Forty-two dogs were administered with 5.5mg/kg of diethylcalbamazine (DEC) daily over a period from June to December every year for 13 years at most, or for 7.5 years on the average. Annual examination-revealed that all of them were negative for microfilariae in the blood and in good health. There was no significant difference in any component of serum reflecting the hepatic or renal function between the values determined in the period of administration and those in the other period of the year. In 7 dogs serum enzymatic activity was high, blood urea-nitrogenlevel 25 mg/dl, creatinine concentration 2.2 mg/dl, and hematocrit value 41.5%.
In August, 1976, a 6-year-old mongrel dog kept in Kawasaki, Kanagawa Prefecture, was examined. It had 31 eye worms on the conjunctivae, chiefly in the conjunctival sacs under the nictitating membranes. These worms were identified asThelazia callipaeda RAILLIETet HENRY, 1910. The present case is the first reported from the Kanto region in Japan. In it, eyedischarge, lacrimation, photophobia, conjunctivitis, or corneitis was not discernible.
Of 6, 427 cattle received at the Buzen Municipal Abattoir over a period of 3 years, 262 (4.08%) had nodular lesions in the intestinal mucosa. The incidence increased year by year. It was signiflcantly higher in Holsteins than in Japanese indigenous cattle. It was rather high in cows and older cattle. Most nodules were 1-5mm in diameter and prevalent in jejunum and ileum. Nodules exhibited tissue necrosis, infiltration of small round cells, appearance of foreign-body giant cells, and formation of granulation tissue.They contained stage IV larvae of Oesophagostomum radiatum.
A total of 116 Hysterectomy-Produced Colostrum-Deprived (HPCD) newborn piglets received immune substances orally and parenterally and survived to show a good growth rate. In their feces 3 days after birth, the count of bacteria was 1010cells/g and that of Enterobacteriaceae organisms ranged from 106to 108cells/g. In contrast, 29 control HPCD piglets which had been fed artificial milk without immune substances died within 10 days after birth. Escherichiacoliwas isolated as a practically pure culture from the brains of these dead animals, A mixture of 3 ml of gamma-globulin and 17 ml of artificial milk was given per osimmediately after extirpation. At the same time 2 ml of gamma-globulin was injected subcutaneously. From 6 hours to 21 days after birth piglets were fed artificial milk containing serum powder. At 4 weeks of age the average gain in body weight was 3.13 to 3.35kg. The overall feed conversion varied from 1.29 to 1.39.