昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
19 巻, 1 号
選択された号の論文の16件中1~16を表示しています
  • 第1報トラコーマに就いて
    市原 正文, 榎本 武一, 宮本 巖
    1959 年 19 巻 1 号 p. 1-3
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    The opthalmic examination was Performed in Kotsubo village, Zushi city on July 26 and 27, 1958. The results obtained were as follows :
    1) The subjects were consisted of 156 men and 261 females, totalling 427, which were equivalent to 11.95 ± 0.56 % of the whole population of Village (according to the investigation made on November 1, 1957) .
    2) Trachoma infected 12 men (7.6 ± 2.2 %) and 38 females (14.02 ± 2.2 %) with the higher rate in the latters. The cases were 50 (11.84 ± 1.8 %) in total and 36 (8.37 ± 1.3 %) if except those in the IV stage.
    3) Infection rate by ages : It wrs the highest showing 22.5 ± 3.8 % in those of postschool age (more than 16 years), the lowest showing 7.28 ± 1.6 % in those of school age (6-15 years) and 9.52 ± 3.6 % in those of pre-school age (less than 6 years) . A difference was significant in the rates between post-school and school ages but not so from the other group.
    4) Distribution by stages and ages : In those aged less than 16 years, 60 % were in the I stage, 32 % in the III and 8 % in the II. In those 20-30 years, only 2 cases were in the III. Those more than 40 years 56.5 % were in the IV and 43.5 % in the III. On observing three divided ages in total, the I stage was 30 %, II 4 %, III 40 % and IV 26 %.
    5) Complication was noted in 6 cases, of which 5 females, of the III stage.
  • 市原 正雄
    1959 年 19 巻 1 号 p. 4-7
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    There are a number of reports concerning the operation technics as a treatment of atrophic rhinitis. In order to get better prognosis of this disorder the various physical examinations before operation and medical approaches adapted to this disorders types must be carried not without just applying only one technic. According to above mentioned view, in was inferred that Goto's and Ichihara's technics were satisfactory for treatment of atrophic rhinitis secondary to parasinuitis and Kubo's technic was satisfactory for another types.
  • 白倉 賢三
    1959 年 19 巻 1 号 p. 8-10
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    A case of 49 aged man having nasal polyp from anterior portion of the right inferior turbinate was described. Nasal polyp of this site is so very rare as of agger nasi and nasal flood. It was observed that the origin is related with external stimuli.
  • 第1報妊娠, 分娩及び産褥各期に於ける血液中コリンエステラーゼの消長
    花村 幹
    1959 年 19 巻 1 号 p. 11-18
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    Blood cholinestarase (ChE) activity in pregnancy, delivery and puerperium, and in the patient of toxemia of pregnancy, using Benzoylcholine (BzCH) for serum-ChE and Acethyl-β-methylcholine (MecH) for erythrocytes-ChE as substrate, were studied manometrically. Following results were obtained :
    1. Serum-ChE activity were decrease gradually with progress of pregnancy, while erythrocytes-ChE activity were decrease in early stage and maintained in its lower level all throng the pregnancy. The lowest activities of both of them were shown at 9th month of pregnancy.
    2. Activities of both serum-ChE and erythrocytes-ChE were increased temporary at labor period and then decreased maximumlly at labor day. Since then they were increased gradually and reached to the control level at the 8th day in serum-ChE and the 6th day in erythrocytes-ChE following labor.
    3. Activities of both serum-ChE and erythrocytes-ChE in case of toxemia of pregnancy were shown in lower level than the normal pregnant cases.
    4. The cause of changes of activity in serum and erythrocytes-ChE in pregnancy, delivery, puerperium and in case of toxemia of pregnancy were not essential but just related on the blood concentration.
  • 第2報胎盤中のコリンエステラーゼ
    花村 幹
    1959 年 19 巻 1 号 p. 19-27
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    Cholinesterase (ChE) in human placenta, maternal and fetal blood in physiological and morbid conditions, were studied manometrically, using Acetyl-β-methylcholine (MeCh) for specific ChE and Benzoylcholine (BzCh) for non-specific ChE as substrate.
