昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
35 巻, 3 号
選択された号の論文の9件中1~9を表示しています
  • 上條 一也, 庄 貞行, 安原 一
    1975 年 35 巻 3 号 p. 179-185
    発行日: 1975/06/28
    公開日: 2010/09/09
    ジャーナル フリー
  • 崔 二條
    1975 年 35 巻 3 号 p. 187-201
    発行日: 1975/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    当教室既往の胎生期の薬理学的研究に鑑み, 有精鶏卵にSulfathiazole (ST) とこれにフタル酸のついたPhthalylsulfathiazole (Ph-ST) を負荷して両者の鶏胎仔に及ぼす影響を比較検討した.次でフタル酸とそのエステル類6種についても同様検索した.結果は次の通りである.
    1.STならびにPh-ST共に負荷量が大きい程鶏胎仔の発育は劣つてくる.STの高濃度負荷例には長管骨形成不全その他による短脚 (59.4%) をはじめ水症, 嘴の異常, 矮小等が発生したが, Ph-ST負荷例には骨の異常は認められなかつた.Ph-ST例の尿のう水中ST排泄はST例のそれに比し著しく少い.以上のことはPh-STの卵白内から胎仔への移行がきわめて少いためと考えられる.
    2.フタル酸とそのエステル即ちDimethyl-, Diethyl-, Dibuty1-, Diisobuty1-, Dibutoxyethyl-並びにDioctyl phthalateの内, 鶏胎仔に対し毒性が最も強いのはDiethyl phthalateで, 次でDime-thylphthalateである.孵卵18日目においては胎仔体重はいずれも対照に劣らないが, 殆どのグループに発育異常ないし奇形が認められ, 嘴異常が最も多い.この発生率と薬物負荷量の間には一定の関係は認められない.
  • 鏡 勲
    1975 年 35 巻 3 号 p. 203-209
    発行日: 1975/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    When the controlled ventilation was performed with the aid of the mechanical ventilator connected to the anesthesia machine under general anesthesia according to the calculated respiratory condition to keep the arterial Pco2 to the predicted value, arterial Pco2 sometimes showed lower value than expected.
    We examined this discrepancy and the results were as followes.
    1) Resperatory volume indicated on the ventilator was inaccurate. Mostely, this volume was smaller than the actual volume which came out from the ventilator.
    2) Changes in the fresh anesthetic gaseous flow into the circle of the anesthesia machine also altered the resperatory volume.
    3) Therefore, respiratory condition has to be set up not on the ventilator but on the patient himself.
  • 今村 一男, 近藤 常郎
    1975 年 35 巻 3 号 p. 211-214
    発行日: 1975/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    The β-Glucuronidase in serum, urine and tissue from patients of various diseases was studied by means of the technique of starch zone electrophoresis.
    The following results were obtained.
    1. The electrophoretic patterns of β-Glucuronidase in the tissue of prostatic cancer, bladder cancer and renal carcinoma showed the highest activity at the second peak. Air the patterns were similar.
    2. The electrophoretic patterns of β-Glucuronidase in the tissue of testicular tumor (seminoma) was most active at the third peak. At the same time it suggested that seminoma would be benign rather than malignant.
    3. In sera, β-Glucuronidase activity was very low in all peaks of the electrophoretic patterns in all specimens. On the contrary, the patterns of the urine ran parallel to those of the tissue.
    4. The existence of isozvme of β-Glucuronidase was positive.
  • 桑門 皓
    1975 年 35 巻 3 号 p. 215-222
    発行日: 1975/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Postmortem coronary angiography was performed in 132 autopsy cases from May in 1970 to June in 1973, and coronary sclerosis was discussed pathomorphologically. Calcified deposits in the coronary artery were observed in 53 cases out of them. Calified deposition was seen in 22 cases out of 31 myocardial infarction cases.
    1. In 53 % out of the cases above mentioned, calcified deposits were identified in the three main coronary branches.
    2. Calcified deposits were also identified in 73 % out of 22 cases of myocardial infarction in the three main coronary branches.
    3. In all cases of myocardial infarction accompanying calcified deposition in the coronary artery, the left anterior descending coronary artery revealed also calcified deposits.
    4. On the anastomosis between left and right coronary artery, there were 88% of coronary anastomosis from right to left, and 52% from left to right.
    5. Complete occulusion of coronary artery was observed in 8% of cases of myocardial infarction cases. There were stenosis of coronary artery over 75% degree in all cases of myocardial infaction.
