The influence of the stannous tartrate added diet feeding for the growth and maintenance of rats are examined. Less than 10mg% stannous tartrate in the diet, no influence. But from 55 to 110mg% stannous tartrate in the diet, caused serious interference, motorial hindrance on the hind legs, and at last someone fell dead.
Tin retention in the liver and the kidney of rat are did not detected by the polarographic analysis, when examined the viscera of adult rat breeding in long intervals (14 weeks) with a diet containing 110mg% of stannous tartrate.
An investigation are attempted about the change of intestinal flora of rat, by the taking of diet containing some stannous tartrate. The intestinal flora, used for this study, are selected of general intestinal flora of rat, such as Escherichia coli, Aerobacter, Streptococci and Clostridium type bacteria. The result are shown as follows. (1) In the case of breeding with the diet containing a stannous tartrate from 2mg% to 10mg%, the intestinal flora of rat did not occur any changes, however, according to the increasing of tin content (from 55mg% to 110mg% as stannous tartrate), a number of aerobe are decreased and the growth of Escherichia coli type bacteria are suffered. (2) In the medium containing stannous tartrate from 55mg% to 110mg%, the frequency of appearance of aerobe are decreased, and one of Escherichia coli type bacteria are markedly decreased also, compared with control medium.