A substoichiometric radiochemical method has been developed for the determination of microgram amount of cobalt utilizifig potassium ethyl xanthate as a reagent. The effect of pH and the foreign ions on the substoichiometric extraction of its ethyl xant hate complex into chloroform was also studied. Microgram amounts of cobalt was determined with an average error of ±1.42%.
A substoichiometric radiochemical method has been developed for the determination of thallium (I) employing potassium ethyl xanthate as a reagent. The effect of pH and foreign ions on the substoichiometric extraction ofTl (I) ethyl xanthate complex into chloroform was studied. Tens of micrograms amount ofTl (I) was determined with an average error of ±1.35%.
Thyroid scintigraphy in rats and mice with99mTC and123I was attempted to examine whether this modality might be used in small animals and to describe the possibilities of its application in examing experimentally produced thyroid diseases. A human gamma camera with a pinhole collimator improved for small animals was used for imaging. Thyroid images with99mTc were obtained 20 minutes after injection and those with123I were 24 hours after administration. All the scintigrams, although those obtained from mice with99mTc displayed overlapped salivary gland images, demonstrated sufficiently clear images in size and shape, which showed that thyroid scintigraphy in small animals should be applicable in examining experimentally produced thyroid disases.
The biodistribution of nanometer-sized colloidal particles (nanocolloids, Solco-Basle Ltd.) was examined in six rabbits with turpentineinduced abscesses in the masculature of their hind legs. A 99mTc labelled colloids with a mean particle size less than 100nm were administered to each rabbit intravenously. The biodistribution of the tracer was studied with a gamma camera 1, 3, and 24 hours after injection. Prominent uptakes were demonstrated in the liver, spleen, bone marrow, kidneys, and urinary bladder. On the other hand, the abscess and surrounding inflammatory edema was depicted as unclearly margined faint hot spot. Subsequently, the rabbits were sacrificed and activity per gram tissues were counted with a well-type gamma counter. Although the results were almost in agreement with a gamma camera study, it was noticed the activity counts in the abscess was significantly higher than that of control muscle.