    Following results were obtained :
    1. ChE activities of human placenta were the lowest in the mid stage, while higher in the early stage, and the highest in the last stage of pregnancy bolood.
    2. Blood ChE activities of artery and vein in umbrical cord were almost the same, while remarkably higher activities were observed in maternal blood.
    3. ChE activities of human placenta were the highest in the last stage of pregnancy, and then decreased gradually with the beginning and progress of the labor.
    4. ChE activities of human placenta were lower in cases of early abortion, toxemia of pregnancy, and uterine intertia, and were high in cases of cesarean section without toxemia of pregnancy, and atony of uterus.
  • 会田 隆顕
    1959 年 19 巻 1 号 p. 28-38
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    1. One, 5, 10, 15, 20. 25, 30, 40, and 50 mg/kg of histamine were injected into young mice continuously for a period of 30 days. Then they were divided into two groups, such as those expiring at an early period (acute group) and those sacrificed after 30 days (chronic group) . A histopathological study was carried out with special reference to the changes of the lingual gland (Ebner gland) .
    2. More remarkable changes in Ebner gland were observed in the former group. The changes become more conspicuous with increase of histamine in both groups, although this tendency was slight in the reticulum fibers of the basal membrane.
    3. In the chronic group the changes caused by a large dose of histamine (Vacuolar degeneration, liquefaction and destruction of glandular epithelial cells, vacuolar degeneration and destruction of epithelial cells of the secretory duct, congestion of interstitial tissue) appeared together with the case of the acute group. (irregular arrangement, dissociation, cloudy swelling of glandular epithelial cells, desquamation and cloudy swelling of epithelial cells of the secretory duct, lymphocytic infiltration in interstitial tissue) .
    4. The changes of the aeticulum fibers of the basal membrane were almost parallel with the pathological changes of the glandular epithelial cells in both group. The correlation to the degenerative changes of the glandular epithelial cells is stressed.
    5. The various degenerative changes of the lingual glands in the present experiment were caused by the secondary direct and toxic action of histamine upon the Ebner gland.
  • 鈴木 静夫, 入江 棟一, 陶 易王, 尤 伝石, 斎藤 裕, 芦川 恒夫
    1959 年 19 巻 1 号 p. 39-43
    発行日: 1959/03/30
    公開日: 2010/11/19
    ジャーナル フリー
    “Damping foctor ” of Monnier was calculated basing on the electrical stimulation theory of Hill, and the following formula was obtained.
    B=1/2√3 (√4k+3λ/k-√k/4k+3λ)
    (B: damping factor, κ : constant of local potential, λ : accomdation constant in Hill's theory)
    κ and λ were measured experimentally on the sciatic nerve of Bufo vulgaris, and utilizing these values, the damping factors were calculated according to the above formula.
    The value obtained was 1.09 ± 0.04, which coincided roughly with the value obtained by Monnier who mersured this value according to his definition of the damping factor.
    The effect of various ions upon the damping factor were tested in the sciatic nerve.
    Increase of C _??_ or decrease of K _??_ in the environmental fluid caused elevatation of the value of the damping factor, however, decrease of C _??_ or increase of K _??_ caused decrease of it.
    When the concentration ratio of C _??_ and K _??_ in Ringer's solution was kept constant and the concentration of both irons was decreased or increased simultaneously, damping factor was slightly changed.
    Citrate ions caused decrease of the damping factor.
  • 佐川 文明
    1959 年 19 巻 1 号 p. 44-59
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    The early pathological and histological changes in liver of wistar rats fed with 0.03% 2-acetylaminofluorene (2-A.A.F.) were studied. A few observations were made on the cystoadenomatous formation and on the relation between liver cells and epithelial cells in the bile duct.
