Morbidity of bacterial endocarditis was surveyed among swine handled at an abattoir in Nagoya during the past two years. This is only one case of endocarditis from which organisms regarded as staphylococci were isolated. In addition to the lesion of endocarditis, cardiac muscle, lung, liver, spleen, kidney, and some skeletal muscles harbored staphylococci of essentially the same property. The autopsy findings of the present case were very similar to those of the case of swine erysipelas of endocarditis type and the case of porcine endocarditis from which streptococci had been isolated.
pneumoencephalitis was induced in 57-day-old and 1-day-old chicks by means of single intracerebral IC and intra-aerosaccular IA inoculation with the TCND strain of Newcastle disease virus. Severe nervous symptoms, such as leg weakness, paralysis, tremor, and depression, were found in the IC groups at both ages. Some 1-day-old chicks of these groups died 5 or 6 days postinoculation. No respiratory symptoms were seen any group. Lesions in the central nervous system were the most prominent in the 57-day-old IC group of the four inoculated ones. They were characterized by disseminated nonpurulent encephalomyelitis and composed of nerve cell degeneration, glial proliferation, and perivascular cell infiltration. The 1-day-old IC group, however, showed only mild lesions, in spite of severe nervous symptoms. Changes in the respiratory tract, such as peribronchial lymphoid cell infiltration, necrosis of infiltrating lymphoid cells, and septal pneumonia-like feature, were found in the 4 groups, except the 1-day-old IC group. Of the other organs, the bursa of Fabricius showed interesting changes which were composed of necrosis and the disappearance of follicular lymphoid cells. Simultaneously, reticuloendothelial cells supporting the follicles began to proliferate, and necrotic lymphoid cells were replaced.
Studies were made to clarify the effect of estrogenic substances contained in leguminous grasses on bovine fertility in the Nemuro district, Hokkaido. In experiment 1, several kinds of pasture grasses were tested for estrogenic activity by the mouse intravaginal method. In experiment 2, three Holstein cows were grazed on a pasture with a high ratio of leguminous grasses during the first few months after delivery. Three control, Holstein cows were grazed on a pasture with a low ratio of leguminous grasses during the same period. The levels of free estrogens and eosinophilic cell count were examined in blood samples taken from these cows at regular intervals. Endometrial biopsy was also conducted. The results obtained are summarized as follows. 1. The estrogenic activity was detected from red clover and ladino clover, showing maximum at the full bloom stage. It was not found in timothy or orchard grass. 2. During the first few months after delivery, no significant difference was present between the control and experimental cow groups in the levels of free estrogens in blood specimens concentrated about 40 times or in chaneges of eosinophilic cell count. 3. The average interval from delivery to the first estrus was 69 days among the experimental cows and 62 days among the control cows. 4. No cystic hyperplasia of the endometrium or other pathological change of the uterus were observed in biopsy specimens collected from the experimental cows.