Four 36 per cent and one 90 per cent preparations of methyridine (MR) were tested for side effect on 10 dogs. A dose of each preparation containing 36 mg/kg of effective component was injected subcutaneously at five different sites on the lateral side of the thigh of both legs, a dog receiving a total dose of 180 mg/kg. As a result, only transitory general symptoms and a slight reaction at the site of injection were noticed. There was no increase in toxicity of MR when this drug was applied simultaneously with one of eleven different anthelmintics.
It was concluded that a dose of 0.1 ml/kg (containing 36 mg/kg of effective component) of a 36 per cent preparation of MR to which had been added hydrochlorate of dibucain alone was destructive to canine whipworm when injected subcutaneously on the lateral side of the thigh.

View full abstract

A total of 119, 721 head of swine were examined in slaughterhouses in Saitama Prefecture over a tenmonth period ending in March, 1966.Of them, 122 were diagnosed as cases of toxoplasmosis at postmortem examination.Protozoa were detected from 95. The changes most frequently observed were petechiasis andedema of the lung, cloudy swelling of the liver, and swelling and hemorrhage of lymph nodes at the gastric, hepatic, and pulmonary hilus.The rate of protozoal detection was the highest in the lymph node at the gastric hilus, which was followed by that at the hepatic hilus.It was high in November, December, and January.
The results of intradermal tests were compared with the protozoal detection by the fluorescent antibody technique.The rate of protozoal detection was very high in animals which had given suspected intradermal tests.Protozoa were detected even from animals giving negative intradermal tests.

View full abstract

Fifty-day-old chickens were administered with 0.2 per cent (group A), 0.4 per cent (group B), and 1.0 per cent (group C) of sulfadimethoxine mixed with a diet. In groups B and C, medication was continued for 30 days. In group A, consecutive 3 or 4 days' medication was alternated with a 2 or 3 days' recess.
Feed intake was reduced with an increase in the additive. In groups B and C occurred diarrhea and soft feces. Many chickens of these groups manifested anemia and weakness about 10 days after medication, showing 27 per cent the rate of increase of body weight among the control ones.
The average serum level of the drug in total and in free amount was 19 and 14 mg, respectively, in groupB and 30 and 26 mg in group C.
Autopsy revealed hemorrhagic changes in groups B and C on and after the 15th day after medication. They seemed to have been induced by vitamin K deficiency, which might have been caused indirectly by the long-term medication.
Neither hematological nor histological examination proved any noticeable toxicity of the drug.

View full abstract

Almost all the native cattle grazing in the municipal pasture in Suzu, Ishikawa Prefecture, were involved in outbreaks of type III parainfluenza in 1964, 1965, and 1966. Of about 300 cattle infected, fifteen were fatal or condemned.
After an incubation period of 10 to 15 days, the animals manifested a fever (39-41°C), coughing, white nasal discharge, anorexia, filthy conjunctivae, and diarrhea. Moist rale was heard in the serious case. Red blood count was 6-15 millions and white blood count 4-10 thousand. Lymphocytosis occurred. Autopsy revealed catarrhal and suppurative broncho-pneumonia, hepatic parenchymatitis, and hemorrhages of various parenchymatous organs. The course of disease lasted more than a month. No dissipation of fever was seen in the serious casefor several months.
Gram-negative bacilli of small size were isolated from lesions of pneumonia. Serological examination established a diagnosis of shipping fever to which parainfluenza virus type III had been related. Sulfa drugs and antibiotics were effective to alleviate the symptoms.

View full abstract