A dark-red fragile neoplasm of thumb-tip size was found in the clitoridean dipression in a 4-year-old bitch of a indigenous Japanese breed which had been bleeding from the vulva since about a month before. The bitch manifested anorexia, depression, rise in body temperature, frequent dry coughing, moderate anemia and leukocytosis, and shift to the left of nuclei.
Cytological diagnosis of malignant tumor was made and oncotomy performed. Since there was no amelioration in the general conditions, cytological examination of hydrothoracic sediments, chest x-ray examinaion, electrocardiography, and exploratory thoracotomy were carried out. As a result, it was confirmed that there was distinct metastasis of the tumor in the thoracic cavity. With bad prognosis, the bitch was subjected to euthanasia.
Histopathological examination revealed that the tumor was hemangiosarcoma originally produced in the vena dorsalis clitoridis. Few cases of this tumor had been reported in Japan.

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Four “miniature” piglets were fed a commercial complete combined diet to which had been added 0.55×0.60 ppm of aflatoxin B₁ for 122 consecutive days. They showed transitory anorexia and discharge of hard feces, and a slight delay in growth. At autopsy, liver, spleen, and kidney increased in weight. The liver was enlarged and faded a little.
Histopathologically, the liver was affected with early formation of pseudolobules, enlarged lobules, deposition of brownish yellow pigment in hepatic cells and sinusoids, central or fascicular necrosis of lobules, inequality in size of hepatic cells, appearance of cells with a large nucleus, thickening of interstitial tissue, septal formation, hyperplasia of bile ducts, and formation of pseudobile ducts. In addition, cells with a large nucleus appeared in the epithelia of uriniferous tubeles and ovarian follicles underwent cystic degeneration.
From these results it was presumed that the present collective outbreak of hepatic cirrhosis in Saitama Prefecture might have been caused by feeding a diet containing aflatoxin produced by Astergillus flavus.

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In a basic experiment, 8 cows were given 3, 000 larvae of bovine lung worm by the oral route and, 21 days later, treated with dl-tetramisole. They showed resistance to reinfection when challenged with 3.000 larvae 81 days after the initial infection.
Field experiments were carried out four times. In the last experiment, cattle positive for larvae in feces were medicated twice with the agent at a 40 day interval in spring. As a result, there was no increase in the number of positive cattle on the same pasture in autumn. Moreover, only mild symptoms were manifested by the infected animals. Therefore, tetramisole was demonstrated to have anthelmintic ad preventive effects against bovine lung worms.

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