When healthy dogs were kept in the same cage with a dog suffering from dermatophytosis caused byM. canisorT. mentagrophytes, they were readily infected. However, when they were administered with griseofulvin, they were protected from infection. When 5 dogs were kept in the same cage with a dog infected withM. gypseum, only one of them acquired the infection. When the skin surface of experimental dogs was injured by clipping and injection obvious lesions appeared at the site of injury.
On a farm in Hokkaido, 13 sheep were affected with chronic copper poisoning over a period of 1975 to 1977. They manifested sudden depression and anorexia, anemia, jaundice, and hemoglobinuria to die after a course of 1-7 days. Biochemical tests gave results indicating the presence of high dysfunction of liver and kidney. The copper contents of serum, liver, and kidney were about 10.3, 4.8, and 14.9 times, respectively, as large as those of normal sheep. Histopathological examination revealed centralized or diffuse pimelosis accompanied with incomplete necrosis, severe biliary stagnation, and serious nephrotic changes. The causes of poisoning seemed to consist in pasture grass and litter contaminated with copper sulfate used for medicated foot bath.
When an antibody survey was conducted in October, 1976, 20 swine on a farm were negative for antibody against influenza virus. When 40 swine were examined in 5 areas in July and September, 1977, two of them showed a titer of 1: 128 and 1: 512, respectively, in one area. When 244 swine were surveyed upon arrival at the abattoir from 16 areas in November, 1977, the positive rate of antibody was 100% for those from 5 areas, 30%, 25%, and 15% from one area each, and 0% from 8 areas.
Seven cytopathogenic viruses and eleven bovine hemagglutination viruses were isolated from cattle in six outbreaks of respiratory disease in Hiroshima Prefecture over a period from 1974 to 1977. The former were neutralized with antiserum against the M-17 strain of bovine rhinovirus type 1. One (50-248-1 strain) of them was readily inactivated by acid, trypsin, and heating at 50°C for 60 minutes, but resisted ether and chloroform. The type of nucleic acid of the virus was determined to be RNA. The hemagglutinating properties of ten of the eleven bovine hemagglutination viruses were inhibited by antiserum against parainfluenza virus type 3 (PI-3). Cattle involved in the outbreaks showed fever, coughing, nasal secretion, and so on. A significant rise in antibody titer was shown at the same time against bovine rhinovirus, PI-3, and bovine adenovirus type 7 (BAd-7) in two cattle involved in the six outbreaks. Antibody titers were shown against bovine rhinovirus, bovine respiratory syncytial virus (BRS), PI-3, and BAd-7 in two cases, and against bovine rhinovirus, BRS, and BAd-7 in two cases. An antibody titer against bovine rhinovirus was noticed in 86% of the serum samples collected from cattle in Hiroshima Prefecture.
The diagnosis of bovine demodectic mange was made on 7 cattle in a district with about 900 cattle raised over a period from March to September, 1977. Some agents containing organic phosphorus were effective for destroyingDemodex bovisStiles, 1892 within about 2 weeks. It took about 2 months, however, for nodules produced on the skin to disappear. No cases were seen in or after October.