An 8-year-old Holstein cow imported from the United States 6 years ago manifested such clinical symptoms as suggestive of traumatic pericarditis. Hematological examination revealed a progressive increase in the leukocyte count and the appearance of atypical lymphocytes. The cow lost weight and became weak, so it was sacrificed with a bad prognosis. Postmortem examination revealed remarkable swelling of lympn nodes, especially cervical, thoracic, and iliac, and tumorous lesions in the heart, kidneys, pancreas, and uterus. Histopathologically, the lesions of the lymph nodes were characterized by neoplastic proliferation of lymphoid cells, with reticuloendothelial cells mixed. The tumors of the other organs were composed of essentially the same neoplastic cells as those of the lymph nodes.
Upon 42 calves experimentally infected and 63 calves naturally infected with the lungworm, Dictyocaulus viviparus, the effects of both oral and intramusscular administration with dl- and l-tetramisole were examinaed. The high anthelmintic activity of tetramisole was revealed on lungworms more than 14 days of age. The efficacy of 12.5-15mg/kg of dl-tetramisole was equal to that of 7.5mg/kg of l-tetramisole. The efficacy did not differ between the two routes of administration. It included satisfactory body weight gain and alleviation of pneumonia.
Bacteriological studies were performed on 307 porcine and 20 bovine cases of endocarditis detected at the Municipal Abattoir of Osaka over a period from 1967 to 1972. 1. Bacteria were detected from 258 porcine and 12 bovine cases. Streptococcus and Erysipelothrix insidiosa were isolated from 114 and 83 porcine cases, respectively. Streptococcus was isolated from 6 and Corynebacterium pyogenes from another 6 bovine cases. 2. Lesions of endocarditis were frequently observed in the left heart (54.4%) in the porcine cases and in the right heart (50.0%) in the bovine cases. They were prevalent in the auriculoventricular valve in both cases. 3. E. insidiosa was isolated frequently from lesions of the bicuspid valve. There was no significant difference in the rate of detection of Streptococcus between the right and left heart in the porcine cases. 4. The bacterial species isolated from lesions of endocarditis were detected from the liver, kidney, and spleen of the same cases at a high frequency. The bacterial species isolated from at least one of these organs were detected frequently from the carcase of the same cases.