We report the result of immunoscintigraphy by using IMACIS-1, which consists of 131I-labelled F (ab') 2fragments of monoclonal antibodies to anti-carcinoembryonic antigen (CEA) and anti-CA19-9. All of seven patients entered in this study were suffering from malignant diseases with elevated serum levels of CEA or CA19-9. Positive findings were obtained in two patients: One case was suffering from cholangiocarcinoma and the other from metastatic liver tumor due to colon cancer. In both cases, the diameter of the tumor was more than 3cm. Interestingly, in the latter case, the accumulation of IMACIS-1 was not seen in the coexistent hypopharyngeal cancer. Accordingly, despite the limited number of patients, IMACIS-1 was thought to he worth trying in detecting CEA-or CA19-9-producing malignancies or making differential diagnosis of them from the coexistent independent tumors.
99mTc-Galactosyl human serum albumin (99mTc-GSA) is a new liver imaging radiopharmaceutical which specifically binds to the asialoglycoprotein-receptor on the liver cell membrane. We investigated the usefulness of99mTc-GSA for evaluation of the liver function in patients with chronic liver damage. We calculated LHL15 for the index of hepatic uptake and HH15 for the index of clearance. In patients with liver cirrhosis, LHL15 value was higher and HH15 value was lower than those of other groups. Both decrease in LHL15 value and increase in HH15 value were correlated with the severity of the liver damage. Significant correlation was also observed between the prolongation of ICG clearance and both decrease in LHL15 value and increase in HH15 value. In conclusion, these findings indicate that 99mTc-GSA can be a useful agent for evaluation of the liver function in patients with chronic liver damage.