Two dairy cows were affected with general amyloidosis, showing emaciation, anemia, edema, cessation of milk secretion, and absence of estrus. Hepatomegaly of milk secretion, and absence of estrus. Hepatomegaly was confirmed by biopsy in one of them. No pictures were present to indicate the regeneration of erythrocytes. Remarkable proteinuria was characteristic of both cows.
Hypoproteinemia was observed. Paperelectrophoretic analysis revealed a decrease of albumin and an increase of α- and β-globulin, particularly γ-globulin. It also proved that not only albumin but also globulin appeared in the urine.
In the etiological consideration, it was presumed that these cases might be related to Johne's disease.

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In the past four years, some cases of toxoplasmosis were detected from among those slaughtered at the Yawatahama Meat Packing Center in Ehime Prefecture, Shikoku. The etiologic organism was harbored in many organs, causing infiltrations of lymphocytes, lymphoid cells, and macrophages. It was difficult to find out any chronic case of this disease.

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A female bovine fetus with many deformities on the head and face was obtained at the Hanyu Slaughter house. It was 77 cm in crown-rump length and 31kg in body weight. Dissection of it gave the following findings.
(1) The deformities observed were cyclopia, agenesis of nose, formation of a proboscis, astomia, synotia, agnathia, anencephalus, and hydrocephalus.(2) The single median orbit contained an eyeball of normal size, but neither optic nerve nor retina was seen.(3) The proboscis, formed under the orbit, was covered with skin which had hairs outside and outer loose and inner fatty connective tissues inside. It contained no nasal tube.(4) In spite of astomia, there was a small oral cavity, which contained a rudimentary tongue, and a pharyngeal cavity, which was divided from the oral cavity by lateral folds.(5) The right and left ears were displaced downwards. Each of them had an external auditory canal and a fused tympanic cavity. A wide eustachian tube opened to this cavity from the dorsal wall of the pharynx.(6) No cerebrum nor greater part of the diencephalon was seen. The other parts of the brain-stem, except a smaller part of the diencephalon and the cerebellum, appeared to be well-formed. A wide opening of the sylvian aqueduct was blown out into a thin-walled hydrocephalic sac containing abundant cerebrospinal liquid.(7) The cranial bones, especially some anterior ones, were very abnormal in composition and shape due to the deformities described above. No mandible was seen.(8) Much liquor was contained in the stomach.

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Two 2-year-old hybrid Holstein-Friesian cows were found to be suffering from porphyria, or porphyrinopathy. They were very thin, showing retarded growth. They had teeth of filthy pink color, and excreted urine of light reddish-brown color. Their skin was normal. Anemia was pronounced and few erythrocytes were normal during the hot summer season. With the dissipation of summer heat and the shortening of daytime, there was a decrease in amount of excretion of porphyrin, and general conditions of health were improved with the appearance of normal erythrocytes.
Autopsy findings consisted of bone tissue of reddishbrown color, decrease in amount of bone tissue as a result of enlargement of the bone-marrow cavity, softening of bone marrow, and enlargement of the spleen. Bone tissue gave rise to a bright-red fluorescence when irradiated with ultraviolet rays.

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A survey was conducted on three herds, A, B, and C, of dairy cows in the suburbs of a city in Saitama Prefecture to clarify any relationship between feeding conditions and blood constituents.
In the survey on feeding conditions, DM was short in herd A all the year round, in herd B in spring and autumn, and in herd C in winter. DCP was generally too much, although it was optimum in A and C in winter. TDN was generally optimum, although it was too much in A in summer and autumn. DCP/TDN was optimum in A all the year round, but too high in the other herds in all the seasons, except winter.
In the hematological survey, NPN was almost normal in A in all the seasons, except winter, but always high in the other herds. UN was normal in A in all the seasons, except winter, always high in B, and high in C in all the seasons, but winter. UN/NPN was low in summer and high in winter in A and always high in the other herds. T. Ch was always normal in A and high in B in all the seasons, except summer, and in C all the year round. TP was always normal in A and B, but high in C in spring and autumn. A/G was always normal in A, but low in B in summer and in C in the four seasons. BS was normal in the three herds.

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