg, 60 mg/kg and 100 mg/kg were given. In the cases of the single administration of Tibione, both oral and subcutaneous doses of 0.5 mg/kg, 1.0 mg/kg, 2.5 mg/kg and 5.0 mg/kg were given. In the cases of combined subcutaneous administrations, all combinations were given, and in the cases of combined oral administrations, only combinations, of 10 mg/kg of INAH and varying doses of Tibione were given. Administrations of drugs were conducted daily for 30 days, and the animals were observed for 1 week thereafter without administration before they were sacrificed.
In the cases of single subcutaneous injections of 10 mg/kg, 60 mg/kg and 100 mg/kg of INAH, granular degeneration, vacuolar degeneration, desquamation, defects, dissociation and necrosis of the epithelial cells of the urinal tubuli of mice were observed. The degree of these pathological changes became greater in parallel with the increment in the dosis. The degree of the granular degeneration, vacuolar degeneration etc. of the epithelial cells of the urinal tubuli observed in the cases of Tibione, was not found to be proportional to the doses when administered orally. However, when administered subcutaneously, the degree of these changes formed a curve indicating gradual increase with the highest point at 5.0 mg/kg dose.
In the cases of combined INAH-Tibione subcutaneous administrations, the regressive changes in the epithelial cells of the urinal tubuli were found roughly in proportion to the doses of Tibione combined. The granular degeneration in the epithelial cells of the urinal tubuli was considered to be based on the tissue intoxication mechanism, consequently was considered to correspond to the secondary direct type.
The vacuola degeneration was also considered to be originated from the tissue intoxication, and further to the development tc the edema formation mechanism, consequently was considered to be related to the edematous changes of the interstitium. In view of the above, this was considered to be corresponding to the secondary indirect type. Consequently, the author considered that the changes in the kidney of secondary direct and secondary indirect types were co-existing side by side in the present experiments.

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1) The first case is a 40 years old male. The case was suffering from a fistula of the eye-lid originated from left frontal sinusitis. The case was also suffering from pyocele of frontal sinus accompanied by ectropion.
The second case is a 47 years old female. This case was suffering from orbital phlegmone due to left frontal sinusitis. In both of the above cases, no subjective nasal symptoms were recognized. In this paper, the author stressed the necessity of the cooperation between ophthalmologist and oto-rhino-laryngologist in the treatment of such cases as above.

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