Excessive salivation, erosion of the hard palate, and ulcers on the tongue were observed in a four-month-old Japanese black calf that was suspected of having foot-and-mouth disease (FMD). Although FMD was ruled out due to the clinical lesions and epidemiological status over the next two weeks, lesions were observed in ten other calves, ranging from four to seven months in age, at the same farm as well. The lesions included reddening, erythema, papules, erosions, and ulcers in the mouth. Using PCR, bovine papular stomatitis virus (BPSV) was detected in the oral swab samples from eight of the ten affected calves. The nucleotide sequences of the partial envelope gene were identical for all eight samples, and similar to those of the BPSV isolated in Japan. In addition, seroconversion against BPSV was observed in four of the ten affected calves. Based on these results, we diagnosed this as a case of BPSV infection with different types of lesions.

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A total of 20 dogs underwent conventional open ovariohysterectomy (OO, n＝10) and laparoscopic ovariohysterectomy (LO, n＝10). The number of leukocytes as well as serum c-reactive protein (CRP) and interleukin‐6 (IL‐6) concentrations were measured at 3 hours, 6 hours, 1 day, 3 days and 5 days postoperatively. Significantly lower serum CRP and IL‐6 concentrations and leukocyte numbers were seen at 1 day postoperatively in the LO group than in the OO group. There was no significant difference in surgical time between the LO and OO group. The result suggested that laparoscopic ovariohysterectomy is less invasive than open surgery.

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Mediastinal mass and hepatomegaly were detected by computed tomography in a 10-month-old Miniature Dachshund presenting with dyspnea. The dog was diagnosed as mediastinal T-cell lymphoma with liver invasion by cytological and clonality examination. Multidrug therapy (UW-25) was not effective for the dog. As a second-line therapy, a combination treatment of toceranib phosphate and CCNU was performed based on the expression profiling of multidrug resistance genes and angiogenic genes by qRT-PCR analysis, resulting in an improved condition. However, the dog died from dyspnea at 36 days after first examination. T-cell lymphoma was confirmed by necropsy.

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