We investigated the development of lung lesions in primary specific pathogen-free pigs inoculated with either
Mycoplasma hyopneumoniae or
Pasteurella multocida or with both. Then we evaluated
M. hyopneumoniae vaccine in cases of dual infection with
M. hyopneumoniae and
P. multocida. In pigs inoculated with
P. multocida alone, no pulmonary lesions were observed, and organisms were rapidly eliminated from the lungs. Moderate pulmonary lesions were observed in pigs inoculated with
M. hyopneumoniae alone. Severe, extensive pulmonary lesions were observed in and organisms were isolated from pigs inoculated with both
M. hyopneumoniae and
P. multocida. These results suggest that
P. multocid a infection aggravates the severity of lung lesions caused in pigs by
M. hyopneumoniae infection. The
M. hyopneumoniae inactivated vaccine proved effective against not only
M. hyopneumoniae, but also dual infection with
M. hyopneumoniae and
P. multocida.
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