  • 安藤 弘
    1975 年 35 巻 3 号 p. 223-233
    発行日: 1975/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Immunological effects of D-penicillamine were studied in the rabbits sensitized 2 times weekly for 2 weeks with BSA-anti BSA rabbit serum complex. Rabbits were divided into. five groups according to doses of D-penicillamine (D-P) and time of administration. The sections of the popliteal and axillary lymph nodes were double-stained using specific antise-rums (FITC-anti IgM and Rhodamin-anti-IgG) . RFLS producing cells were studied by FITC labeled heat-aggregated human IgG. There was little change in the ratio of the number of fluorescein-positive cells IgM/IgG in the group without administration of D-P (the control group) during the periods of 1, 2 and 3 weeks. The ratio of IgM to IgG cells was slightly increased during the first week and remarkably increased during the second week in the group with continuous administration of D-P for 1 week before sensitization (II group) and the group with simultaneous administration for 1 week with the first sensitization (III group) . The most marked increase was observed in the group with continuous administration for 3 weeks from 1 week before sensitization till 2 weeks after it (V group) and there was a rema-rkable increase, especially in IgM producing cells. Anyhow, the ratio of IgM to IgG was increased by administration of D-P, and the IgG producing cells were mostly decreased. RFLS producing cells in the lymph nodes were increased in groups II and III as well as those in the control group. However, there was a remarkable decrease in group V with time, which showed the contrary variation of IgM/IgG. In the relationship between RFLS producing cells in the lymph nodes and RFLS titer in the blood, all negative cases in the former also showed negative in the latter. There was no relationship between the number RFLS cells in the lymph nodes, and the RFLS titer in the serum.
  • 電気生理学的研究
    西堀 実
    1975 年 35 巻 3 号 p. 235-245
    発行日: 1975/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    With a view to examining how far the regeneration of peripheral nerves is affected by their being juvenile or aged, male rabbits (aged and juvenile ones weighing approximately 2, 500 gm. and 700 gr. respectively) were subjected to severance with a sharp knife of the tibial nerve in the left thigh, immediately followed by atraumtic suture of the nerve, to study the variation in the action potential of the nerve at its periphery from the 1st until the 40th week after the surgery. The results obtained are as follows:
    1. The peripheral nerve was regenerated at an average rate of 2.14 mm a day in aged animals and 2.56 mm in young ones, with a difference of 0.42 mm in favor of the latter group.
    2. In the aged group the action potential of the regenerated nerve was recovered up to 40-80 % of the average level for untreated normal group. In the juvenile group a recovery up to 10-80 % of the average level for untreated normal group was attained in 5 to 10 weeks and the subsequent course was the same as in the aged group. The action potential of the regenerated nerve was elevated both more rapidly and to a closer level to that for untreated normal group in juvenile that the aged group.
    3. In the juvenile group the velocity of conduction through the regenerated nerve was recovered up to 80 % of the average normal value in a shorter period than in the aged group: in 7-10 weeks in the former group as compared with 9-12 weeks in the latter.
    4. Both bed-sore and muscle atrophy of the legs on the examined side were more liable to develop in the aged than the juvenile group. There was necrosis of the foot due to circulatory disturbance etc. in the former group but not in the latter
    5. There was generally more satisfactory functional recovery after regeneraton of juvenile than aged nerves, presumably because juvenile nerve fibers can regenerate more vigorously with a greater daily increment in their length and also are less distant in absolute terms from the end organ than aged fibers.
  • 佐野 新, 石橋 守正, 高野 憲一郎, 草ケ谷 雅志, 安達 浩行, 斉藤 博文, 鶴岡 延熹, 石井 善一郎, 長谷川 淵, 田島 洋, ...
    1975 年 35 巻 3 号 p. 247-253
    発行日: 1975/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    A 57 year old man. Hepatosplenomegaly was found on routine physical examination and he was admitted on October 26, 1971.
    The liver was palpable two fingerbreadths below the right costal margin. The spleen was extended three fingerbreadths below the navel.
    Peripheral blood showed normochromic anemia and leucoerythroblastosis. So called tear drop cells were seen in blood smear. Ph1chromosome was negative.
    Alkaline phosphatase score of neutrophils was normal level.
    Biochemical examination revealed hypogammaglobulinemia, particularly IgG was decreased.
    Ferrokinetics study showed delayed plasma iron disappearance rate and the failure of red cell utilization.
    Bone marrow aspiration was difficult. Fibrosis was found by surgical biopsy.
    Testosterone propionate and prednisolone were ineffective. Because of increased anemia, frequent transfusions were nescessary. On the course of admission, ascites was seen occa-sionally. He died of lung tuberculosis on August, 28, 1972.
    At postmortemn examination, there was generalized fibrosis of the bone marrow. Tuberculosis was recognized in the lung, liver and lymphnodes.
  • 今村 一男, 菅 孝幸, 藤巻 悦夫, 門馬 満, 高 国子, 伊東 昇太, 西尾 友三郎, 村田 憲彦, 阿万 修二, 江頭 亨, 庄 貞 ...
    1975 年 35 巻 3 号 p. 255-259
    発行日: 1975/06/28
    公開日: 2010/09/09
    ジャーナル フリー
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