This study was projected for the purpose of obtaining the rate of utilization of alcohol's calories for daily muscular work. As the first step of this study, an experiment on the metabolism of alcohol was carried out.
Methods: As subjects, two males were selected as the middle or heavy drinker group (not alcoholics) and three males as the light drinker group. The experiment was made at fasting condition in the morning. The basal metabolism was determined at first, and then whisky containing 29.5g% of absolute alcohol was administered orally for a short time (two to ten minutes), being diluted to about 10% alcohol solution with water. Immediately after this the subject was lain in bed during the measurement-period of five hours. During this time the energy metabolism, pulse rate, body temperature and blood pressure were determined in every thirty minutes. The blood and urine were taken at intervals of half or an hour over eight or ten hours and these samples were analysed for alcohol concentration. The administration of alcohol were prescribed in dosages of 1.0g and 0.5g per kg body weight as absolute alcohol. The determination of alcohol was made on the basis of Gibson and Blonder's method.
The results were summarized as follows:
(1) The concentration of blood alcohol rised rapidly to a peak at thirty or sixty minutes after ingestion of alcohol in three subjects except one (subj. No. 2)in which a high concentration level was maintained constantly for about three hours after drinking and after that time the concentration curve of blood alcohol declined generally in a linear fashion. However, the concentration curve in 0.5g/kg alcohol intake appeared to be somewhat hyperbolic.
(2) The “β” factor was higher in the heavy drinker group with an average of 18mg% per hour than in the light drinker group with an average of 14mg% per hour, in case of 1.0g/kg alcohol intake. When a dosage of 0.5g/kg alcohol was administered to the light drinker group the “β” factor was 9mg% per hour in average, and this value was lower than that of the same individual in case of 1.0g/kg alcohol intake. The “γ” factor was in the range of 0.66 to 0.78 (mean 0.71) and this factor was found to be fairly constant in the same individual and to vary from individual to individual. “ED” value (ehtanol disappearance from blood, β×γ×body weight) in case of 1.0g/kg alcohol intake was higher in the heavy drinker group with an average of 7.5g (125mg per weight kg) per hour than the value of 5.8g (95mg per weight kg) observed in the light drinker group. In 0.5g/kg alcohol intake (in the light drinker group) this value was 4.0g (65mg per weight kg) per hour and this was about 30% lower than that of the same individual in the dosage of 1.0g/kg alcohol.
(3) The concentration of alcohol in urine declined in a linear form independently of the volume of urine being in agreement with the change of blood alcohol concentration. It seems that the ingested alcohol will be distributed equally throughout the body fluid after about an hour. However, the absolute amount of alcohol excretion per hour was influenced by the volume of urine. The maximum level of the hourly excretion of urine was seen at the initiatory period (within two hours after drinking) for three subjects, but for the other one (subject No. 2) was seen a peculiar type, i. e., the maximum level was at four or five hours after drinking.
(4) The heat production after drinking of 1.0g/kg alcohol showed a rise of only 4% above basal metabolism in a heavy drinker (subj. No. 2) and 13 to 14% in the light drinker group. In a smallest drinker (subj. No. 5) the metabolic rise reached up to 22% markedly in 0.5g/kg alcohol intake. Thus, the metabolic rise related to individual sensibility towards the pharmacological action of alcohol. This fact was also considered validly from the results that the degree of variations in pul
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