Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Volume 68 , Issue 6
Showing 1-4 articles out of 4 articles from the selected issue
Farm Animal Medicine and Animal Health
  • Kazuyoshi HASHIZUME
    Type: Review
    2015 Volume 68 Issue 6 Pages 367-378
    Published: June 20, 2015
    Released: July 20, 2015
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  • Hajime KATO, Shigeru NAKAO, Futoshi NAKADA, Reiichiro SATO, Mamoru OON ...
    Type: Original Article
    2015 Volume 68 Issue 6 Pages 379-383
    Published: June 20, 2015
    Released: July 20, 2015
    Eight healthy Holstein dairy cows were inoculated with an inactivated bovine salmonellosis vaccine that was composed primarily of inactivated somatic antigens of Salmonella typhimurium and Salmonella enterica serovar Dublin and contained polymixin B sulfate, an endotoxin neutralizer. Clinicopathologic responses were observed. After vaccination, neither a decline in appetite nor deterioration in their general condition was noted. Swelling and induration were recognized at the inoculation site. A hematological examination revealed significant post-vaccination changes in the hematocrit, albumin-to-globulin ratio, total protein concentration, aspartate aminotransferase activity, creatine kinase activity and sialic acid concentration in the serum, all of which are markers of acute inflammation. However, no clinical manifestations suggestive of endotoxic shock or anaphylactoid reaction were noted after the vaccination. Although this vaccine causes local acute inflammation at the inoculation site, the likelihood of severe side-effects is low. Therefore, the vaccine can be used effectively in clinical settings.
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Small Animal Medicine
Veterinary Public Health, Wildlife and Environmental Conservation