We report of interferon-β (IFN-β) therapy with or without ribavirin in five patients with chronic hepatitis and mental disorder. Two of three patients diagnosed with depression and one of two patients diagnosed with chronic schizophrenic psychosis had developed a viral response after IFN-β therapy. Symptoms of depression or psychosis are well-known side effects of IFN-α therapy. Therefore, patients with mental disorders are often hesitant toward receiving interferon therapy. Direct acting antivirals (DAAs) will probably become mainstream therapy for IFN-α intolerant patients in the near future. However, the risk of developing mutations related to drug resistance should not be neglected. Therefore, experience with IFN-β therapy used as an alternative to DAAs is required.
Death coursed by liver cancer in Ibaraki Prefecture have been more than seven hundred people a year, and the fourth most common as malignant neoplasm. There have been no reports investigating the clinical status of liver cancer at the prefectural level in Ibaraki Prefecture. In order to understand the status of hepatocellular carcinoma in Ibaraki Prefecture, we underwent a hospital-based hepatocellular carcinoma surveillance. Actual status of treatment and its result of hepatocellular carcinoma was revealed. We are going to continue this investigation in the future.
Shear wave with Smart maps (SwSm) installed on Aplio500 developed by Toshiba Medical Systems Corp. allows us to estimate elasticity and visualize shear wave propagation by displaying contour lines of the shear wave arrival time. The usefulness of this device was compared with that of ACUSON (VTQ), Aixplorer (SWE), FibroScan (TE). Fifty-one patients who received liver biopsy, or diagnosed clinically as liver cirrhosis were studied. Correlation between the devices was evaluated in 142 patients who were assessed fibrosis by more than two devices. ROC analysis showed 0.950/0.943/0.913/0.923 in SwSm/VTQ/SWE/TE, respectively. Correlations between the devices were 0.853/0.956/0.885, in SwSm vs VTQ, SwSm vs SWE, SwSm vs TE, respectively. SwSm was superior to the other devices studied here in a non-invasive assessment of liver fibrosis. Moreover, Toshiba SwSm assures a reliable assessment by visualizing propagation of the shear waves.