昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
38 巻, 3 号
選択された号の論文の12件中1~12を表示しています
  • 今村 一男, 吉田 英機, 池内 隆夫, 斉藤 豊彦, 檜垣 昌夫
    1978 年 38 巻 3 号 p. 245-251
    発行日: 1978/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    We mentioned about the present ways of treatment of the bladder carcinoma ; surgical, physical, radio and chemical therapy.
    (1) For the low stage (till B1 or T2) tumors, chemical, physical therapy and/or electroresection, -coagulation and partial cystectomy by way for surgical treatment are employed.
    (2) For high stage, when the tumors are limited in the bladder, they are treated with total cystectomy. But when the tumors are localized in a small part of the bladder, partial cystectomy can be also employed.
    (3) In case the tumors have already spread over the bladder, the bladder isolation or other treatments should be selected.
    Further study of the chemical treatments should be encouraged hereafter.
  • 有田 昌彦
    1978 年 38 巻 3 号 p. 253-262
    発行日: 1978/06/28
    公開日: 2010/11/19
    ジャーナル フリー
    The results of RAST to mite, silk, egg white, shrimp and buckwheat allergen were compared with those of clinical allergy diagnosis by scratch tests, case history and serum IgE levels. Seventy children were selected because of suffering from atopic allergy to more than one substance, resulting in bronchial asthma and other symptoms.
    In this study, RAST was performed using batches of allergen perticle complex and 125I-labbeled anti-IgE as in the study reported by Wide et al. APC were prepared in the method described by Ceska et al.
    An over-all correlation between scratch tests and RAST was established in 76.2 per cent. Result of RAST showed higher correlation with scratch tests to inheller antigens.
    In any antigen, serum IgE levels were not correlated with RAST counts. Clinical history of food hypersensitivities was well correlated with positive RAST.
    Finally, significantly positive correlation of result of carefully performed skin tests with RAST values suggests the possibility that the RAST can be employed as reliable diagnostic aid.
  • 三田 〓, 太田 秀一
    1978 年 38 巻 3 号 p. 263-272
    発行日: 1978/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Lipopolysaccharide (LPS) の生物活性と構造の研究から, 近年lipid Aに対する抗体産生が明らかとなって来た.しかしこれらはいずれも血清を用いた反応系であり細胞レベルに於ける解析はほとんどなされていない.本研究は, マウスに於ける抗1ipid A抗体産生細胞系の動態を明らかにする目的で, lipid A刺激に対するリンパ系細胞の反応を, Cunningham法及びRosette法を用いて検討した.
    I実験材料と方法
    1) Salmonella minnesota R595 (Re mutant) の細胞壁より分離されたglycolipid (2-keto-3-deoxy-octonate-lipid A以下KDO-lipid Aと略す: M W.約6000) 及びlipid A (MW.3000~2500) .
    2) 免疫用担体としてR595の菌体を1%酢酸で水解し, KDOを除去した酢酸加熱菌体 (Acid heated bacterial cell以下AHと略す) 及びメチル化ウシ血清アルブミン (MBSA) の2種類を用いた.
    3) 動物は, 4週令のddY系雄性マウスを使用した.
    4) 抗lipid A抗体産生細胞の検出には, Cunningham法で検討し, R595-alkali-lipid A (以下単にalkali-lipid Aと略す) でcoatingしたヒツジ赤血球 (SRBC) と1×107個/mlの割合に懸濁した脾細胞, 或は胸腺細胞とを混合し, 37℃, 1時間のincubation後出現したplaque-forming cell (PFC) を算定し, 各組織当りの総数を換算した.なおindirect法では, 抗マウスIgG抗体 (Miles) を用いた.
    5) ロゼット形成細胞 (RFC) の検出は, Biozziらの方法を用いた, 上記方法で調整された細胞懸濁液とalkali-lipid A coated SRBCとのreaction mixtureを4℃で1夜放置後, RFCを算定した.
    II結果
    1) AH (200μg, /マウス) とalkali-lipid A (20μg/マウス) conjugateのi.v.投与で数日後に抗 lipid A-plaqueが見出された (約100PFC/脾) これは, MBSAとconjugateした時, 又Freund Adjuvantと共に皮下投与した時にも検出された.
