Sulfisomezole (SZ) in three forms, injection, paste, and syrup, was administered orally and parenter ally (subcutaneous injection) to neonatal and sucking piglets within 3 weeks of age at a dose of 100mg per kg of body weight. Then the concentration of SZ in the blood was determined.
1. The blood level of SZ was higher in the newborn than in the suckling about 3 weeks old when the drug had been administered by both routes.
2. The blood level of N1 acetylsulfisomezole (AS) given in paste form was higher than that of SZ given in syrup form.
3. Results were somewhat variable with the litter or individual. The decreasing order of the average blood level of the drug, however, can be given as folllows: newborn (SZ, injection), newborn (AS, paste), suckling (SZ, injection), suckling (AS, paste), suckling (SZ, syrup).
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