昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
21 巻, 4 号
選択された号の論文の10件中1~10を表示しています
  • 漆原 春樹
    1961 年 21 巻 4 号 p. 327-355
    発行日: 1961/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    The concept of gastric ulcerocancer has already been established by Hauser. The author's colleagus Nakamura tried to expand the criteria of this ulcerocancer. He could select 126 cases of ulcerocancer out of the 512 cases of gastric cancer received excision during the past 7 years in the Second Department of Surgery, Tokyo University School of Medicine.
    This author undertook the clinical investigation of these 126 cases of ulcerocancer and statistic observations were made on their symptoms and prognosis. As controls, clinical findings of the 60 cases of round ulcer and 100 cases of non-ulcerative cancer were employed for comparison. The results obtained were as follows :
    1. Male and female ratio of ulcerocancer was 2.5 : 1. Patients at the age of fifties were predominant. But there were a number of cases developed in relatively young age groups. Period of suffering was intermediate between gastric ulcer and gastric cancer.
    2. As for the clinical symptoms from the time of onset to that of operation, most of the patients suffered from epigastric pain in an early stage gradually developing the symptoms of stenosis. Namely, at the time of onset, the symptoms of ulcerocancer resemble to the symptoms of gastric ulcer and when advanced, necessitating surgical operation, they become nearly the same as the symptoms of gastric cancer.
    3. In an early stage, most of the patients showed the hyperacidity of gastric juice, but when advanced they showed hypoacidity.
    4. In an early stage, diagnosis by X-ray is highly difficult. In contrast to the high rate of the detection of nische, some cases are deficient of the shadow and, moreover, the rate of palpable tumor is low at the time of fluoroscopy leading to the erronious diagnosis of gastric ulcer.
    5. The site of predirection is the pyloric region and the lesser curvature. In most cases, , they are less than 5 cm in diameter. Spread to the surrounding organs at the time of operation was recognized in 55% and swelling of the regional lymphnodes was recognized in 76%.
    6. As for macroscopical classification, 23% were Borrmann's type II and 77% were type III. Histologically, 61% were adenocarcinoma and 39% were solid cancer. Type C of C, P, L classification was small in number. Advanced cases of types P and L were also few.
    7. As prognosis of the patients received surgical operation, the survival rate for 3 years was 42% and for 5 years 32%.
    8. C, P, L classification agreed well with the prognosis of surgical operation.
    9. Nakamura's classification of I, II and III based on the intensity of cancerous infiltration in the periphery and at the base of the ulcerative cancer also agreed well with the prognosis of the patients.
  • 谷江 澄子
    1961 年 21 巻 4 号 p. 356-373
    発行日: 1961/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    A number of opinions have appeared and still under dispute on the etiological factors of bronchial asthma. Detailed inquiries were made by the use of the questionaire card together with clinical observations by the help of various laboratory tests. Results of those studies confirmed the statement of Rackemann that most of the young patients belong to the asthma of external causes while those of the middle age or old belong to the asthma of internal causes. Presence of allergen, however, was suspected even among the patients of the latter group not to speak of the former, and especially the importance of house dust as allergen.
    In this connection, with an intention of clarifying the significance of house dust as asthmatic allergen, observations were made on the dermal reactions and the leucolytic phenomenon elicited by the house dust extract as well as on the clinical effect of desensitization treatment.
    Positive reactions to the house dust extract were discovered in a high percentage among the asthmatic group with an evident difference from the control group. Leucolytic phenomenon by the house dust extract too was recognized in a larger number of the patients in asthmatic group than the control. The therapeutic effect of desensitization treatment was quite favourable and the presence of the heat stable blocking antibody was demonstrated in the sera of the patients under this treatment (in 5 out of the 13 cases) .
    In view of the findings stated above, it is considered that there are a considerable number of the asthmatic patients due to the house dust and that specific desensitization treatment should first be attempted.
  • 岡田 広
    1961 年 21 巻 4 号 p. 374-381
    発行日: 1961/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    1. Loading of Vanillin in a small dose gives no evident influence on the development of chick embryos, while its administration in a large dose shows some growth inhibition from the 15 th day of incubation.
    2. Vanillin gives no evident influence on the amount of the allantoic fluid of embryos.
    3. Nitrogen content of the allantoic fluid of control eggs shows a remarkable increase on the 12 th day of incubation in contrast to that on the 9 th day and it shows a still more remarkable increase on the 15 th day, while a marked decrease is observed on the 18 th day following the reduce in the amount of the allantoic fluid itself.
    Eggs of Vanillin loading show exactly the same changes in the nitrogen content of the allantoic fluid.
    4. Loading of Piperonal in a small dose gives a slight growth promoting effect and even its administration in a large dose shows no appreciable growth inhibition.
    5. No malformation of embryos is recognized by the loading of Vanillin and Piperonal.
    6. The amount of Adrenaline in the adrenal of embryos shows an increase following the advance in the days of incubation.
    Loading of Vanillin gives no appreciable influence on the amount of this Adrenaline except that it causes a slight increase on the 15 th to the 18 th day of incubation in contrast to the control.