    2) R595-glycolipid単独i.p.投与群でlipid Aに対するantibody plaqueが確認されたがlipid A単独投与群では観察されない.
    3) しかしながら, この時RFCが, glycolipid投与群と較べて数は少ないとは言え, lipid A群にも出現している.
    4) glycolipid単独投与群の胸腺細胞中に抗lipid A抗体産生細胞が見られた.
    本実験は, 血清抗体レベルで把握し得なくても感度の高い測定法を用いれば細胞レベルで抗lipid A抗体の産生を認め得る事を明らかに示している.またalkali-lipid Aの免疫原性は極めて弱いがReglycolipid単独でもリンパ系の細胞をPFCやRFCに分化させるabilityの有る事を示し得た.すなわち担体を使用しなくても1ipid Aを動物に投与すれば抗原刺激となり得る事を示している.
  • ―特に分化発育の他臓器との相関性について―
    勝股 真人
    1978 年 38 巻 3 号 p. 273-295
    発行日: 1978/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Of 279 cases, which have been autopsied at the 1st Department of pathology, Showa University School of Medicine during the past 6 years from 1971 to 1976, 161 still-born or neonatal infants who were born from mother who had a disease that could give rise to so called immature, postmatuated, and malformed infants were excluded from this research and the rest 118 infants classified into AFD, SFD, LFD according to gestational weeks and body weight. The differentiation and development of the thyroid during the late half fetal and neonatal perioid of each case was studied histopathologically. Moreover, the other internal organs were correlated with the thyroid gland during these periods. That is, the differentiation and development were compared histopathologically
    The results obtained are as follows ;
    1) On SFD, most cases reveal only the first development but some cases reveal the second development in early stage, and in each case differentiation and development between parenchyma and mesenchyma often shows lack of balance.
    2) On LFD, the first and the second development were observed at a higher rate than on SFD. And in each case differentiation and development between parenchyma and mesenchyma were in parallel equally on AFD.
    3) On neonatal stage, the differentiation and development of the thyroid gland were observed only on the thyroid before completion of the first development, but on the thyroid, either the first development is completed at birth or, the differentiation and development of thyroid gland shows a tendency not to progress.
    4) On the late half fetal stage, the differentiation and development of the thyroid gland showed characteristic two phase pattern and differed from that of the other organs, lung, kidney and aderenal gland.
    And abnormality and immaturity of the development and differentiation of the thyroid gland on SFD and LFD were extremely remarkable compared with that of the other organs. So the author infers that the fetal thyroid gland develops most variously histopathologically compared with the other organs.
  • 渋谷 正直
    1978 年 38 巻 3 号 p. 297-304
    発行日: 1978/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Neurosecretory neurons were identified in the rat supraoptic nucleus (SON) by the antidromic response to stimulation of the neurohypophysis. I investigated the effects of inhalation anesthetics (nitrous oxide, halothane, diethyl ether) on the unit activity of antidromically identified neurohypophysial neurosecretory neurons. As inhalation of anesthetic agents, 67% nitrous oxide-oxygen (GO), 0.3%-0.5% halothane-oxygen (OF), 0.3%-0.5% halothane-67% nitrous oxide-oxygen (GOF), 6%-12% diethyl ether-oxygen (OE), 6%-12% diethyl ether-67% nitrous oxide-oxygen (GOE) were studied in 5 identified units respectively.
    Inhalation of GO showed no change in spontaneous firing rate of the units. OF and GOF showed variant changes of the unit activity.
    As the case of OE and GOE, 4 out of 5 tested units exhibited inhibition of the unit firing after inhalation respectively.
    From these results, it was concluded that the most of neurohypophysial neurosecretory neurons of the rat supraoptic area were inhibited by inhalation of diethyl ether.
