The effects of Promintic, an injection formula of methyridine, on swine nematodes were evaluated in field trials involving 106 swine. In the case of Trichuris suis, excellent results were obtained with a dose of 100 mg/kg, which is lower than the effective dose reported in the preceding paper. In addition, nearly comparable efficacy was confirmed with so low a dose of 50 mg/kg. In the case of Strongyloides ransomi, the effective dose level of 150mg/kg, as reported in the preceding paper, was able to be substantiated. As shown in the preceding paper, however, the efficacy against Ascaris suum was low, and little efficacy was proved against Oesophagostomum spp. A markedly reduced egg count of Metastrongylus apri was observed with a dose of 250mg/kg or higher, as shown in natural cases in the preceding paper. When a dose of 300 mg/kg or lower, as divided into two equal aliquots, was injected subcutaneously at the areas posterior to both ears, the resulting systemic and local reactions were mild in general.
Collective food poisoning broke out among workers of several plants who ate box lunch supplied by a caterer. The lunch contained bacon made of whale meat, mackerel, and natto, or fermented soybeans. These kinds of food were incriminated, and enteritic vibriones isolated from them. These organisms were divided into more than six types, including serotypes O-4: K-9 and O-2: K-3 of biotype I. SOince the whale bacon had not been heated, it was presumed to have carried these organism to the lunch and contaminated the fish and beans.
Two outbreaks of presumable avian encephalomyelitis occurred among young chicks in Okayama and Wakayama Prefectures. The following observations were made. 1. Intracerebral passages of brain materials collected from both outbreaks were performed with success. The inoculated young chicks showed the marked clinical manifestations of paraplegia and tremor. 2. Histopathological examination of 5 field and 55 experimental cases indicated non-purulent polioencephalomyelitis, i.e., neuronal degeneration characterized by central chromatolysis, perivascular cuffing and glial proliferation, which had a close resemblance to that of avian encephalomyelitis.