RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
63 巻 , 11 号
選択された号の論文の4件中1~4を表示しています
原著
  • Katsuyoshi TATENUMA, Koji ISHIKAWA, Akira TSUGUCHI, Yuko KOMATSUZAKI, ...
    2014 年 63 巻 11 号 p. 501-513
    発行日: 2014/11/15
    公開日: 2014/11/28
    ジャーナル オープンアクセス
    A new method to produce highly pure 99mTc of maximum 500Ci(1.85e+13Bq) per batch from a low specific activity 99Mo made from natural-Mo(n, γ) method is presented in this study.Authors developed a novel procedure to provide 99mTc of high specific activity and purity from 99Mo with a low specific activity obtained by the(n, γ) method. This process named TcMM(technetium master milker) with a new principle found out by the authors involves the selective adsorption of 99mTc onto an activated charcoal column, followed by an elution of 99mTc by warm alkaline solution, and final purification through an alumina column, which would be applicable to routine production of a large amounts of 99mTc from natMo(with 99Mo) within a short processing time and with a low cost.By the experiment using a high radioactivity of 99Mo of 1e+12Bq levels, a highly pure 99mTc free from natMo(with 99Mo) was obtained in a sterile saline solution within 30 - 50min. as the chemical form of 99mTcO4, and the average 99mTc milking rate repeated 10 times got 93.5% and the radiochemical purity of the range of 6N - 7N.In the labeling experiments using several radiopharmaceutical kits,99mTc collected from the TcMM process gave the target medicines in a highly radiochemical purity.As the result of investigating the disposition behaviors of the above-mentioned 99mTc-pharmaceuticals using small animals(mouse), 99mTc collected from TcMM gave the same result as it eluted from the conventional 99mTc generator.The findings in this study suggest that the present method using natural isotopic 98Mo(n, γ)99Mo reaction would constitute as an alternative to the Fission Method using HEU to provide 99mTc useful for clinical studies.
連載講座
福島周辺における空間線量率の測定と評価
メスバウアースペクトロメトリーの基礎と応用
  • 野村 貴美, 氏平 祐輔
    2014 年 63 巻 11 号 p. 531-558
    発行日: 2014/11/15
    公開日: 2014/11/28
    ジャーナル オープンアクセス
    鉄は鉄器時代から重要な基幹産業の材料になり,現在広く利用されている。鉄材料は環境にやさしい物質であるが大気中の腐食によって劣化もしやすい。鉄の酸化過程や鉄材料表面の腐食生成物の解明によってさびを防ぐための防食技術や表面改質技術が培われてきた。メスバウアー分光は,X線回折,オージェ電子分光,グロー放電発光分光又はラザフォード後方散乱の分析法を併用することによって多様な酸化物の状態や表面構造の分析法になる。鉄の酸化過程,酸化物やリン酸塩のメスバウアーパラメータとともに鉄鋼,ステンレス鋼,耐候性鋼板の酸化皮膜とリン酸塩処理などの防食皮膜のメスバウアー分光による解析例を紹介する。さらに応用として太陽電池のための酸化鉄膜やステンレス鋼の酸化皮膜のpHセンサーの応用についても述べる。
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