    7. Loading of Piperonal, however, shows an evident increase in the amount of Adrenaline in the adrenal of chick embryos and this tendency becomes stronger when a larger dose is loaded.
  • 高田 一
    1961 年 21 巻 4 号 p. 382-403
    発行日: 1961/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    Employing a total of 64 rabbits, tubed pedicles of the same size (10 × 5 cm) were made on the dorsal surface of both left and right by the method of Davis and Kitlowski. Tubed pedicles on the right side received Histamin iontophoresis, injection of Histamin solution, Trazolin preparation (Imidain), Kalikrein, protein assimilating hormone Norandrostenoron phenylpropyonate (Durabolin), general aminoacid preparation (Moriamin), application of Hirudoid ointment, or the iraadiation of radiothermy. Separately, as controls, tubed pedicles were made in the same manner and the right side pedicles received the injection of mere physiological saline in one group, daily massage for 10 minutes in another group and no treatment in the third group. Animals were sacrificed by sending air through the ear vein and after thoracotomy a contrast medium (50-60 cc of Hypec or 76% Urographin) was sent into the pedicle throgh the aorta descendens for vascography. In addition, parrafin and corrosion samples were prepared from a part of the tubed pedicle for the observation of the vascular augmentation in each tubed pedicle. Stated in the following are the results obtained thereof :
    1. When Histamin iontophoresis was applid the most remarkable vascular augmentation was observed, Injection of protein assimilating hormone Durabolin, Kallikrein and the applicatiod of Hirudoid ointment which showed also relatively remarkable augmentation.
    2. In the animals received the injection of protein assimlating hormone (Durabolin) and Kallikrein, some vascular augmentation was observed on the tubed pedicle of the side without injection which is considered to by due to the systemic effect of hormonal preparations. It appears, however, these preparations have some direct topical effect aside from the systemic one as there was recognized still more remarkable vascular augmentation on the tubed pedicle of the side received injection.
    3. Tubed pedicles prepared after application of Histamin iontophoresis as preliminary treatment also showed some vascular augmentation but it was of very mild one.
    4. Contrary to the author's expectation, animals received the injection of Histamin solution, Trazolin preparation (Imidalin), general aminoacid preparation (Moriamin) and the irradiation of radiothermy showed virtually no vascular augmentation on their vascograms nor in their histological findings. It is too early, howeve, to draw any conclusions from these results on account of the experimental conditions such as the period of experiment employed in the present stuy.
    5. It is difficult to expect the same clinical effects on human beings because of a considerable difference in the construction of skin between rabbits and human beings, for and instance, rabbits do not possess sweat glands. But the results mentioned above may be considered to show the general tendency of respective treatment.
    6. Accordingly, the results of present study are considered to offer a number of interesting problems as to the clinical application of Histamin iontophoresis, protein assimilating hormone injection (Durabolin), Kallikrein injection and the application of Hirudoid ointment to the skin grafting.
  • 満岡 実夫
    1961 年 21 巻 4 号 p. 404-414
    発行日: 1961/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    A protein fraction with fibrinolytic activity and a white globulin substance without this activity obtained by its treatment with vitamin C were separated from the canine plasma diluted 10 times with distilled water and precipitated at pH 5.9 by the addition of acetic acid. Separately, Caeruloplasmin, copper combining glycoprotein was separated from the porcine plasma. These substances were administered on rabbits and histopathological investigations were made on their spleen. The results obtained were as follows :
    1. Rabbits received the administration of the protein fraction with fibrinolytic activity presented a picture of hemolytic anemia and later a picture of the hypoplasia in the bone marrow. While, the spleen showed in many cases congestion, dilatation of the sinus, swelling of small lymphnodes, deposition of hemosiderine, hypertrophy and hyperplasia of reticulocytes just as those seen in the case of acquired hemolytic anemia, phagocytosis of erythrocytes by hypertrophied cells and thee hyperplasia of the endothelial cells of the sinus. However, extramedullary hematopoiesis was not recognized.
    2. Rabbits received the administration of the vitamin C treated white globulin substance did not show the picture of hemolytic anemia. In the bone marrow, they showed a picture of hyperplasia, while in the spleen no remarkable change was recognized in the lymphatic folicles, sinus etc. Only in emaciated cases, extramedullary hematopoiesis was recognized.
    3. Rabbits received the administration of caeruloplasmin showed the proliferation of erythroblasts in the bone marrow when it was in the reduced form and the proliferation of the young granulocytes when it was in the oxidized form but extramedullary hematopoiesis was not recognized. They were free from the follicular hypertrophy, dilatation of the sinus and also from the picture of hemorrhage and necrosis. Only in a few cases, mild deposition of hemosiderine and the phagocytosis of erythrocytes by reticulocytes were recognized.
    4. Animals received the vitamin C treated substance were either free from hemosiderine deposition or if present, it was of mild one.
