昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
27 巻, 6 号
選択された号の論文の6件中1~6を表示しています
  • 山崎 英胤
    1967 年 27 巻 6 号 p. 463-476
    発行日: 1967/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    A mutant (mucoid var. of Mutabile-type var. Murase) was found in author's laboratory which has two kinds of weak characters, one being galactose-sensitivity and the other mucoid growth. Even if one of them might be lost by mutation, the other character would still remain.
    A study of weak live vaccine was undertaken utilizing such a peculiar mutant of. Salmonella and the antibacterial activity of the host to the mutant.
    Following points were cleared.
    1) Mucoid M of S. enteritidis and S. typhimurium are found weakly virulent mutants for mouse, retaining the antigenicity as M. Mice immunized with the mutant resist to the challenge of wild virulent type.
    2) Mice sometimes die from the sepsis of RT, the backmutant to the wild type, by inoculation of mucoid M.
    3) Mucoid RT is less virulent than the original.
    4) Mice sometimes die from the sepsis of RT by inoculation of mucoid RT more often than mucoid M.
    The directions of mutation is such as mucoid M→M→RT when the mucoid character is lost, and mucoid M→mucoid RT→RT when the M character is lost.
    If both characters could be lost at the same time, mucoid M→RT should follow. But this kind of mutation is rarely experienced in vitro test.
    From the above experiment, it was cleared that the backmutation of mucoid M to the original may occur at a certain ratio in various ways in vitro as well as in vivo. So it is hoped to obtain a mutant with the mutation rate as low as posssble, rich in antigenicity, and stable in these characters. In author's experiments, both mutation rates of mucoid M to mucoid RT and mucoid M to M are roughly estimated as 104to 1, and thus the death of animal occured by thee backmutant. This observation, however, may introduce a new conception for the vaccine prophylaxis of typhoid fever.
  • 鈴木 五郎
    1967 年 27 巻 6 号 p. 477-496
    発行日: 1967/06/28
    公開日: 2010/11/19
    ジャーナル フリー
    Phonocardiographic studies were carried out in 102 patients with pulmonary tuberculosis. In order to know the relations between the second heart sound and the pulmonary circulation, right heart sound and the pulmonary circulation, right heart catheterization was performed in 37 cases.
    The results obtained were summerized as follows :
    The grade of interval in split second heart sound had direct proportion to the stroke volume and inversed proportion to the pulmonary pressure and the total pulmonary vascular resistance.
    In the other hand, ratio of the relative amplitude of the two components in the split second heart sound at the pulmonary area showed that pulmonary component was higher than aortic component when the pulmonary pressure and the total pulmonary vascular resistance increased. But they showed scanty to of phonccardiogroms as reflected cardiovascular hemodynamics. becouse the relative amplitude of the second heart sound skemed to be altered by various factors, i. e. rotation of the heart, locations and extents of the f ccus, cavity and adhesion.
    The abnormal systolic murmurs were observed mostly on patients with left sided thoracoplastics.
    Two types were divided by differences of cycle range of the systolic murmurs. First was“pure”type, second was“distorted”type.
    It was thought to be due to differences of resonance by vortex with vascular wall or surrounding tissue upon the vascular system.
    One case showed diastolic murmur, but its cause was unable to clear.
    The split first heart sound was physiological phenomena, therefore have no pathological significance of pulmonary tuberculosis.
    The relation between the pulmonary function and the second heart sound scarecely correlates.
  • 山田 重男, 我妻 〓彦, 種村 岩美, 海野 勝男, 船渡 泰
    1967 年 27 巻 6 号 p. 497-501
    発行日: 1967/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    We investigated the lacalization of histamine inactivating substance in amphibia and obtained the following conclusions.
    1. The histamine inactivating substance was mostly concentrated in intestine and liver, but less in kidney, heart, lung, muscle and brain of frog.
    2. These substances also showed the most high concentration in intestine and liver, but less in brain, muscle, heart, kidney and lung of toad.
