Diethylcarbamazine (proprietary name: supatonin) was tested for anthelmintic effect on Metastrongylus by administering it to repeatedly infected experimental cases in the early stage of infection. The following results were obtained.
1. In the first experiment, treatment was started 14days (in groups A, B and C), 18days (in group D), and 21days (in group E) after the first infection with metacercariae of Metastrongylus. The deworming rate was 93 per cent in group A (treated with 5 courses at intervals of 13 days, each course consisting of 3 daily doses of 100mg/kg each given every other day), 88 per cent in group B (treated in the same manner as group A, except the daily dose which was 150mg/kg), 91 per cent in group C (treated in the same manner as group A, except that each course consisted of 5 daily doses of 100mg/kg each given for as many consecutive days), 98 per cent in group D (treated with 4 courses at intervals of 17 days, each course being the same as in group C), and 93 per cent in group E (treated in the same manner as in group D, except an interval between courses which was 20days). It was 93 per cent on the average in the 5 groups.
2. A second experiment was carried out to co nfirm the most excellent results in the preceding experiment that had been given by group D. As a result, it revealed a similar deworming rate of 94.5 per cent.
3. No anthelmintic effect of the drug was proved in group F in which treatment was started 25 days after infection with metacercariae when the worms began to ovulate.
View full abstract