The relationship of roentgenographic findings and pulmonary arterial pressure was studied upon the 20 patients with mitral srenosis and compared it with normal cases.
In this study it was proved that Kerley-B-line, perivascular haziness, and promonent reticulation in lower pulmonary lobe often found in the cases of mitral stenosis accompanied with pulmonary hypertension, but not in the cases with normal pulmonary pressure.
Bulging of the pulmonary arterial segment and enlarged right hilar shadow were found in almost everyy cases. About these roentgenographies, geometrical studies were performed using 1/2 trans thoracic diameter, the diameter of pulmonaty arterial segment in the cardiac silhouette and the size of most prominent point on the left cardiac border. The relationship of pulmonary hypertension and roentgenographic findings were discussed in each case. And also discussed about the causes of roentgenographic f alse-diagmosis between mitral stenosis and lung-diseases.

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Since Cabrera and Monroy described that the systolic (pressure) and diastolic (volume) overloading of both ventricles are well reflected in the electrocardiogram in 1952, many reports on this subject have been presented.
It is generally accepted that the abnormal Q wave accompanied with high R and T waves on the chest lead (V₅·V₆), shows left ventricular volume overload.
In the case of M. I., hemodynamic feature shows left ventricular volume overload, on the other hand, in M. S. it should be considered to show the left ventricular hypo-volume loading. Therefore, Q wave of the left chest lead is lowered or disappeared in the severe M. S., and it increased in height when complicated with M. I.,
The relation between Q wave and M. S. was discussed in this paper, reviewing 15 cases with M. S., 3 with M. S. I., 6 with M. I. and other control group, which include 13 cases of L. U. L., 16 of L. O. L. and normal 15 cases.
As shown in the table, Q wave of left chest lead was well correlated with the left hemodynamic differences, especially in the case of M.S. and M.I.. Consequently it was very important to decide the grade in M.S., and to obtain successful result of commissurotomy and to differentiate complicated valve diseases.

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1) Antibacterial activity of 21 kinds of penicillin derivatives was tested against 18 kinds of bacterium. It was found that their activity fairly varied according to the kinds of bases used.
P-aminobenzaldehydethiosemicarbazone-Pc and dl-p-nitrophenyl-2-amino-1, 3-propanediol-Pc showed high antibacterial activity against gramnegative bacteria which had low sensitivity to penicillin and p-aminobenzaldehdethiosemicarbazone-Pc and p-aminosalicylicacid-Pc showed rather high antibacterial power against Myco. tuberculosis H 37 RV that was not so sensitive to penicillin.
2) Various kinds of salts obtained by making various organic bases react to penicillin showed the same grade of activity as procain-Pc against grampositive cocci sensitive to penicillin.
3) Pyrimidine-Pc showed much higher antibacterial activity than procain-Pc against Br. melitensis.
4) It was studied how the drug resistance of Staph. aureus 209 P and Terashima to various penicillin derivatives would develop. It was found that Staph. aureus 209 P and Terashima got resistance against metal (Na and Ca) salts of penicillin as well as against its organic salts. They got resistance more easily against the former.
Penicillin resistant variants of bacterium were likely to show rather poor growth in the culture media.

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Antibacterial activity of 21 kinds of penicillin derivatives was tested in vitro and reported in the previous report (part 1) of this study. In this report, experiments were made on the toxicity in mice, titration of the blood level and protective effect in experimentally infected mice.
Following results were obtained.
LD50 of the 21 kinds of penicillin derivatives in mice varied from 1.5 mg to 4.5 mg. When inoculated subcutaneously. Aminoacidester-Penicillin was rather lower in toxicity and prccain-Pc and p-aminobenzaldehyde thiosemicarbazone-Pc were relatively stronger. When injected subcutaneously, the toxicity of penicillin salt seemed to be different according to the base reacted to penicillin. But the toxicity was very low when administered orally, and all the mice survived, even though a dose of 75 mg was given. Employing the mice infected with Str, equi, 5 kinds of penicillin derivatives were tested of their protectivity. When a dose of 30 units was used, 3-6/10 of the mice died, but when a dose of 90 units was used, only 0-2/10 died.
The death rate seemed to be reduced by the increase in the dose given. Further more it was found that d.1-p-nitrophenyl-2-amino-l.3-propanediol-Pc, 1-leucineethylester-Pc and p-aminoben-zaldehyde thiosemicarbazone-Pc seemed to be less toxic than procain-Pc and that are quite promis-sing agents in the therapeutic field.
Two kinds of pyrimidine-Pc and 3 kinds of aminoacidester-Pc were as effective as procain-Pc and penicillin G-Na in experimentally produced pneumococcal infection, but it seemed advisable to give a dose over 50 or 100 units for better results.
The therapeutic effect of pyrimidine-Pc in Type 1 pneumococcal infection in mice seemed to be larger, when given in combination with sulfamine.
In the case of mousetyphoid, all animals died. Judging from the mean survival days of experimental animals, however, the survival period of animals administered of d.1-p-nitrophenyl-2-amino-l.3-propanediol-Pc seemed slightly longer than those of administered of 2-amino-4-methyl-6-methoxypyrimidine-Pc.
Thus, it is believed that a number of newly prepared penicillin derivatives are as effective as procain-Pc or penicillin G-Na.

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So-called mucoid M and mucoid RT mutated from the Mutabile-type Var. (Murase) which was obtained from the old broth cultures of Salm, typhi-murium, Salm, enteritidis and E, coli do not grow on 0.5-1% sodium sulfite agar. Their growths are completely inhibited in both surface and deep cultures. On the contrary, the original strain, Mutabile-type Var., the RT mutated from the Mutabile-type Var. and a very small part of mucoid RT are not inhibited by the above dose of sodium sulfite. If both kinds of organisms are mixed and present in the same culture, only resistant strains would grow on this medium.
Mucoid variants mutated directly from the original type of Salm, typhi-murium and that of Salm. enteritidis were resistant to sodium sulfite, but a mucoid variant of Sh, flex. 4a was susceptible.
From the above experiments, it was found that the growth of mucoid M and mucoid RT are specifically inhibited when plated on to sodium sulfite medium.
Utilization of this phenomenon may enable to know the rate of mucoid M→nonmucoid M, mucoid M→mucoid RT, and mucoid RT→nonmucoid RT mutation.
Directions and orders of the mutation of such variants have already been investigated in the authers laboratory.

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