  • 定方 恭一
    1961 年 21 巻 4 号 p. 415-437
    発行日: 1961/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    Stripping of the horny layer and the epidermis was given on the skin of both rabbits and human beings and skin samples were collected with certain definite intervals for a period of 30 days in order to investigate the changes produced in the contents of SH-group, SS-group, nucleic acids aed succinic dehydrogenase employing the direct (d-) and indirect (i-) methods of nitroprusside reaction (N. P.), DDD method (Barrnett-Seligman), Bennett method, nucleic acid staining and neotetrazolium method (NT) . Stated in the following are the results obtained thereof :
    1. Processes of the traumatic healing were divided into the following 6 stages by the characteristic changes observed on the contents of the substances stated above.
    Stage I : For 3 hours after stripping (so-called shock stage), various staining reactions remain either unchanged or weakened.
    Stage II : From 3 hours after stripping to 12 hours (hypertrophy stage of the basal and the prickle cells), sudden increase in SH-group and the increase in ribonucleic acid and succinic dehydrogenase in the latter half of this stage by d-N. P, method.
    Stage III : From 12 hours after stripping to 5-7 days (stage of cell division), SH-group and ribonucleic acid show the strongest colour reaction by d-N. P, method.
    Stage IV : From 5-7 days after stripping to 20 days (stage beginning the formation of horny layer), SH-group, succinic acid dehydrogenase and desoxyribonucleic acid show the strongest colour reaction by Bennett method, and SH-group and SS-group show the strongest colour reaction by DDD method in the latter half of this stage.
    Stage V : From 20 days after stripping to 30 days (stage of the formation of horny layer and the proliferation of epidermis), SH-group by i-N. P, method and SS-group by DDD method show the strongest colour reaction.
    Stage VI : Later than 30 days after stripping (convalescent stage), all colour reactions are restored to normal.
    2. Accordingly, it is considered that the increase in SH-group by d-N. P. method indicates the preventive reaction and the same by i-N. P. and DDD methods is related to the cornification, while the increase in SS-group by DDD method suggests the formation of horny layer.
  • 大滝 梓
    1961 年 21 巻 4 号 p. 438-446
    発行日: 1961/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    With an intention of knowing the specific characters of gastroptosis, comparisons were made between the patients of gastroptosis and non-gastroptosis emphasizing the findings of gastrocamera. Stated in the following are the results obtained thereof :
    1. Presence of gastritis was recognized on the picture taken by gastrocamera in 96% of gastroptosis patients examined, and 83% were atrophic gastritis showing a larger number of the appearance of atrophic gastritis than in the patients of non-gastroptosis.
    2. On comparison with the patients of non-gastroptosis by the difference in the kind of gastritis, many of the patients of gastroptosis complained of the heavy feeling in stomach and the presence of atrophic changes was high. Namely, the complaints of gastroptosis patients are not simply the complaint of gastritis but they have an additional complaint of gastroptosis itself.
    3. Examination only by X-ray showed an extremely high rate of escaping the detection of ulcer among the patients of gastroptosis.
  • 吉崎 千代子
    1961 年 21 巻 4 号 p. 447-457
    発行日: 1961/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    Each of the original, M, WRT and RT variants of the test organism was inoculated into either one of the physiological or dilute phosphate buffer solution containing galactose and BTB or BCP, and the changes produced in pH were followed by repeated observation. At the same time, galactose consumption was determined availing Somogyi's method. And, thus, the investigations were made on the shifting of galactose fermentability accompanying so-called circulatory variation of O → M→ RT. Results obtained were as follows :
    M and MT were found to ferment galactose in view of the lowering in pH and carbohydrate consumption. This consumption, however, was smallest with M, followed by a slightly larger amount of consumption with MT. While, it was rather remarkable with WRT and extremely remarkable with O and RT. The types of microorganisms remained unchanged after undergoing the present experiment. Galactose consumption by these microorganisms was inferior to that of glucose. An inference was given that the reason why the galactose consumption of M and MT is weak is the inability of the galactolytic enzymes in performing their serial functions.
    In view of the findings stated above, an inference was given that the variation of O→M→WRT→RT is not a kind of the loss and gain variation of galactose fermentability but is a kind of the enforcement and weakening variation.
  • 吉崎 千代子, 福留 勇, 黒川 正身
    1961 年 21 巻 4 号 p. 458-461
    発行日: 1961/07/28
    公開日: 2010/09/09
    ジャーナル フリー
    Availing the findings of experimentally induced typhoid, statistic analyses were attempted on the nature of the distribution curve of the survival time of the animal died by the infection as well as on the bacterial count of the visceral organs of survival animal.
    As for the availability and the significance of these statistic measures, of course further investigations on a number of different materials and, probably, separate experiments are necessary. But, the findings of the present study suggest that they, at least, are worth while for further investigations.
  • 辺野 喜正夫, 藪内 清, 吉崎 千代子
    1961 年 21 巻 4 号 p. 462-464
    発行日: 1961/07/28
    公開日: 2010/11/19
    ジャーナル フリー
    One kind of non-mannitol fermenting Shigella sonnei was isolated. Its characters were investigated biochemically and immunologically. Sensitivity to various antibioticus was measured.
    No difference was noticed from mannitol fermenters, except that it cannot utilize mannitol. It was found a rare case to experience such a strain in Japan.
    Possibility of outbreak by this king of organism in Japan was discussed from the literal point of view.
feedback
Top