Ethyl alcohol (EA) and Methyl alcohol (MA) were administered intravenously into rabbits in two different doses of large (2.0 cc/kg for EA and 0.2 cc/kg for MA) and small (0.2 cc/kg for EA and 0.02 cc/kg for MA) every 4 days for a period of a month for the observation of their antibody productivity against soluble antigen (human serum), corporal antigen (0 type human erythrocytes) and lipoid antigen as well as the changes produced in their body weight, blood picture and visceral organs. The results obtained are summarized in the following.
A.
Antibody productivity 1. Against soluble against antigen: Production of immune precipitin was markedly reduced by the administration of EA regardless to the size of injection. While, in the case of MA, the reduction was moderate and likewise the former case no difference was observed by the difference in the size of injection.
2. Against corporal antigen : Rabbits on EA small dose injection responded with a marked production of immune agglutinin against the final injection of antigen, but its production was extremely low in the case of large dose injection. In rabbits on MA injection, on the other hand, the production of immune agglutinin was enhanced slightly when small dose was used. They showed no difference from the control animal, however, when large dose injection was used.
3. Against lipoid antigen : Production of lipoid antibody showed no change in comparison with control when EA was used in small dose, but it was markedly reduced when the dosage was large. In the case of MA, the production of lipoid antibody was extremely poor regardless to the size of injection.
B.
Changes in the body weight Small dose injection of EA was responded with a slight increase in the body weight, but there was a remarkable decrease when the dosage was large. In the case of MA, the body weight was reduced regardless to the size of injection. In this case, however, the body weight was restored normal by the end of the experiment.
C.
Changes in the blood picture 1. In the case of EA, erythrocytes, leucocytes and hemoglobin reduced regardless to the size of injection.
2. With MA, erythrocytes reduced by small dose injection, while they remained unchanged by large dose injection. Leucocytes remained practically unchanged by small dose injection and reduced by large dose injection. Hemoglobin reduced in either case of small dose or large dose injection.
D.
Changes in visceral organs Liver : Atrophy of the tissues and striking decrease of glycogen were observed in either case of EA or MA regardless to the size of injection. By the preliminary treatment with EA small dose, dilatation of Disse's space and fibrinoid degeneration of the wall of central veins became fairly remarkable. While, in the case of MA small dose, moderately strong cellular infiltration, slight separation of serum and swelling of Kupffer's stellate cells were observed.
Spleen : In either case of EA or MA, regardless to the size of injection, the splenic pulp was found to have dilated. In both cases of EA and MA, when the dosage was small, anemia and dilatation of the splenic sinuses were recognized. Slight increase of reticular cells was seen when MA was used in large dose.
Kidney : In either cese of EA or MA, regardless to the dose of injection, the changes observed in the kidney were the pronounced hyperemia, fibrinoid degeneration of the vascular wall and interstitium, degeneration and necrosis of urinf erous tubules and the stagnation of the blood in glomeruli. When EA was used in small dose, there were also marked separation of serum and agglutination of the blood cells.
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