  • 鎌田 康夫, 武重 千冬
    1978 年 38 巻 3 号 p. 305-314
    発行日: 1978/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    無麻酔, 無拘束家兎の中脳中心灰白質, 中脳網様体中心部から微小電極を用いて単一ニューロン活動を記録し, 仰臥位, 耳の強圧などの動物催眠を誘起する方法や針刺激によって反応するニューロンを検索した.これらの操作による反応は自発性放電の頻度の増大か減少であり, 30匹の家兎の89個のニューロンにつき126回の操作を行い, 増大するニューロンは28, 減少は63, 不変は35であった.放電頻度の変化の様相は三種の操作で異なり.針刺激の場合, 刺激開始後潜伏期をおいて変化が始まり, 刺激終了後も変化がしばらくの間持続した.
    仰臥位では変化は直ちに始まり, 後効果は僅かにみられた.耳の強圧では徐々に変化が進行し, 後効果もみられた.
    三種の操作で反応するニューロンの64%は二つ以上の操作で共通して反応し, かつ反応の方向も同じであった.また静注したモルヒネによっても共通に反応し, その反応の方向も同じであるニューロンが多くみられた.侵害刺激に反応するニューロンは, 仰臥位や耳の強圧時には反応が消失した.
    視床ニューロンは仰臥位や耳の強圧で反応するが, その反応の方向は同じであったものはごく少なかった.
    得られたニューロン活動の変化から, 針麻酔は中脳中心灰白質が内因性モルヒネ様物質によって駆動され, 下行性抑制が働いて鎮痛が起こり, 動物催眠の鎮痛と, 針麻酔の鎮痛に共通機序が働く可能性を論じた.
  • 一般薬理作用
    中山 貞男, 松尾 廣之, 能美 稔, 坂本 浩二, 豊島 良枝
    1978 年 38 巻 3 号 p. 315-322
    発行日: 1978/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    We have investigated the general pharmacological activities of diisopropyl 1, 3-dithiol-2-ylidene malonate (NKK-105), and obtained the following results.
    1. NKK-105 has shown a transient inhibitory effect on respiration, and lowering of blood pressure in rabbits by intravenous injection by a dose of over 10 mg/kg.
    2. It has shown an inhibitory effect on the isolated hearts of guinea pigs with a dose of over 1×10-5g/ml, and had no effects upon preatroinization.
    3. It has also shown a same inhibitory effect on the isolated smooth muscles of guinea pig trachial muscle, rabbit ileum, guinea pig ileum, rat uterus and guinea pig vas def erens with a dose of over 1×10-6-1×10-5 g/ml. Muscle contraction induced by acetylcholine, nicotine, oxytocin, noradrenaline and barium chloride or electrical stimulation has been inhibited with pretreatment of NKK-105.
    4. On the intestinal ability to transport charcoal meal in the intestine of mice, it has also shown an inhibitory effect with a dose of over 100 mg/kg.
    5. NKK-105 has increased excretion of urine and electrolytes in mice and rats with a dose of 10, 50 mg/kg, p.o., however, it has shown an inhibitory tendency with a dose of over 250 mg/kg, p.o.. Additionally, NKK-105 has never had any effect on serum electrolytes with a dose 500 mg/kg, p.o..
  • 特にステロイド投与量と加齢の影響について
    永野 聖司
    1978 年 38 巻 3 号 p. 323-332
    発行日: 1978/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Pituitary-adrenocortical functions were studied in those patients who had been treated with adrenocortical steroids by means of insulin stress test, rapid ACTH test and ACTH Z (depo-tetracosactide) intramuscular injection test. Particulary, it was investigated in connection with the effects of the total dosage of steroids administered and of patient's age.
    In patients received 2000-5000 milligrams of steroids in predonisolone base, the blood cortisol response was subnormal in insulin stress test, and it was markedly decreased in patients receiving over 5000 milligrams, especially in aged patients scarcely any response could be found.
    By rapid ACTH test, adrenocortical responsiveness reduced in the old ages already in patients receiving 2000 to 5000 milligrams steroid in predonisolone base. These findings suggested that by increasing the amount of steroids, pituitary-adrenocortical function of old men were apt to be supressed earlier than that of young men, and the patients treated with quantity of predonisolone from 2000-5000 milligrams were situated namely in “transitional stage” to marked pituitary-adrenocortical disfunction.
