Dogs were anesthetized with 2mg/kg of xylasin (XN) and 10mg/kg of ketamine hydrochloride (KH) by two methods. In one method XN was injected intramuscularly and KH 15 minutes later (group I). In the other method XN and KH were mixed in the syringe and injected intramuscularly (group II). In both groups anesthesia lasted for 30-45 minutes after essentially the same lapse of time. Emesis occurred to 50% of the dogs of group I soon after injection with XN and to 30% of those of group II several minutes after injection with the mixture. In both groups bradycardia was prevented by preliminary treatment with atropine sulfate. Body temperature decreased by about 1°C. Average femoral arterial pressure increased by 21% in group 115 minutes after injection with XN and by 24% in group II 15 minutes after injection with the mixture. The respiration seemed to have been inhibited only mildly. No marked changes were observed in the blood test in either group. Both methods were concluded to be used effectively for anesthesia in dogs.
Five breeding indigenous Japanese cows with clinical symptoms of liponecrosis were administered with 250g of yokuinin, or a main component of the graminoid grass, Coix ma-yuen, for 2 consecutive days. This treatment was carried out 4-5 times at twoweek intervals. As a result, there was a reduction in the size of necrotic mass. Five cows with subclinical liponecrosis were administered orally with a daily dose of 250g of the grminoid grass powder for 6 consecutive months. As a result, necrotic masses around the rectum decreased in size or disappeared in months.
Sulfamonomethoxine (SMX) residues at the site of intramuscular (i.m.) injection in cattle and swine were pharmacokinetically estimated from blood concentration-time curves. Availability of SMX after i. m. injection was evaluated to be about 1 in both animal species. The rate of absorption expressed as half life was estimated to be 13.8 minutes for cattle and 26.6 minutes for swine. These results suggested that the residual concentration of SMX at the site of i.m. injection might be below 0.1 ppm within 10hours.
Mesothelioma of the pleura was found in a male southern elephant seal, Mirounga leonina. It was a localized flat mass (60×60×8cm, 18.0kg) in the left pleural cavity filled with massive bloody effusion. The parietal pleura was thickened and nodular. Microscopically, the tumor was made of papillary projections lined with cuboidal or columnar cells with admixture of sarcomatous proliferation of spindleshaped tumor cells. Histochemical studies revealed. that the tumor cells had produced acid mucopolysaccharide digestible with hyaluronidase. There was no distant metastasis or involvement of any otherbody cavity. Histological diagnosis was localized. papillary mesothelioma. The animal died of massive hemothorax. Mesotheliomas have occurred in human beings, cows, horses, dogs, cats, hamsters, rats, and buffalos and experimentally in squirrel monkeys, but are very rare among wild animals.