    3. It may not be stated that the localization of histamine inactivating substance in amphibia was quite different from that in mammalia.
  • 栗原 洋
    1967 年 27 巻 6 号 p. 502-511
    発行日: 1967/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    The present histopathologic studies were performed by the following ways. Parathion was subcutaneously injected into mice devided into groups receiving 2 mg/kg, 4 mg/kg, 8 mg/kg, 16 mg/kg and 24 mg/kg, respectively, twice a week. Secondary, on completion of the above mentioned injections, (for a total 12 times), the female mice were mated with male mice. The newborn young from them were killed on the 3rd day of life, and were subjected to histopathathologic examinations as were the livers withdrawn from the mothers (about 8 months after birth) . Hematological examinations comprising erythrocytes, hemcglohin, erythrocyte resistance, erythrocyte diameter, etc. were also done.
    1. The animals given 24 mg/kg (to 4 times injected) to 16 mg/kg (to 8 times) as acute groups exhibited the following histopathologic findings of the liver : the irregular funicular arrangement, cloudy swelling, and vacuolar degeneration of the liver cells; nuclear degeneration; loss of glycogen; capillary hyperemia; and the congestion of the central vein.
    2. The animals given 8mg/kg, 4mg/kg (9-29 times) or 2 mg/kg (25-61 times) as the subacute and chronic groups showed the histopathologic changes of cytologic degeneration of the liver more marked with the lapse of time than in the acute groups. At the same time edema was observed around the central vein, in the stroma, and around the blood vessels. In the subacute group, the hypertrophy and edematous dilatation of the interlobular connective tissue were especially remarkable, which seemed to tend progress into fibrosis as tissue reaction and reparatory process. Changes due to histologic damages (lytic changes and necrotic area) were of the highest incidence in the group given 4 mg/kg.
    3. The histologic findings in the newborn young consisted mainly of the pathologic changes of parenchymal cells, the congestion of the central vein, and the edema of Glisson's capsules.
    4. The pathologic changes in the young were generally similar to but milder than those in the mothers. Those less pathologic changes in the young may have come from the inhibition, by the placental barrier, of the transfer of metabolic disturbance from mother to fetus.
    5. As for the hematologic findings, the erythrocytes and hemoglobin showed an anemic tendency increasing with time. Very slight unevenness in the size of erythrocytes and the deformation of erythrocytes wers observed. The minimal erythrocyte resistance was practically normal, while the maximal erythrocyte resistance tended to drop, mostly in the 8 mg/kg group and the 4mg/kg group.
    6. In the acute and chronic deaths following the admininistration of Parathion, the hepatic histologic changes including cytologic changes and stromal changes were found practically paralleled to the hematologic changes observed.
    7. The mechanism of develpment of various hepatic pathologies as observed in the present experiment is believed to be as follows. Parathion administered causes directly the changes of the parenchymal cells and brings about toxic anemia due to the abberation and change of the blocd elements, resulting in hypoxidose. The hypoxia affects the blood-vessel walls, damages the liver cells and produces reticular fibrosis due to the edema and edematous changes in the stroma and around the blood vessels. Those changes are followed by the develpment of reparatory process. At the same time, the above changes have the possibility of developing into edemasclerosis, which may strongly tend towards fibrotic sclerosis
  • 直江 史郎, 菅 剛猛, 佐藤 邦彦, 謝 啓掌
    1967 年 27 巻 6 号 p. 512-515
    発行日: 1967/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    A case of adenocarcinoma of the sigmoid colon in a 16 years old girl is reported. A few relevant literature are reviewed.
  • 鈴木 快輔, 松石 正治, 佐藤 正, 秋川 至, 劉 弘文
    1967 年 27 巻 6 号 p. 516-518
    発行日: 1967/06/28
    公開日: 2010/11/19
    ジャーナル フリー
    An interesting case of gall-stone with an enclosed kernel due to the suture was experienced and a review performed on this preoblem.
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