昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
35 巻, 2 号
選択された号の論文の9件中1~9を表示しています
  • 特に所属リンパ節をも含めたいわゆる正常乳腺と乳癌乳腺との比較を中心とした臨床面と, 133Xe-clearance curveを用いた腫瘤内血流量測定による乳癌診断への試み
    清水 敬介
    1975 年 35 巻 2 号 p. 101-112
    発行日: 1975/04/28
    公開日: 2010/09/09
    ジャーナル フリー
    The study was performed on the so-called normal mammary glands and lymphnodes. The difference between normal glands and mammary glands of breast cancer was discussed and studied.
    Furthermore, X133clearance as the new trial was attempted to the diagnosis on the breast cancer.
    The results obtained were as follows :
    1. 38.9% of so-called normal mammary glands have palpable tumors. Most of them are though to be mastopathie in clinical and 6.7% of these cases have palpable axillary lymph nodes.
    2. 98.6% of chief complaint in breat cancer are distinct mammary tumor. In addition 61.8% in these cases have palpable lymph nodes.
    3. As for the frequency of so-called normal mammary gland with palpable tumor, it was the highest in the age of 30 (69.2%) . On the contrary, as for the frequency of breast cancer, in the age of 40 (36.7%) .
    4. Slight anemia was found in the breast cancer cases, but the disturbance of liver function was seldom seen.
    5. Blood flow with X133clearance curve was poorer in scirrhous carcinoma than other benign tumors. Therefore, the method of X133clearance is thought to be a significant diagnostic tool for scirrhous carcinoma
  • 山川 晃弘
    1975 年 35 巻 2 号 p. 113-126
    発行日: 1975/04/28
    公開日: 2010/09/09
    ジャーナル フリー
    Since L-carnosine exerts a facilitating action on experimental formation of granulation tissue, the effect of L-carnosine on various kinds of experimental gastric ulcer was studied ; and the following conclusions were obtained :
    1) A slight preventive effect was noted in the development of acute experimental gastric ulcer, but scarcely any therapeutic effects were found.
    2) In cortisone-induced ulcer, combined administration of L-carnosine definitely exerted a preventive effect.
    3) In clamping cortisone ulcer and acetic acid ulcer which are experimental ulcers considered to closely resemble chronic gastric ulcer in man, subcutaneous administration of 200-500 mg/kg of L-carnosine markedly facilitated healing.
    4) L-carnosine administration completely inhibited the decrease of blood flow through the gastric mucosa seen in gastric hypermotility.
    5) L-carnosine administration induced early formation of new blood vessels in the healing process of acetic acid ulcer.
    6) L-carnosine failed to influence gastric secretion from the Heidenhein pouch.
  • 吉田 正英, 工藤 順康, 佐藤 貞之
    1975 年 35 巻 2 号 p. 127-132
    発行日: 1975/04/28
    公開日: 2010/09/09
    ジャーナル フリー
    The gall bladder of the guinea-pig was isolated and mounted in an organ bath perfusing with Krebs solution. The rectangular pulses through Ag plate electrodes were applied as an electrical stimulation. Drugs also used as a chemical stimulant.
    1. The phasic contraction was evoked by the electrical stimulation (pulse width 5 msec, frequency 20 Hz, 30 Volt and 10 sec duration) . Even after 7 hours incubation in krebs solution, same response was obtained.
    2. 1×10-7g/ml tetrodotoxin significantly depressed the evoked contraction by electrical stimulation, but no effect on the contracture was evoked by chemical stimulus.
    3. The contractile response was affected with the temperature of the Krebs solution and also calcium concentration in the saline media. Adequate temperature for the evoked contraction was about 38°C and the concentration of calcium was 3-4 mM.
    4. Forty mM KCl or 10-7g/ml acetylcholine chloride solution induced the phasic contraction following the tonic one. But these drug induced contracture was fade out, if the preparation was incubated in calcium free solution. It might be suggested that the calcium in muscle caused the tension development and that in saline media caused a maintenance of tonic contraction.
  • 矢嶋 七生
    1975 年 35 巻 2 号 p. 133-143
    発行日: 1975/04/28
    公開日: 2010/09/09
    ジャーナル フリー
    The concentrations of twenty three amino acids in blood plasma before and after hemodialysis with artificial kidney of Coif type were determined for the thirteen patients with chronic renal failure.
    1. The concentrations of glycine, alanine and valine, which molecular weight were comparatively small, and also glutamine were markedly decreased after hemodialysis.
    2. The concetration of glutamine was compared with those of glutamic acid, asparagine and asparatic acid, which had structural resemblances to glutamine. The concentration of the glutemine of the patients with chronic renal failure before hemodialysis was nearly equal to its meanvalue of ten normal persons and showed a marked decrease by hemodialysis, but the concentrations of glutamic acid, asparagine and asparatic acid before and after hemodialysis did not show such tendenecy.
