In order to clarify the mechanism of allergic reaction and anaphylactic shock due to the administration of antibiotics and to study the prophylactic measures for such conditions, studies were made on the relationship between this allergic reaction and cirulatory autonomic function. Out patients selected at random were inquired of their experienec in having allergic reaction due to antibiotics, or the symptoms of neurocirculatory asthenia, beriberi or allergic constitution, and also their blood pressures were measured. On many of them, morever, including both sensitive and non-sensitive patients, circulatory autonomic function tests such as cold pressor test, TEAB intravenous injection test, Aschner's test, Czermak-Hering's test, Martient's test, postural test, , postural ECG test, were performed.
The number of patients examined was 1, 057. Of these patients, 5 males (1.6% of the male patients) and 20 females (5.1% of the females patients) were found to have the experience of developing allergic reactions by taking antiotics, namely, 19 were sensitive to penicillin, 6 to streptomycin. Shock developed in one of them and in the 5 cases the reaction was severe close to develop shock.
When the findings of the 25 patients were compared with those of the non-sensitive patients, the former had more symptoms of neurocirculatory asthenia and showed the symptoms of beriberi and allergic constitution more frequently.
Out of the circulrtory autonomic function tests made, cold pressor test, Martinet's test, Ashner's test and postural ECG test were positive in the sensitive patients.
This study suggested the participation of circulatory autonomic unbalance to the development of allergic reactions against antibiotics. Symptoms of neurocirculatory asthenia and the findings of above mentioned circulatory autonomic function tests seem to be highly valuable for the prophylaxis of allergic reaction, especially of shock due to administration of antibiotics.
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