    Urinary 17-OHCS response to first ACTH·Z injection in aged subjects were also lower than that in young men. When the patients had received continuous stimuli by ACTH·Z, most patients responded supernormal in urinary 17-OHCS levels. But the maximum urinary 17-OHCS levels following prolonged large quantity of corticosteroids administration were as half as that of small quantity administration of corticosteroids.
    From the investigations in cases treated with both steroid and ACTH·Z, if we want to withdraw patients from steroid by ACTH·Z injection, especially in the patients with prolonged large quantity of steroids, we had better administer ACTH·Z to them about 3 times a week for several months after withdrawal from steroid.
  • 小口 勝司, 小林 真一, 深田 潤, 佐藤 博紀, 菊池 隆一, 萩原 民郎, 高原 和享, 森 甫夫, 松井 律東
    1978 年 38 巻 3 号 p. 333-338
    発行日: 1978/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    犬血清, 肝臓および脳mitochondria MAOに対する種々重金属の影響を, 犬血清MAOの場合にはMcEwen法の改良法を, 犬肝臓および脳mitochondria MAOではWarburg検圧計を使用して測定し, 比較検討した.犬血清MAOに対して種々金属は, その濃度10mM付近で, HgCl2はほぼ完全に, K2Cr2O7およびNa2Cr2O7は約40%, CrCl3は約20%その活性を阻害した.HgCl2およびNa2Cr2O7の犬血清MAOに対する阻害作用の可逆性を透析法にて検討した結果, いずれもその作用は不可逆的であった.犬脳および肝臓MAOに対するCdCl2の影響はtyramineを基質にした場合, 10mM付近で肝臓MAOでは約20%, 脳MAOでは約40%の阻害が認められ, benzylamineを基質にした場合, 同濃度付近ではともに約25%の阻害が認められた.HgCl2の影響はtyramineを基質にした場合, 肝臓, 脳両臓器MAOはともに1mMで完全に阻害された.一方, CrCl3はいずれの基質を用いた場合も肝臓, 脳とも全く影響は認められなかった.Na2Cr2O7の犬肝臓, 脳MAO活性に対する影響はtyramineを基質とした場合, 脳では30mMで約55%の活性の増加が認められたが, 肝臓では逆に25%の阻害が認められた.benzylamineを基質とした場合, 同濃度において脳では50%のMAO活性の増加がみられ, 肝臓では30%の阻害がみられた.このことは脳と肝臓mitochondriaとではNa2Cr2O7に対して異なる態度を示すMAOが存在することが示唆された.
  • 馬場 博康, 宗近 宏次, 古賀 靖, 岩崎 統, 高橋 久男
    1978 年 38 巻 3 号 p. 339-340
    発行日: 1978/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    The typical radiological picture of ascariasis in the small intestine was demonstrated incidentally in a patient who came with abdominal tenderness.
    The small bowel follow through study after upper GI series is emphasized to be worth while on occassion.
  • 扇谷 浩文, 内田 俊彦, 筒井 廣明, 渥美 敬, 森下 益多朗, 石橋 祥男, 亀川 陸雄, 山口 修, 森 雄二郎, 福島 直, 新井 ...
    1978 年 38 巻 3 号 p. 341-344
    発行日: 1978/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    It is more than two years since our hospital was opened on July, 1975. At this time, we have made the statistical observations for the operated patients. Total number of the outpatients was 8128; 841 cases occupied about 10 % of them were the inpatients and 516 cases about 60 % of them were operated.
    On the classification of the parts, the operation for the lower limbs was occupied about 60%, and on that of the disease, the deformation of the hip joint was done about 16%. Injury was within 30%, and very rare in our hospital which have no emergency system. Regarding the fracture of bone, almost all cases were the precedent introduced by other hospital by which our hospital has been characterized.
  • 福島 淑子, 真田 聖子, 調所 広之
    1978 年 38 巻 3 号 p. 345-348
    発行日: 1978/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    The authous report the removal of epiglottic cyst of man, aged 46 and woman, aged 58 by oral aproach.
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