[in Japanese]

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Four Preparations, dictycide, cyanacetohydrazide (CAH), acetylcyanacetohydrazide (ACAH), and the filaricide diethylcarbamazine DC; supatonin, a proprietary product, were examined for anthelmintic effect upon swine lung worms, by using 18 artificially and 7 naturally infected pigs. CAH and ACAH had been synthesized in Japan. When a dose of 30 or 40mg/kg of dictycide was injected subcutaneously for three days, excretion of eggs was reduced temporarily. This drug gave an average anthelmintic rate of 35.5 per cent. C AH and ACAH was essentially the same in destructive effect as dictycide. An anthelmintic rate of 48.0 per cent was obtained when a dose of 150mg/kg of DC was given per os for eight days.
When a dose of 50mg/kg of DC and a dose of 30mg/kg of ACAH were injected simultaneously by the intramuscular and subcutaneous route for five and three days, respectively, the rate of egg reduction was 96. 0 per cent and the anthelmintic rate 99.0 per cent.
No remarkable results were given by CAH. An anthelmintic rate of 86.0 to 97.0 per cent was shown by DC on guinea pigs experimentally infected with lung worms. DC exhibited, however, an anthelmintic rate of as low as 48. 0 per cent on swine infected with lung worms. Simultaneous injection of DC and ACAH was so effective as to reveal an anthelmintic rate of 99.0 per cent when applied to infected swine.
When a pig was injected with a dose of 75mg/kg of CAH, such symptoms of intoxication as described by Walley were apparent in it. They disappeared after injection with vitamin B₆.
Besides, large eggs, 48.5-59.1×65.1-76.9 microns, were excreted in the feces after medication of these preparations.

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A total of 91 serum samples from suckling piglets and 14 colostric serum samples from mother sows were examined for protein contents by means of paper electrophoresis. The results obtained are summarized as follows.
A. Serum protein of piglets.
1. Immediately after birth.(See table)
2. Twelve hours after the beginning of suckling.(See table)
3. The albumin/globulin ratio was the highest in suckling piglets at four weeks of age, when the ratio was 1.14±0.47.
B. Colostric serum protein. The paper-electrophoretic pattern of colostric serum protein was divided into four peaks according to mobility. The fourth peak showed a value of 66.06±7.69 per cent immediately after parturition. It seemed that this peak might be related to gamma-globulin of the serum protein of piglets.

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