1-Acetoxyethyl 2- (2 fluoro-4-biphenylyl) [14C-methyl] propionate (14C-Me-FP 83) (1), a novel nonsteroidal antiinflammatory agent for injection, was synthesized in order to investigate the metabolic fate. 14C-Me-FP83 was obtained by the condensation of 2- (2fuoro-4-biphenylyl) [14C-methyl] pro-pionic acid with 1-chloroethyl acetate. The chemical yield of 1 was 62% after purification. The specific activity was 258 kBq/mg (6.99, uCi/ mg) and its radiochemical purity was 99% in thin layer chromatographic method.
The radiation absorbed dose was estimated for131I therapy of metastatic lesions of thyroid cancer, by the quantitative gamma-camera imaging. Uptake for eleven lesions in five cases (out of four patients) was measured for two times after131I administration. Activities were calculated from opposed images with corrections for distance and depth using empirical formulae. An activity time curve was assumed as a reminder of two exponentials and fitted to measured values. The sizes of lesions were evaluated using the multi-slice CT images. An increase of frequency of activity measurement, particularly within a few days after131I administration is desirable, for the purpose of an improvement of accuracy of dosimetry.
The adsorption behavior of60Coon sand has been studied under various conditions. The amount of adsorption obeyed the Henry adsorption isotherm in concentration range of 10-14-10-10mmol/ml and the Freundlich adsorption isotherm in concentration range of 10-9-10-2mmol/ml. The distribution coefficient became to a maximum value under neutral region, but fell to a value less than 1- 2 order under acidic and alkaline region. The distribution coefficient measured under aerobic condition was larger than that under anaerobic condition in acidic region, but was smaller than that under anaerobic condition in alkaline region. The distribution coefficient measured at temperature of 10-50 °C was proportional to reciprocal temperature. Influence of co-existent ion was not observed in co-existent ion concentration less than 10-4mmol/ml, but was confirmed in coexistent ion concentration more than 10-3mmol/ ml.