    3. From the relationship between the concentrations of plasma urea nitrogen before and after hemodialysis and the residual perentage of glutamine after hemodialysis, it was shown that the residual percentage of glutamine was low in the cases with rather small difference of plasma urea nitrogen and vice versa.
    The close correlationship exists between these two variables except those of two patients with advanced renal failures. I considered from these results that the difference of the concentrations of plasma urea nitrogen before and after hemodiailysis was high in the cases with low function of urea synthesis in the liver and thir difference should be small in a subject with normal liver function.
  • 安藤 克仁
    1975 年 35 巻 2 号 p. 145-151
    発行日: 1975/04/28
    公開日: 2010/09/09
    ジャーナル フリー
    Studies on radiosensitivity of the tramsplanted tumor were carried out and following results were obtained
    1. Radiosensitivity of the tumor ran parallel to the growth rate.
    2. Malnutrition of the host after irradiation made the tumor radiosensitive, probably because sublethally damaged tumor cell did not recover.
    3. Mitotic index was well correlated to radiosensitivity and low mitotic index caused by starvation made the tumor cell to recover poorly.
    4. DNA synthetic rate measured by means of iodine labeled IUdR was not successful to correlate with mitotic rate, presumably because of the role of thymidine pool size in this experiment.
    5. Serum protein level was likely to correlate to the tumor growth, which modified the radiosensitivity.
    6. Serum oxygen was difficult to interpret, however might be compensated by erythrocytosis in starved condition.
  • ―特に睡眠脳波と血圧との関係について―
    清水 晃
    1975 年 35 巻 2 号 p. 153-165
    発行日: 1975/04/28
    公開日: 2010/09/09
    ジャーナル フリー
    For the purpose of study the central regulatory mechanism of blood pressure, simultaneous recordig of EEG, blood pressure, ocular movement, respiration, pulse, galvanic skin reflex and body temperature was carried out continuously during natural sleep. This method was selected because natural sleep is the condition in which external stimuli are blocked; and such a study appears to be necessary to study the endogenous factors in patients with essential hypertension and those with essential hypotension. In patients with hypertension, a fall of blood pressure occure parallelling the depth of sleep; while a rise of blood pressure is noted in patients with hypotension, also parallel with the depth of sleep. In normotensive subjects, along with the depth of the sleep, a mild fall of blood pressure or no change is noted. Ocular movement, galvanic skin reflex, body temperature, respiratory rate, and pulse rate fell, paralling the depth of sleep. In all three groups, the ECG showed no change except for the RR interval. The pulse wave changed to lower amplitude waves in both hypertensives and normotenives parallelling the depth of sleep, but the tendency was more pronounced in the former. Some of the hypotensives on the contrary revealed changes to a higher amplitude. The relationship with blood pressure thus appears to be more in-timate than that with the depth of sleep.
  • 舟木 正明, 永井 正彦, 四谷 敏朗, 岡松 孝男
    1975 年 35 巻 2 号 p. 167-169
    発行日: 1975/04/28
    公開日: 2010/09/09
    ジャーナル フリー
    Since Wegeler described an appendiceal stone in 1813 at the first time, the calcified f ecaliths occurs more commonly in childhood.
    But there are a few reports about appendiceal stone in childhood.
    A case of calcified fecalith in 5 years old girl which was diagnosed by preoperative abdominal roentgenogram was reported. and significance of preoperative abdominal roent-genographic examination was stressed.
  • 渡辺 千栄子, 中村 明子, 垣花 淳一, 伊東 佑英, 奥山 和男
    1975 年 35 巻 2 号 p. 171-174
    発行日: 1975/04/28
    公開日: 2010/09/09
    ジャーナル フリー
    A case of severe neonatal anemia due to fetomaternal transfusion was reported. Hemoglobin was 5.1 g/dl at birth and acute hemorrhagic schock with cardiac failure was observed.
    Mother's HbF schowed 3% total Hb (control 0.2%)
    Blood transfusion was given 110 ml in total. From 28th days after birth the patient was administered with Iron for 85 days, and no post transfusion anemia was found.
    It is thought that fetomaternal transfusion is not uncommon and important cause of neonatal anemia.
  • 杵鞭 宏育, 江頭 亨, 萩原 民郎, 菊地 隆一, 粟屋 保男, 上條 一也, 黒岩 幸雄, 池野 美恵子, 庄 貞行, 上條 一也, 今 ...
    1975 年 35 巻 2 号 p. 175-178
    発行日: 1975/04/28
    公開日: 2010/09/09
    ジャーナル フリー
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