The comparative study of the blood clearance tests of 99mTc-phytate (99mTc-P) and indocyanine green (ICG) was undertaken in liver-injured rats with carbon tetrachloride (CCl4) . The blood clearances of 99mTc-P and ICG in rats decreased with the increase in dose of CCl4 and with the time elapsed after CC14 administration, As compared with the blood clearance test of ICG, the blood clearance test of99mTc-P in rats was found to be more sensitive in detection of the hepatic dysfunction with mildly damaged stage, but to be relatively inaccurate in detection of the hepatic dysfunction with severely damaged stage induced by CCl4.
The monitoring of urinary tritium was performed on eight radiation workers who handled3H-labeled compounds more than 37 MBq, Tritium was detected from a radiation worker who disposed of a non-volatile3H-labeled compound stored for nine and a half years after the last use. The observed effective half-life was 10.8±1.9 days. It was assumed that internal contamination was caused by inadvertent inhalation of tritiated water vapor, which might be produced by a degradation of the labeled compound. Radiation workers should be properly protected by taking into account the possibility of internal contamination when they deal with originally non-volatile3H-labeled compounds stored for a long period.