Accumulation of99mTc-MIBI has been reported in several various carcinomas. In this study, 99mTc-MIBI scintigraphy was evaluated to detect recurrent or metastatic lesion in seven patients with thyroid carcinoma. The results were compared with those of131I scintigraphy and201T1 scintigraphy. Bone metastasis and lymphnode metastasis were well demonstrated in99mTc-MIBI scintigraphy, but131I scintigraphy allows the best visualization of pulmonary metastasis. 99mTc-MIBI scintigraphy has desirable characteristics including the potential for no thyroid hormone withdrawal, immediate imaging postinjection, and low radiation burden. In conclusion, it is shown that99mTc-MIBI scintigraphy is a useful procedure in follow-up of thyroid carcinoma and has the potential for visualization of metastasis when131I was negative.