Twenty-seven dairy cows suffering from mastitis were treated with 10 w/v per cent of sulfamonoinetoxine (proprietary name: daimeton), which was injected into one quarter of the udder repeatedly two to four times at a dose of 20 to 50 cc. As a result, 25 head (92 per cent) were cured. It was concluded that a therapeutic effect might be expected from this drug on mastitis in dairy cows.

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Dogs were anesthetized with pentobarbital sodium at a standard medicinal dose or a toxic dose by the intravenous route. They were examined for physiological functions with changes in respiration, heartbeat, electromyogram (of the musculus obliguus abdominis), electrocardiogram, and blood pressure as indicators for clinical findings. As a result, dogs administered with a toxic dose of the drug exhibited a remarkable inhibition of respiration, sinusal bradycardia, prolongation of the period of cardiac excitation, and other toxic symptoms of anesthesia. Some of them became fatal due to delay in waking from anesthesia.
Then an anti-barbiturate agent (β, β-methylethylglutarimide) was administered to cases of anestheticanesthetic toxication caused by overdosing of that drug. As a result, the clinical signs of anesthetic toxication were much improved and the time of waking from anesthesia was accelerated. The therapeutic dose of the agent depends on the depth of anesthesia. It may be effective to administer about 10mg/kg of the agent to a dog which has received 40mg/kg of pentobarbital sodium. In this case, the dog begins to show voluntary movements of the muscles around the eyelids and cutaneous muscles and the extension of the four limbs while the agent is being injected intravenously. Therefore, it is recommended that the dosing of the agent be carried out with the appearance of these clinical signs as standards.

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