    1) The small clear cells (epithelial cells originated from small bile duct) were found around the portal area at the 7th day following the administration. The dendric proliferation of these cells was seen in the space of liver cell trabeculae with the elapse of time. It was found that the periphery of the liver lobules was surrounded by small clear cells and the psudo-annular cirrhosis in liver after one month following the adminstration. At this stage some of the small clear cells have changed into cystoadenoma.
    2) The mode of development of cystoadenoma was as follows. The stagnation of the secret was occurred, as the result of stenosis in the lumen of ductlike structure of small clear cells, thus the cystic dilatation was revealed as cystoadenoma.
    The size and form of cystoadenoma are rich in variety. The form of epithelial cells lining the cyst was flat, cuboidal, cylindrical and so on.
    3) On the 31st day following the administration marked progressive or hyperplastic changes of the liver cells were observed. This change indicates the nodular hyperpaasia.
    4) These small clear cells were stained differently from the liver cells or the epithelial cells in the bile duct by PAS-methylgreen staining. The cytoplasm of non-progressive liver cells contained PAS-positive large granules abundantly. PAS-positive granules in the progressive liver cells were small and scatteredly (prominent decrease in the number of granules) . The transformation and decrease in the number of mitochondriae were found remarkably by Heidenhain's iron haematoxylin and Altmann's stain. PAS-positive granules were not found in the cytoplasm of epithelial cells in the small clear cell. The nuclei and cell membrane of these cells were stained green with methylgreen. The granules of mitochondria did not noticed with Heidenhain's iron haematoxylin and Altmann's stain.
  • 水谷 薫
    1959 年 19 巻 1 号 p. 60-70
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    By repeated painting of 3-methylchoranthrene (as 1.5% benzene solution) to the skin of d d strain mice about 15 times (twice a week for 5 weeks and then once a week for ca. 5-6 weeks), transplantable generalized lymph nodes swelling in mice with leukemic change in the peripheral blood were obtained.
    1. On about 100 days following the administration in 8 cases out of 60 mice, the generalized lymph nodes swelling (lymphomatosis Mider, G. B., et Morton, J. J., 1939) was observed. At the same time, when the lymphomatosis occurred, these mice suffered with acute leukocytosis, which was examined hemocytologically as well as pathohistologically. This is the acute leukemic lymphadenosis by 3-methylchoranthrene administration.
    2. Successive transplantations have been made until 14 generations by the transplantation of the tissue of the swollen lymph nodes into the subcutaneous tissue of the same strain mice. However, they died by the epidemic pneumonia in the 14 generation unfortunately.
    The ratio of transplantability was about 400 (68 cases out of 180 mice) . The transplanted tumor grew up rather rapidly at the site of inoculation expansively with the tendency of infiltration to the surrounding tissue. Tumor-bearing mice died by cachexia.
    Leukemic changes were observed in 4 cases out of 68 mice in which the transplantation succeeded. It is very curious that these 4 cases did ont show marked swelling of the lymph nodes, the spleen, the liver and the kidneys, although the pathohitological features were quite the same as above-mentioned findings. When and how the transplanted mice obtained the leukemic phase will be the theme for the further study.
    Transplantable leukemic lymphadenosis (chiefly as subcutaneous tumor in transplanted mice, but sometimes as lymphatic leukemic) obtained relatively easily by the administration of 3-methylchoranthrene.
  • Kazuo Mori, Kenichi Okamoto, Tsuko Nakagome, Kenichi Sugiura, Katsuhik ...
