Changes of serum a-fetoprotein (AFP), GOT and GPT levels after carbon tetrachloride (CC1
4) administration were studied in young dogs, in which the ability to produce AFP still remained, and adult dogs, in which this ability was reduced.
The serum AFP level increased after a single dose of CC1
4 in both young and adult dogs. The maximum level of AFP was about seven times as high as the initial level in the adult dogs and about two times in the young dogs. The increase of serum transaminase activity was higher in the young than in the adult dogs.
The increased serum AFP level following CC1
4 administration returned to the initial level in about 35 days in the young and in more than 45 days in the adult dogs.
In both increase and recovery of serum AFP level following CC1
4 treatment, a lag of some days was observed, as compared with those of serum transaminase activity.
The extent of increase was smaller in serum AFP level than in serum transaminase activity following CC1
4 treatment.
The increase in AFP production following CC14 administration in dogs might be due to activation of a mechanism which was different from that existing in embryonic life.
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