The relation among the blood clearance of99mTc-phytate (99mTc-P), the hepatic uptake of99mTc-P and the severity of hepatic injury was investigated by using the rats with carbon tetrachloride (CCl4), D-galactosamine (Gal N), α-naphthylisothiocyanate (ANIT) or DL-ethionine (EthN) induced hepatic injury. After the administration of CCl4, GalN or ANIT, serum GPT activity increased significantly with the increase of dose level, and the degree of this increase was in the order: GalN>CCl4>ANIT. However, the mild increase in serum GPT activity was observed after EthN administration. The blood clearance rate of99mTc-P and the hepatic uptake ratio of 99mTc-P decreased with the increase of dose level after CCl4, GalN or ANIT administration, but significant changes were not found after EthN administration. The degree of decrease in the blood clearance rate of99mTc-P was in the order: GalN≅CCl4>ANIT, and the degree of decrease in the hepatic uptake ratio of99mTc-P was in the order: GalN≅CCl4>ANIT. These results suggest that the disorder in the hepatocytes may be one of causes for inducing the decrease in the hepatic uptake of99mTc-P, and the consequence of this decrease may induce the decrease in the blood clearance of99mTc-P.
Both67Ga citrate and201 Tl chloride accumulated in a parathyroid tumor of a 62 year-old woman with primary hyperparathyroidism. Histological studies disclosed that the tumor was a parathyroid carcinoma. The use of both tumor scanning agents, 67Ga citrate and201Tl chloride to visualize parathyroid carcinoma in a patient with primary hyperparathyroidism has not been reported as far as we could determine.