    1959 年 19 巻 1 号 p. 71-74
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
  • Kazuo Mori, Kenichi Okamoto, Tsuko Nakagome, Kenichi Sugiura
    1959 年 19 巻 1 号 p. 75-77
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
  • Kenichi Okamoto
    1959 年 19 巻 1 号 p. 78-81
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
  • Katsuhiko Matsumoto
    1959 年 19 巻 1 号 p. 82-85
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
  • 第4報Paperdisk法によるgalactoseの発育障害作用
    福留 勇, 矢吹 二郎, 大西 泰二, 山本 昇, 近藤 清繁, 林春 松, 石井 静也, 朝倉 徳夫
    1959 年 19 巻 1 号 p. 86-95
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    The present paper deals with the studies made on the growth inhibitory action of galactose against the Mutabile-type variants (Murase) of the several kinds of enteric bacteria. Method employed for the preparation of titrating medium is essentially the same as the cup method for the titration of penicillin units. Namely, 0.01ml of galactose solution in varying concentrations is pipetted out onto a paper disk of 6 mm in diameter, and the growth inhibition zone is measured which will be produced around the disk following 24 hours incubation at 37 C.
    M-type variants of E, coli, paracoli-type E. coli, S. paratyphi A, S. paratyphi B, S. typhi-murium, S. typhi, S. enteritidis and Shigella sonnei were isolated by Murase's method.
    Galactose sensitivity test was made on the M-type variants of the following kinds : 1) those derived from a single broth culture, 2) those derived from the same strain but differnt broth cultures, 3) those derived from the cultures once grown on the medium containing galactose, 4) those derived from the strains once grown on the medium containing lactose, 5) those derived from the strains which have never been in contact with galactose, or ldctose, 6) new variants and 7) old rough variants.
    Results of the experiment revealed that some of the M-type variants tested were highly sensitive to an extremely small amount of galactose. Namely, some variants showed a growth inhibition zone even at a concentration of 0.8γl, while some failed to show it even at a concentration as high as 1.6γl. This galactose sensitivity of M-type variants appear to have no relation with the difference in the condition of their isolation.
    Further, the M-tye variants which have undergone changes being cultured on galactose medium can grow well on ordinary agar medium. Thus, it is believed that the strong growth inhibitory action of galactose on M-type variants appears only when they are grown on the medium containing galactose.
    While, the lethal dose of galactose fails to show any appreciable damage on the growth of M-type variants when the cultures are kept in a refrigerator or when they are kept in an incubator for a night on the medium containing no other nutrients. In other words, the bactericidal power of galactose seems to appear in respond to the growth of microorganisms.
    Accordingly, the growth inhibition zone around the galactose disk may be produced by the sugar diffusing out of the disk being sharply defined from the area of abundant growth.
  • 下島 宏登
    1959 年 19 巻 1 号 p. 96-106
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    Nicotine was used for the histopathological study concerning the toxic disturbance the central nervous system.
    Subcutaneous injections of nicotine were given to mice daily for a period of 30 days. The animals were then sacrificed and their brains were studied histopathologically.
    1) The nerve cells demonstrated swelling, vacuolar formation, homogenization, liquefaction, edematous changes, localized“Ausfall”, vocuolization, swelling of nuclei, homogenization and disappearance of nude.
    2) The majority of the degenerative changes of nerve cells are anoxemic changes induced by the toxic action of nicotine, or are combined with hydropic encroachment directly Teaching the cells from the surrounding tissues.
    3) Nicotine acts upon the brain as a histotoxic hypoxydase ; it reaches the vessels and induces a primary indirect changes, while on the other hand, it induces a secondary direct change.
    4) Edema is the most remarkable among the primary indirect changes. Hemodynamic edma plays the main role, and disturbance of the blood-brain barrier is extremely mild, and PAS-positive substances can hardly be detected.
    5) Edematous uncertainty is the morphological figure of the edematous changes of each element of the nervous tissue developing from the rarefaction in the gray substance, and in the white substance they show transitional figures to demelinized changes by the abundant medullated nerve fibers.
  • 山本 常市, 市原 正雄, 横川 札二郎, 宮尾 赳, 小松 晃, 神尾 鋭, 白倉 賢三, 竹内 志郎, 上野 正一郎, 佐久間 義房, ...
    1959 年 19 巻 1 号 p. 107-111
    発行日: 1959/03/30
    公開日: 2010/09/09
    ジャーナル フリー
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