A total of 208 cattle were affected with adiponecrosis and condemned in the northern part of Hyogo Prefecture during a 7-year period beginning with 1968. The disease became prevalent suddenly in 1973-4974, when it was the cause of condemnation for about 25% of all the dead and condemned cattle. A peak of prevalence was seen at 7-8 years, as well as at 12 years, of age. Adiponecrosis showed rapid progress and intractable. The interval between the initial examination and the condemnation was 37.8 days on the average. Inappetence and constipation always occurred and were followed by hemorrhagic diarrhea, which led to emaciation. Lack of locomotion and excessive feeding with concentrates were presumed to have induced adiponecrosis.
In apparently healthy dogs, the anterior reaflet of the mitral valve presented characteristic echocardiogram showing figure of M (type M). The posterior leaflet exhibited an echocardiogram of relatively small amplitude moving symmetrically against the anterior reaflet (type W). The echocardiogram of the aortic valve was shown between those of the anterior and posterior walls of the aorta moving synchronously with the cardiac cycle. It showed two parts to form a long rectangle by echocardiogram of right and non-coronary leaflets in the systole and presented as a single line in the diastole. The echocardiogram of the walls of the atrium and ventricle showed regular changes synchronous with the cardiac cycle coming close each other during systole and moving apart during diastole. It was, however, difficult to detect the echocardiogram of the tricuspid or pulmonary valve in the healthy dogs. The measured values of ventricular and atrial walls, of aortic walls and of interventricular septum determined by the echocardiogram were very close to those actually measured at autopsy. From these results it was concluded that the echocardiography was useful as the non-invasive test of the dynamic state and pathological changes of the heart.
In the early period of 1975, an acute fatal disease was prevalent among caged budgerigars throughout Japan. Clinical, pathologic and virologic studies were carried out on affected birds collected in Tokyo and Saitama Prefectures. The disease was characterized by inappetence, diarrhea, ruffling feathers, droopiness and a high fatality of 90-100%. No gross lesions were observed in birds that died of the illness. His. tologic examination revealed multiple focal necroses along with the formation of multinucleated giant cells in the liver and spleen. A viral agent was isolated by inoculation of chicken kidney cell cultures with the pooled extract of liver and spleen collect from affected birds, and designated as strain TI. By inoculating the isolated virus into healthy budgerigars, clinical symptoms and pathologic lesions similar to those in field cases were induced and the virus was recovered from the liver in the inoculated birds. On the basis of its physicochemical properties, the isolate was identified as a member of the paramyxovirus group. The virus was neutralized with antiserum against the Kunitachi strain of paramyxovirus that had been isolated from a budgerigar by Nakayama et al., but not with antisera against other avian paramyxoviruses, including Newcastle disease, Yucaipa, and Bangor viruses.