An experiment was carried out for 2 years to study the effects of synthesized adrenocortical hormone, calcium preparation, antibiotic, and sulfa drug upon the control of ketosis. A total of 539 dairy cows were treated with these agents for postpartum weakness, retained placenta, postpartum paralysis, puerperal fever, dystocia, and milk fever, which were accompanied by mastitis in some animals. 1. No ketosis occurred to 30 cows administered with 100mg of predonisolone 2. Ketosis was induced in 11 of 509 cows administered with 100mg of predonisolone and 250 ml of “newgrone” (25g of calcium borogluconate and 5 mg of pilocarpine hydrochloride per 100 ml). Almost all the 11 cows had shown high milk yields. 3. The frequency of occurrence of ketosis after the experimental treatment was about one-tenth of that before this treatment.
A technique for pneumoperitoneum in the dog was examined. The air insufflation of 50 ml per kg of body weight in the abdominal cavity was fit for pneumoperitoneum in the dog. A dog was placed, in the head-up or head-down position, on a table that tilted at an angle of 45 degrees. This technique was applied to 18 clinical cases. Air insufflated into the abdominal caviy was absorbed at the rate of 30 or 50 ml per day. Pneumoperitoneum in this experiment had no side effects on the clinical findings. It was suggested that pneumoperitoneum might be a useful method for examination of the abdominal structures in the dog.
A joint disease of unknown etiology broke out among goats on a farm in the Shikoku region. Its main symptoms were swelling and pain of joints of the four limbs and lameness. It was diagnosed as chronic polyarthritis on the basis of histopathological findings. 1. There were no specific findings on the components of blood. 2. Anaerobic Corynebacterium organisms, streptococci, and staphylococci were isolated from lesions of the affected joints, liver, spleen, and kidney. 3. Animals involved in clinical disease were fewer in a group administered with an antibiotic than in an untreated control group in an experiment on prevention of the disease in question. Tetracycline and erythromycin exhibited a slight therapeutical effect against this disease.
(1) DC-45, an ethyl substitute in 2-position of the pyrimidine ring of dimethialium, administered continually at a level of 16 ppm, the lowest concentration tested, had an excellent prophylactic effect against Eimeria tenella infection in chickens. Feeding of DC-45 at 31 ppm was practically effective against E. necatrix, and at 125 ppm against E. brunetti or E. acervulina, judging from the severity of intestinal lesions, weight gains, and counts of oocysts passed. (2) Ten ppm of thiamine in feed produced no significant reduction in anticoccidial activity of DC-45 provided at a level not less than 31 ppm. When DC-45 was given at a level of 16 ppm, mild hemorrhage and cecal lesions were observed, but oocysts passed increased in number. (3) There was a marked decrease in oocyst production of E. tenella in chickens fed a thiamine deficient diet. In chickens infected with E. brunetti and E. acervulina and fed a thiamine-deficient diet, oocyst output was reduced to a moderate and a small extent, resperc tively.